Illness insight and neurophysiological error-processing deficits in schizophrenia

Kansal, Vinay; Patriciu, Iulia; Kiang, Michael

doi:10.1016/j.schres.2014.03.023

Cited by 14 publications

(16 citation statements)

References 32 publications

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“…Nearly all prior studies indicate decreased ERN in patients versus healthy controls (e.g., Foti et al, 2012, Horan et al, 2012, Kansal et al, 2014, Morris et al, 2008 with no patientcontrol differences on Pe (Horan et al, 2012, Mathalon et al, 2002, Morris et al, 2008. Our results are also consistent with two prior studies showing intact FN accompanied by impaired ERN in relatively small samples of individuals with schizophrenia (Horan et al, 2012, Morris et al, 2011.…”

Section: Discussionsupporting

confidence: 92%

“…Although it is called feedback negativity, this difference wave may actually reflect a reward-related positivity that is absent or suppressed following nonrewards , Proudfit, 2015. Many studies have found blunted ERN in schizophrenia compared to controls across different types of tasks (e.g., Foti et al, 2012, Horan et al, 2012, Kansal et al, 2014, Morris et al, 2006. Further, patients typically demonstrate normal CRN and Pe (Alain et al, 2002, Horan et al, 2012, Mathalon et al, 2002, Morris et al, 2008.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Patterns and reliability of EEG during error monitoring for internal versus external feedback in schizophrenia

Llerena¹,

Wynn²,

Hajcak

et al. 2016

International Journal of Psychophysiology

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Patterns and reliability of EEG during error monitoring for internal versus external feedback in schizophrenia

Llerena¹,

Wynn²,

Hajcak

et al. 2016

International Journal of Psychophysiology

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“…Other published studies continue to fail to find a link between insight and multiple facets of neurocognition in patients in varying phases of illness 47,51,133,134 .…”

Section: World Psychiatry 17:1 -February 2018mentioning

confidence: 99%

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

et al. 2018

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Poor insight in schizophrenia is prevalent across cultures and phases of illness. In this review, we examine the recent research on the relationship of insight with behavior, mood and perceived quality of life, on its complex roots, and on the effects of existing and emerging treatments. This research indicates that poor insight predicts poorer treatment adherence and therapeutic alliance, higher symptom severity and more impaired community function, while good insight predicts a higher frequency of depression and demoralization, especially when coupled with stigma and social disadvantage. This research also suggests that poor insight may arise in response to biological, experiential, neuropsychological, social-cognitive, metacognitive and socio-political factors. Studies of the effects of existing and developing treatments indicate that they may influence insight. In the context of earlier research and historical models, these findings support an integrative model of poor insight. This model suggests that insight requires the integration of information about changes in internal states, external circumstances, others' perspectives and life trajectory as well as the multifaceted consequences and causes of each of those changes. One implication is that treatments should, beyond providing education, seek to assist persons with schizophrenia to integrate the broad range of complex and potentially deeply painful experiences which are associated with mental illness into their own personally meaningful, coherent and adaptive picture.

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“…Event-related potential (ERP) studies of error processing in schizophrenia have focused on the error-related negativity (ERN), which occurs 0-100 ms following errors on speeded tasks (Falkenstein et al, 1991; Gehring et al, 1993) and reflects error-related activation of the anterior cingulate cortex (ACC) (Holroyd and Coles, 2002). Numerous studies have observed a blunted ERN in schizophrenia (Alain et al, 2002; Bates et al, 2002; Bates et al, 2004; Foti et al, 2012; Foti et al, 2013; Horan et al, 2012; Kansal et al, 2014; Kopp and Rist, 1999; Mathalon et al, 2002; Morris et al, 2006), which is related to poor executive function (Kim et al, 2006). A blunted ERN has also been observed in other psychotic disorders (Foti et al, 2012; Foti et al, 2013; Minzenberg et al, 2014), high-risk individuals (Laurens et al, 2010; Perez et al, 2012) and unaffected siblings (Simmonite et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Impaired error processing in late-phase psychosis: Four-year stability and relationships with negative symptoms

Foti

Hajcak

Mohanty

et al. 2016

Schizophrenia Research

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Error processing is impaired in psychosis, and numerous event-related potential studies have found reductions in the error-related negativity (ERN) and, more recently, the error positivity (Pe). The stability of reduced ERN/Pe in psychosis, however, is unknown. In a previous cross-sectional report, reduced ERN was associated with negative symptom severity and reduced Pe with a diagnosis of schizophrenia versus other psychosis. Here, we test the stability of impaired error processing over a four-year follow-up and relationships with subdimensions of negative symptoms. The ERN and Pe were recorded from individuals with psychotic disorders twice: 79 individuals were assessed 15 years after first hospitalization, and 69 were assessed at 19 years; 59 (26 with schizophrenia, 33 with other psychotic disorders) had data at both assessments. At 19 years the Pe was blunted in schizophrenia. The ERN and Pe exhibited temporal stability over the four years (r=.59 and .60, respectively). Reduced ERN and Pe correlated with the negative symptom subdimensions of inexpressivity and avolition, respectively, and not with psychotic or disorganized symptoms. Moreover, 15-year ERN predicted an increase in inexpressivity by year 19. No evidence was found for the reverse: negative symptoms did not predict change in ERN/Pe. Similar to non-clinical samples, the ERN and Pe show impressive four-year stability in late-phase psychosis. The ERN and Pe are promising neural measures for capturing individual differences in psychotic disorders, particularly with regard to negative symptomatology. They may prove to be useful clinically for forecasting illness course and as treatment targets.

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Illness insight and neurophysiological error-processing deficits in schizophrenia

Cited by 14 publications

References 32 publications

Patterns and reliability of EEG during error monitoring for internal versus external feedback in schizophrenia

Patterns and reliability of EEG during error monitoring for internal versus external feedback in schizophrenia

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

Impaired error processing in late-phase psychosis: Four-year stability and relationships with negative symptoms

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