2023
DOI: 10.1101/2023.12.01.569682
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Image-based force inference by biomechanical simulation

Michiel Vanslambrouck,
Wim Thiels,
Jef Vangheel
et al.

Abstract: During morphogenesis, cells precisely generate forces that drive cell shape changes and cellular motion. These forces predominantly arise from contractility of the actomyosin cortex, allowing for cortical tension, protrusion formation, and cell division. Image-based force inference can derive such forces from microscopy images, without complicated and time-consuming experimental set-ups. However, current methods are limited by not accounting for physical confinement and local force generation. Here we propose … Show more

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“… Cell shape has been demonstrated to be an output of intracellular and intercellular mechanics [ 69 ]. Thus, with a focus on deciphering the underlying mechanical activities and interactions from cell shapes, the quantitative approaches and data provided in this paper can be utilized in future studies [ 70 , 71 , 72 , 73 , 74 , 75 ]. For instance, the stereotypical dumbbell shape before cell division could be utilized for analyzing the curvature and tension of the cell membrane [ 76 , 77 ].…”
Section: Discussionmentioning
confidence: 99%
“… Cell shape has been demonstrated to be an output of intracellular and intercellular mechanics [ 69 ]. Thus, with a focus on deciphering the underlying mechanical activities and interactions from cell shapes, the quantitative approaches and data provided in this paper can be utilized in future studies [ 70 , 71 , 72 , 73 , 74 , 75 ]. For instance, the stereotypical dumbbell shape before cell division could be utilized for analyzing the curvature and tension of the cell membrane [ 76 , 77 ].…”
Section: Discussionmentioning
confidence: 99%