<p>Skin diseases have a serious impact on human life and health. This article aims to represent the classification accuracy of skin diseases for supporting the physicians’ correct decision on patients for early treatment. In particular, 100 images in each type of five skin diseases from ISIC database are used for balanced datasets related to the classification accuracy. In addition, this paper focuses on processing images for extracting six optimal types of eleven features of skin disease image for higher classification performance and also this takes less time for training. Therefore, skin disease images are filtered and segmented for separating region of interests (ROIs) before extracting optimal features. First, the skin disease images are processed by normalizing sizes, removing noises, segmenting to separate region of interests (ROIs) showing skin disease signs. Next, a gray-level co-occurrence matrix (GLCM) method is applied for texture analysis to extract eleven features. With the optimal six features chosen, the high classification accuracy of skin diseases is about 92% evaluated using a matrix confusion. The result showed to illustrate the effectiveness of the proposed method. Furthermore, this method can be developed for other medical datasets for supporting in disease diagnosis.</p>