Ilya Fadeyevich Tsion, Alias Elias Cyon, Alias Élie de Cyon

Zimmer, Heinz‐Gerd

doi:10.1002/clc.4960271013

Cited by 9 publications

(4 citation statements)

References 3 publications

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“…Born Ilya Fadeyevich Tsion in 1842 in a small Jewish community in Lithuania, Cyon pursued his medical education at the Warsaw Academy, followed by the University of Kyiv in Ukraine, and later completed his doctorate at the University of Berlin in Germany [ 11 ]. His academic journey took him to the St. Petersburg Medical and Surgical Academy, where he obtained another doctorate in 1865.…”

Section: Historical Backgroundmentioning

confidence: 99%

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History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology

Leivaditis,

Mulita,

Dahm

et al. 2024

Arch Med Sci Atheroscler Dis

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The isolated heart perfusion model, a fundamental tool in cardiovascular research, has evolved significantly since its inception in the late 19th century. This review traces the development of the isolated heart model, from its early adaptations by pioneers such as Langendorff and Starling to modern advancements by researchers like Morgan and Neely. We discuss the various applications of the model in pharmacological testing, disease modeling, and educational settings, emphasizing its crucial role in understanding cardiac function and disease mechanisms. Recent technological enhancements, including high-resolution imaging, integration with bioengineering, and advanced genomic and proteomic analyses, have significantly broadened the capabilities of these models. Looking forward, we explore potential future developments such as the integration of precision medicine, stem cell research, and artificial intelligence, which promise to revolutionize the use of isolated heart perfusion models. This review highlights the model’s crucial role in bridging experimental research and clinical applications.

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Section: Historical Backgroundmentioning

confidence: 99%

“…Cyon’s contributions, although initially focused on basic physiological responses to environmental changes, laid foundational insights into cardiac dynamics that have influenced decades of subsequent research in heart physiology [ 11 ].…”

Section: Historical Backgroundmentioning

confidence: 99%

History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology

Leivaditis,

Mulita,

Dahm

et al. 2024

Arch Med Sci Atheroscler Dis

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“…History of ex-vivo organ preservation (13,14) One hundred and fifty years ago, the idea to "restart" a "dead or dying heart" was utopia. The first isolated perfused heart was created by Elias Cyon, an assistant of Carl Ludwig in Leipzig at the time, in 1866.…”

Section: Cold Ischemic Storagementioning

confidence: 99%

Current approaches in retrieval and heart preservation

Vela¹,

Sáez²,

Simon³

2018

ASVIDE

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Fifty years after the first successful heart transplantation, despite multiple advances in the treatment of advanced acute and chronic heart failure, there is still no equivalent to heart transplantation as a long-term treatment for end-stage heart failure. Transplantation is, however, limited by the scarcity and quality of heart allografts. Donors are nowadays significantly older, particularly in European countries, and traumatic head injury as the cause of death has been replaced by intracerebral hemorrhage or hypoxic brain damage in the majority of cases. In addition, many donors have undergone extensive resuscitation efforts. Recipient characteristics have progressively changed too within the last couple of decades; recipients are older, often with comorbidities and nearly half of them are bridged to transplant with a wide variety of mechanical circulatory support devices. These developments have resulted in heart transplant surgery becoming significantly more challenging with longer more complex surgery and increased ischemia times for organs that were previously considered to be borderline or non-transplantable in many cases. To address this, several options have been explored within the last years and as a result, novel strategies have been developed and tested in order to optimize graft preservation and potentially increase the donor pool. The two notable developments are the ability to procure hearts from donors after circulatory death and the advent of ex-vivo perfusion of hearts. This technology has made the transplantation of extended criteria organs, including those from circulatory determined death (DCD) donors possible, and allow for out of body time of more than 12 hours in heart transplantation. In this review, we set out the basis of the current practices in organ procurement, and the opportunities for the future as demands for organ transplantation continue to increase.

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“…Elie de Cyon was a vocal critic, 14,15 but Engelmann received support from other physiologists such as Oscar Langendorff (1853Langendorff ( -1908. 16 Fig.…”

Section: Myogenic Automaticity Of the Heartmentioning

confidence: 99%

Theodor Wilhelm Engelmann

Zimmer

2006

Clinical Cardiology

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Physiological ResearchEngelmann's research career began when he was 15 years old and a student at the Thomas School in Leipzig. He studied infusoria (ciliated protozoa), an interest that led to his study of bacteria at Utrecht. Using a microspectrophotometer, Engelmann identified the phenomena of chemotaxis and phototaxis, having observed that certain bacteria were attracted by higher oxygen concentrations. 2,5 Extending his interest in the electrophysiology of striated muscle to cardiac muscle, he introduced the terms "chronotropic" for heart rate, "inotropic" for contractility of the heart, and "dromotropic" for conduction velocity. 6 In an extensive series of experiments, he studied the effect of electrically induced extrasystoles on the cardiac rhythm in experimental animals. These experiments led to his contributions to the phenomena of the refractory period and the compensatory pause. 7 He devised the ladder diagram (laddergram) as a way to depict the successive contractions of the sinus, atrium, and ventricle and to analyze arrhythmias. 8 Myogenic Automaticity of the HeartOne of Engelmann's most significant contributions to cardiac physiology was his support for the hypothesis of the myogenic theory of the heartbeat. Drawing an analogy to the physiology of smooth muscle in the intestinal tract, the ureter, and the gallbladder, he postulated that the heart's automaticity was of myogenic origin. At the time, the prevailing theory was that the rhythmic nature of the heartbeat was neurogenic in origin, 9 but he disputed the notion that the excitation of the heart originates from the ganglia.

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Ilya Fadeyevich Tsion, Alias Elias Cyon, Alias Élie de Cyon

Cited by 9 publications

References 3 publications

History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology

History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology

Current approaches in retrieval and heart preservation

Theodor Wilhelm Engelmann

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