“…One of the first ideas in this regard was to digitize the anatomy of the capitellum and trochlea by means of a contact-based stylus, followed by the use of least-square fitting method to determine the corresponding geometric centers [16,10]. However, since this approach is only possible in context of in vitro studies, its later enhancements relied on CT-acquired data [9,19,20]. One of the major advantages of the "offline" imaging-based methods is that after the incipient in vitro development and validation, they can be subsequenly extended to patients by means of conventional fiducial-based registration procedures [19].…”