Image Gallery: Dermatophytic pseudomycetoma caused by <i>Microsporum canis</i>

Wang, R.; Wang, X.; Li, R.

doi:10.1111/bjd.16243

Cited by 4 publications

(4 citation statements)

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“…Our search identified 57 eligible articles, of which 92 documented human infections associated with Gordonia spp. were reported [1–5, 7–58] (see for details).…”

Section: Discussionmentioning

confidence: 99%

Gordonia sputi-associated bloodstream infection in a renal transplant patient with chronic indwelling central venous catheter: a case report and literature review

Broderick

Stefanovic

et al. 2023

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Introduction. Although rare, human infections caused by Gordonia spp. have been reported, especially within the immunocompromised population and those with long-term indwelling devices. We report a case of Gordonia spp. bacteraemia in a renal transplant patient and present a literature review on microbiological identification methods of this organism. Case Presentation. A 62-year-old female renal transplant recipient admitted to hospital with a 2-month history of dry cough and fevers occurring weekly when receiving electrolyte replacement infusions via a Groshong line. Over 2 weeks, blood cultures repeatedly isolated a Gram-positive bacillus solely in aerobic bottles, and this was initially reported as Rhodococcus spp. by the local microbiology laboratory. Chest computed tomography (CT) showed multiple ground-glass lung opacities suggestive of septic pulmonary emboli. As central line-associated bloodstream infection was suspected, empirical antibiotics were initiated and the Groshong line was removed. The Gram-positive bacillus was later confirmed by the reference laboratory as Gordonia sputi via 16S rRNA sequencing. Vancomycin and ciprofloxacin for a duration of 6 weeks were completed as targeted antimicrobial therapy. After treatment, the patient remained symptom-free with marked improvement on repeat CT chest imaging. Conclusion. This case illustrates the challenges surrounding identification of Gordonia spp. and other aerobic actinomycetes. 16S rRNA gene sequencing may be a preferred identification method, especially when initial workup of a weakly acid-fast organism fails to make an identification or shows discrepant results using traditional diagnostic modalities.

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“…Our search identified 57 eligible articles, of which 92 documented human infections associated with Gordonia spp. were reported [1–5, 7–58] (see for details).…”

Section: Discussionmentioning

confidence: 99%

Gordonia sputi-associated bloodstream infection in a renal transplant patient with chronic indwelling central venous catheter: a case report and literature review

Broderick

Stefanovic

et al. 2023

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“…Invasive dermatophytosis is divided into four major classifications: Majocchi's granuloma, deeper dermal dermatophytosis, pseudomycetoma and disseminated infection (Figure 1). 17–20 Majocchi's granuloma is the most indolent form, which can be subclassified into two types: suppurative folliculitis and nodular granulomatous infection 5 . The first type usually develops after physical trauma, which leads to disruption of hair follicles and presents as folliculitis or perifolliculitis 21,22 .…”

Section: Discussionmentioning

confidence: 99%

“…(B2) Histopathology of the lesions showing fungal hyphae in the deep dermis (Periodic Acid‐Schiff stain, ×400). (C1) Pseudomycetoma presenting as multiple confluent subcutaneous nodules on the left wrist 20 . (C2) A punch biopsy from the lesions showing hyphal aggregates embedded in homogeneous eosinophilic material (haematoxylin‐eosin stain, ×400) 20 …”

Section: Discussionmentioning

confidence: 99%

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Invasive dermatophyte infection: A systematic review

Wang

Huang

Zhang

et al. 2020

Mycoses

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Dermatophyte infections usually present as various types of superficial cutaneous mycoses; on very rare occasions, dermatophytes enter deep into the dermis and cause invasive infections. In this study, we aimed to perform a systematic review of all reported invasive dermatophytosis cases over the past 20 years. We performed systematic searches in PubMed/Medline, EMBASE and Web of Science and identified 123 papers reporting 160 individual cases of invasive dermatophytosis between 2000 and 2020. Our study included 103 (64.4%) males, and the mean age at diagnosis was 43.0 years (range: 3–87 years). The most common predisposing factor was superficial dermatophytosis (56.9%), followed by solid organ transplantation (26.9%), the use of topical immunosuppressants (15.6%), gene mutations (14.4%), diabetes (14.4%) and trauma (6.9%). Trichophyton (T.) rubrum was the most prevalent pathogen (53.1%) responsible for invasive dermatophytosis, followed by T. mentagrophytes (7.5%), Microsporum canis (6.9%), T. tonsurans (5.6%), T. interdigitale (5.0%) and T. violaceum (3.8%). Patients with CARD9 or STAT3 mutations were prone to have mixed infection of two or more dermatophytes, present with eosinophilia and high IgE, and develop disseminated infections. Overall mortality was 7.9%, and the mortality in patients with and without gene mutations was 17.4% and 5.5%, respectively. Most of the normal host patients responded well to oral antifungal agents, while gene‐deficient patients usually required lifelong treatment to stabilise their infection status. Our review indicated the importance of preventive treatment of superficial tinea in patients with immunosuppression and gene deficiencies to avoid the development of invasive dermatophytosis.

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