Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics

Schoenebeck, Jeffrey J.; Yelon, Deborah

doi:10.1016/j.semcdb.2006.12.010

Cited by 51 publications

(23 citation statements)

References 61 publications

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“…PAH mixtures from weathered crude oil caused more complex cardiac dysfunction, suggestive of additional targets, including pacemaker currents and plasma membrane or sarcoplasmic calcium channels (14,15). Consistent with genetic analyses of cardiac form and function in zebrafish (17,18), this oil-induced cardiac dysfunction affects later morphogenetic steps, such as looping of the atrial and ventricular chambers into their normal side-by-side positioning (13,14). Although these morphological defects are lethal, these aggregate findings raise the question of whether milder, transient cardiac dysfunction caused by low doses of PAHs can have subtle impacts on cardiac form that could ultimately influence physiological performance later in life and, in turn, reduce survival.…”

supporting

confidence: 56%

Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish

Hicken

Linbo

Baldwin

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

306

214

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Exposure to high concentrations of crude oil produces a lethal syndrome of heart failure in fish embryos. Mortality is caused by cardiotoxic polycyclic aromatic hydrocarbons (PAHs), ubiquitous components of petroleum. Here, we show that transient embryonic exposure to very low concentrations of oil causes toxicity that is sublethal, delayed, and not counteracted by the protective effects of cytochrome P450 induction. Nearly a year after embryonic oil exposure, adult zebrafish showed subtle changes in heart shape and a significant reduction in swimming performance, indicative of reduced cardiac output. These delayed physiological impacts on cardiovascular performance at later life stages provide a potential mechanism linking reduced individual survival to population-level ecosystem responses of fish species to chronic, low-level oil pollution.

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supporting

confidence: 56%

Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish

Hicken

Linbo

Baldwin

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

306

214

View full text Add to dashboard Cite

show abstract

“…Such studies will necessarily involve an examination of the specific patterns of cellular differentiation and myocyte growth. Techniques such as neural crest cell ablation (e.g., Hutson and Kirby, 2007;Snider et al, 2007) and fate mapping (e.g., Schoenebeck and Yelon, 2007), which have been used in embryos of zebrafish and chickens, will greatly aid future examinations of the developing reptile heart. As a final note on heart development, congenital cardiovascular defects have been noted in a few instances in reptiles, either as a structural developmental defect (e.g., interventricular septal defect in Alligator mississippiensis; Brockman and Kennedy, 1962) or as failed closure of an adult structure (e.g., patent ductus arteriosus in the tortoise Testudo graeca; Burggren, 1974).…”

Section: Heart Chamber Formationmentioning

confidence: 99%

Development of cardiac form and function in ectothermic sauropsids

Crossley

Burggren

2009

Journal of Morphology

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Evolutionary morphologists and physiologists have long recognized the phylogenetic significance of the ectothermic sauropsids. Sauropids have been classically considered to bridge between early tetrapods, ectotherms, and the evolution of endotherms. This transition has been associated with many modifications in cardiovascular form and function, which have changed dramatically during the course of vertebrate evolution. Most cardiovascular studies have focused upon adults, leaving the development of this critical system largely unexplored. In this essay, we attempt a synthesis of sauropsid cardiovascular development based on the limited literature and indicate fertile regions for future studies. Early morphological cardiovascular development, i.e., the basic formation of the tube heart and the major pulmonary and systemic vessels, is similar across tetrapods. Subsequent cardiac chamber development, however, varies considerably between developing chelonians, squamates, crocodilians, and birds, reflected in the diversity of adult ventricular structure across these taxa. The details of how these differences in morphology develop, including the molecular regulation of cardiac and vascular growth and differentiation, are still poorly understood. In terms of the functional maturation of the cardiovascular system, reflected in physiological mechanisms for regulating heart rate and cardiac output, recent work has illustrated that changes during ontogeny in parameters such as heart rate and arterial blood pressure are somewhat species-dependent. However, there are commonalities, such as a beta-adrenergic receptor tone on the embryonic heart appearing prior to 60% of development. Differential gross morphological responses to environmental stressors (oxygen, hydration, temperature) have been investigated interspecifically, revealing that cardiac development is relatively plastic, especially, with respect to change in heart growth. Collectively, the data assembled here reflects the current limited morphological and physiological understanding of cardiovascular development in sauropsids and identifies key areas for future studies of this diverse vertebrate lineage.

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“…Zebrafish is a new vertebrate model for studying sarcomere assembly (Schoenebeck and Yelon, 2007;Huang et al, 2009;Sanger et al, 2009;Yang et al, 2014b). From a large-scale screen using N-ethyl-N-nitrosourea as a mutagen, a group of ttn mutants, named pickwick ( pik), have been identified (Xu et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Exon- and contraction-dependent functions of titin in sarcomere assembly

et al. 2016

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Titin-truncating variants (TTNtvs) are the major cause of dilated cardiomyopathy (DCM); however, allelic heterogeneity (TTNtvs in different exons) results in variable phenotypes, and remains a major hurdle for disease diagnosis and therapy. Here, we generated a panel of ttn mutants in zebrafish. Four single deletion mutants in ttn.2 or ttn.1 resulted in four phenotypes and three double ttn.2/ttn.1 mutants exhibited more severe phenotypes in somites. Protein analysis identified ttn xu071 as a near-null mutant and the other six mutants as hypomorphic alleles. Studies of ttn xu071 uncovered a function of titin in guiding the assembly of nascent myofibrils from premyofibrils. By contrast, sarcomeres were assembled in the hypomorphic ttn mutants but either became susceptible to biomechanical stresses such as contraction or degenerated during development. Further genetic studies indicated that the exon usage hypothesis, but not the toxic peptide or the Cronos hypothesis, could account for these exondependent effects. In conclusion, we modeled TTNtv allelic heterogeneity during development and paved the way for future studies to decipher allelic heterogeneity in adult DCM.

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Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics

Cited by 51 publications

References 61 publications

Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish

Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish

Development of cardiac form and function in ectothermic sauropsids

Exon- and contraction-dependent functions of titin in sarcomere assembly

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