Image-based computational hemodynamics analysis of systolic obstruction in hypertrophic cardiomyopathy

Fumagalli, Ivan; Vitullo, P; Scrofani, Roberto; Vergara, Christian

doi:10.1101/2021.06.02.21258207

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…1. Such models have been recently exploited for a variety of standalone or coupled simulations both under physiological and pathological conditions (see, e.g., [4,5,[10][11][12][13][14][15][16][17]).…”

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confidence: 99%

lifex-fiber: an open tool for myofibers generation in cardiac computational models

et al. 2023

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Background Modeling the whole cardiac function involves the solution of several complex multi-physics and multi-scale models that are highly computationally demanding, which call for simpler yet accurate, high-performance computational tools. Despite the efforts made by several research groups, no software for whole-heart fully-coupled cardiac simulations in the scientific community has reached full maturity yet. Results In this work we present $$\texttt {life}^{\texttt {x}}$$ life x -fiber, an innovative tool for the generation of myocardial fibers based on Laplace-Dirichlet Rule-Based Methods, which are the essential building blocks for modeling the electrophysiological, mechanical and electromechanical cardiac function, from single-chamber to whole-heart simulations. $$\texttt {life}^{\texttt {x}}$$ life x -fiber is the first publicly released module for cardiac simulations based on $$\texttt {life}^{\texttt {x}}$$ life x , an open-source, high-performance Finite Element solver for multi-physics, multi-scale and multi-domain problems developed in the framework of the iHEART project, which aims at making in silico experiments easily reproducible and accessible to a wide community of users, including those with a background in medicine or bio-engineering. Conclusions The tool presented in this document is intended to provide the scientific community with a computational tool that incorporates general state of the art models and solvers for simulating the cardiac function within a high-performance framework that exposes a user- and developer-friendly interface. This report comes with an extensive technical and mathematical documentation to welcome new users to the core structure of $$\texttt {life}^{\texttt {x}}$$ life x -fiber and to provide them with a possible approach to include the generated cardiac fibers into more sophisticated computational pipelines. In the near future, more modules will be successively published either as pre-compiled binaries for systems or as open source software.

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lifex-fiber: an open tool for myofibers generation in cardiac computational models

et al. 2023

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“…The initial development of life x has been oriented towards a heart module incorporating several state-of-the-art core models for the simulation of cardiac electrophysiology, mechanics, electromechanics, blood fluid dynamics and myocardial perfusion. Such models have been recently exploited for a variety of standalone or coupled simulations both under physiological and pathological conditions (see, e.g., [5,6,7,8,9,10,11,12,13,14]).…”

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life$^x$ - heart module: a high-performance simulator for the cardiac function. Package 1: Fiber generation

Africa¹,

Piersanti²,

Fedele³

et al. 2022

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Modeling the whole cardiac function involves several complex multiphysics and multi-scale phenomena that are highly computationally demanding, which makes calling for simpler yet accurate, high-performance computational tools still a paramount challenge to be addressed. Despite all the efforts made by several research groups worldwide, no software has progressed as a standard reference tool for whole-heart fully-coupled cardiac simulations in the scientific community yet.In this work we present the first publicly released package of the heart module of life x , a high-performance solver for multi-physics and multi-scale problems, aimed at cardiac applications.The goal of life x is twofold. On the one side, it aims at making in silico experiments easily reproducible and accessible to the wider public, targeting also users with a background in medicine or bioengineering, thanks to an extensive documentation and user guide. On the other hand, being conceived as an academic research library, life x can be exploited by scientific computing experts to explore new modeling and numerical methodologies within a robust development framework.life x has been developed with a modular structure and will be released bundled in different modules/packages. This initial release includes a generator for myocardial fibers based on Laplace-Dirichlet-Rule-Based-Methods (LDRBMs). This report comes with an extensive Official website: https://lifex.gitlab.io/ Download link:

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Image-based computational hemodynamics analysis of systolic obstruction in hypertrophic cardiomyopathy

Cited by 2 publications

References 21 publications

lifex-fiber: an open tool for myofibers generation in cardiac computational models

lifex-fiber: an open tool for myofibers generation in cardiac computational models

life$^x$ - heart module: a high-performance simulator for the cardiac function. Package 1: Fiber generation

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