İleri derecede immatür bebeklerde trombosit lenfosit oranları (TLO) ile ağır intraventriküler hemoraji (IVH) ilişkisi

Abstract

Aim: Intraventricular hemorrhage (IVH) is a serious complication of premature births, especially in newborns with very low birth weight. It's important to be able to predict IVH. In this study, the relationship between thrombocyte lymphocyte ratio (TLR) and intraventricular hemorrhage in premature infants born under 28 weeks was examined. Material and methods: In the last 5 years, the medical records of infants with less than 28 weeks of gestational age (n=78) born in our hospital have been retrospectively examined. Obtained parameters from the whole blood count, especially the relationship between TLR and IVH were examined. Results: White blood cell and lymphocyte counts were significantly higher in severe IVH (grade 3-4), while TLR was found to be significantly lower (16048±5265 & 11972±10915, p=0.043; 10705±4537 & 6329±8101, p=0.007; 36.9±22.7 & 56.7±37.9 p=0.012, respectively). When the white blood cell, lymphocyte count, and TLR's diagnostic performance in predicting severe IVH were evaluated by ROC curve analyses, it was observed that the strongest performance belonged to the TLR (Area under the curve, AUC for WBC: 0.644; ALS: 0.687; TLR: 0,691, respectively). TLR can estimate severe IVH with 94% sensitivity and 43% specificity at a cut-off value below 55.84. Conclusion: TLR can be used as a valuable marker for predicting IVH in extremely premature infants. Keywords: Intraventricular hemorrhage; platelet lymphocyte ratio; premature infants. ÖZ Amaç: İntraventriküler hemoraji (IVH), özellikle çok düşük doğum ağırlıklı yeni doğanlarda prematüre doğumların ciddi bir komplikasyonudur. IVH'yi tahmin edebilmek oldukça önemlidir. Bu çalışmada 28 hafta altında doğan prematüre bebeklerde doğumda bakılan trombosit lenfosit oranı (TLO) ve intraventriküler hemoraji (IVH) arasındaki ilişki incelenmek istenmiştir. Gereç ve yöntem: Son 5 yılda hastanemizde yatan 28 hafta altı prematüre bebeklerin (n=78) dosyaları geriye dönük incelendi. Doğum sonrası bakılan tam kan verilerinden elde edilen parametreler ve özellikle TLO ve IVH arsındaki ilişki incelendi. Bulgular: Beyaz küre ve lenfosit sayıları ciddi IVH'de (grade 3-4) anlamlı yüksek bulunurken, TLO anlamlı düşük bulunmuştur (sırasıyla 16048±5265 & 11972±10915,