2017
DOI: 10.1007/s10549-017-4239-z
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Image analysis of immune cell patterns in the human mammary gland during the menstrual cycle refines lymphocytic lobulitis

Abstract: Spatial patterns of different immune cell subtypes determine the range of normal, as opposed to inflammatory conditions of the breast tissue microenvironment. Advanced image analysis enables quantification of hormonal effects, refines lymphocytic lobulitis, and shows potential for comprehensive biopsy evaluation in oncoimmunology.

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Cited by 3 publications
(1 citation statement)
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“…Cancerous human breast tissues obtained from anonymized surplus archival material processed in the context of previous retrospective studies, 12 , 13 were extracted and embedded in paraffin blocks (the use of anonymized surplus archival materials for research purposes is covered by the institutional review board (ethics committee of Hannover Medical School), approval number 2063–2013). Then, they were cut into 3 μm slices and placed on a glass slide.…”
Section: Methodsmentioning
confidence: 99%
“…Cancerous human breast tissues obtained from anonymized surplus archival material processed in the context of previous retrospective studies, 12 , 13 were extracted and embedded in paraffin blocks (the use of anonymized surplus archival materials for research purposes is covered by the institutional review board (ethics committee of Hannover Medical School), approval number 2063–2013). Then, they were cut into 3 μm slices and placed on a glass slide.…”
Section: Methodsmentioning
confidence: 99%