Illustration of the Long‐Term Efficacy of Deep Brain Stimulation of the Thalamic Ventral Intermediate Nucleus in a Patient with Holmes Tremor Secondary to Stroke

Önder, Halil; Koçer, Bilge; Turan, Aynur; Çomoğlu, Selçuk

doi:10.1002/mdc3.13741

Cited by 1 publication

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“…Our patient had MRI changes involving the cerebellar dentate nucleus that may explain in part the movement disorder manifestations and in particular his mixed tremor symptoms. Although the precise mechanisms by which VIM-DBS influences tremor remain unknown, advances in technology and focus on neuronal synchrony as well as diffusion tractography have further emphasized the role of the cerebellothalamocortical pathway in tremor contribution (15)(16)(17). The association between corticalsubcortical pathways impacted by VIM-DBS stimulation in relation to CTX pathophysiology remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Cerebrotendinous xanthomatosis tremor successfully controlled post-ventral intermediate nucleus-deep brain stimulation: a case report

Rich,

Karakoleva,

McInerney

et al. 2023

Front. Neurol.

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Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder caused by a deficiency of the sterol 27-hydroxylase enzyme. This deficiency results in excess production and accumulation of cholestanol, which can lead to many clinical findings within the first three decades of life, including progressive neurological dysfunction. This is a treatable condition with improvements in neurological and non-neurological symptoms upon the early initiation of replacement therapy. This case report details a 42 years-old left-handed male in whom deep brain stimulation (DBS) intervention was pursued due to a limiting tremor related to delayed diagnosis and treatment of CTX at 22 years old. The application of DBS in treating tremors in a CTX patient has not previously been reported. For our patient, application of DBS led to meaningful and longstanding tremor control benefits that have required minimal changes to stimulation parameters post-DBS. These improvements to tremor were achieved without negative impact to his other CTX related comorbidities.

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Section: Discussionmentioning

confidence: 99%