Iléite récidivante au cours du lupus érythémateux disséminé

Bringer, J.; Jl, Richard; Ribstein, Jean; Barnéon, G.; C, de Seguin; Jj, Béraud; Sautot, G; Marchal, G; Mirouze, J

doi:10.1016/s0248-8663(81)80010-0

Cited by 3 publications

(6 citation statements)

References 16 publications

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“…In 19 of the 146 (13%) patients in whom this information was available, SLE was diagnosed simultaneously with the first episode of enteritis. Two patients presented enteritis before diagnosis of SLE [14,20]; one presented a necrotizing vasculitis of the ileum 1 month before diagnosis of SLE, another had lesions in the small intestine on capsule endoscopy 4 months before diagnosis of SLE. When patients were already diagnosed with SLE (n = 126), median time from SLE diagnosis to first episode of enteritis was 60 months (range: 5 months to 20 years).…”

Section: Introductionmentioning

confidence: 99%

“…One patient had cryoglobulin [31] (type not mentioned); no patient had positive ANCA reported. When analyzed (n = 9), ascites was a sterile exudate, unless perforation had occurred (1 case) [14]. …”

Section: Introductionmentioning

confidence: 99%

“…One patient had vasculitis of the polyarteritis nodosa type (medium size vessels). Microvascular thrombus formation was reported in 3 cases [14,16,47]. One of these patients had aPL antibodies (low positive anticardiolipin); none had diagnostic criteria for the aPL syndrome [49].…”

Section: Introductionmentioning

confidence: 99%

“…Four patients died after a median follow-up of 18 months, yielding a mortality rate of 2.7%. Reported causes of death included diffuse necrosis of intestinal tract (n = 1) [14], associated neurologic complications (n = 1) [11] and sepsis (n = 1) [19]. …”

Section: Introductionmentioning

confidence: 99%

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Lupus enteritis: from clinical findings to therapeutic management

Janssens

Arnaud

Galicier

et al. 2013

Orphanet J Rare Dis

138

181

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Lupus enteritis is a rare and poorly understood cause of abdominal pain in patients with systemic lupus erythematosus (SLE). In this study, we report a series of 7 new patients with this rare condition who were referred to French tertiary care centers and perform a systematic literature review of SLE cases fulfilling the revised ACR criteria, with evidence for small bowel involvement, excluding those with infectious enteritis. We describe the characteristics of 143 previously published and 7 new cases. Clinical symptoms mostly included abdominal pain (97%), vomiting (42%), diarrhea (32%) and fever (20%). Laboratory features mostly reflected lupus activity: low complement levels (88%), anemia (52%), leukocytopenia or lymphocytopenia (40%) and thrombocytopenia (21%). Median CRP level was 2.0 mg/dL (range 0–8.2 mg/dL). Proteinuria was present in 47% of cases. Imaging studies revealed bowel wall edema (95%), ascites (78%), the characteristic target sign (71%), mesenteric abnormalities (71%) and bowel dilatation (24%). Only 9 patients (6%) had histologically confirmed vasculitis. All patients received corticosteroids as a first-line therapy, with additional immunosuppressants administered either from the initial episode or only in case of relapse (recurrence rate: 25%). Seven percent developed intestinal necrosis or perforation, yielding a mortality rate of 2.7%. Altogether, lupus enteritis is a poorly known cause of abdominal pain in SLE patients, with distinct clinical and therapeutic features. The disease may evolve to intestinal necrosis and perforation if untreated. Adding with this an excellent steroid responsiveness, timely diagnosis becomes primordial for the adequate management of this rare entity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lupus enteritis: from clinical findings to therapeutic management

Janssens

Arnaud

Galicier

et al. 2013

Orphanet J Rare Dis

138

181

View full text Add to dashboard Cite

show abstract

“…In most cases, SLE is diagnosed before the first episode of enteritis,[ 7 ] while in about 10% of the cases, SLE is diagnosed simultaneously with the first episode of enteritis;[ 12 13 ] only few patients present with enteritis before the diagnosis of SLE. [ 13 14 ] In our patient, the clinical features of SLE appeared a month after the initial presentation of enteritis, when the steroid dose was tapered off and when the serological tests confirmed the diagnosis of SLE.…”

Section: Discussionmentioning

confidence: 70%

Mesenteric vasculitis as a rare initial presentation of systemic lupus erythematosus: A case report

Alshehri

Alhumaidi

Asseri

et al. 2020

Saudi J Med Med Sci

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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can also affect the gastrointestinal tract (GIT). The GIT symptoms are common in SLE patients, occurring in up to 40%–50% of the patients and may involve almost any organ along the GIT. Abdominal pain is the most common symptom, and an important cause of this is lupus mesenteric vasculitis (LMV). LMV is a very rare presentation of SLE, and in some cases, can precede the typical manifestations of SLE. Here, we report such a case where a 30-year-old Saudi woman presented clinically with a 2-week abdominal pain and diarrhea; the patient had not previously been diagnosed with SLE. Laboratory investigations and abdomen computed tomography imaging confirmed the diagnosis of LMV. Early recognition of this condition and its proper management improve the outcome of this serious rare initial presentation of SLE.

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Lithium Toxicity – A Chameleon to Gastrointestinal Vasculitis as an Initial Presenter of Systemic Lupus Erythematosus

Guru

Behera

Barik

et al. 2023

International Journal of Applied &Amp; Basic Medical Research

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Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. Gastrointestinal manifesting as nausea, vomiting, and pain abdomen are not so uncommon in SLE flare. However, gastrointestinal intestinal vasculitis as an initial presenter of SLE is very rare. This case report narrated gastrointestinal vasculitis as an initial presentation of systemic lupus erythematous, which mimicked lithium toxicity in a patient of preexisting bipolar disorder who was on long-term lithium therapy. A 26-year-old female presented with abdominal pain and persistent vomiting for 2 months. On further workup, she was antinuclear, anti-Smith, and anti-ds-DNA antibody positive. The serum lithium level was found to be normal computed tomography angiogram of the abdomen suggestive of vasculitis. A final diagnosis of SLE with gastrointestinal vasculitis as an initial presenter was made. She was treated with high-dose corticosteroid, cyclophosphamide, and other supportive care. She improved dramatically and was discharged with an oral corticosteroid, hydroxychloroquine, and ramipril.

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Iléite récidivante au cours du lupus érythémateux disséminé

Cited by 3 publications

References 16 publications

Lupus enteritis: from clinical findings to therapeutic management

Lupus enteritis: from clinical findings to therapeutic management

Mesenteric vasculitis as a rare initial presentation of systemic lupus erythematosus: A case report

Lithium Toxicity – A Chameleon to Gastrointestinal Vasculitis as an Initial Presenter of Systemic Lupus Erythematosus

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