“…A diagnosis made by a pathologist is often based on the subjective estimation and comparison of parameters such as the size of nuclei, nucleoli, and chromatin clumps, roughness of chromatin appearance, smoothness and roundness of nuclear shapes, etc. Numerous studies have aimed at developing quantitative image analysis procedures that quantitatively evaluate and compare those parameters for the resolution of diagnoses of malignancy (Bloyet et al, 1999;Deligdisch et al, 1999;Landini and Rippin, 1996;Marchevsky and Erler, 1994). A diagnosis is assigned on the basis of these features in accordance with a prescribed classificatory approach determined and validated on the basis of representative sets of cases (Deligdisch et al, 1993(Deligdisch et al, , 1995(Deligdisch et al, , 2003Dinstein et al, 2002;Wu et al, 1998aWu et al, ,b, 2004a.…”