Image Guided Brachytherapy for Cancer of the Nasal Vestibule: Local Control and Cosmesis

Czerwiński, Michał; Leeuwen, Ruud G.H. van; Kaanders, Johannes H.A.M.; Zwijnenburg, Ellen M.; Lipman, Djoeri; Takes, Robert P.; Verhoef, C.

doi:10.1016/j.ijrobp.2018.11.018

Cited by 33 publications

(36 citation statements)

References 19 publications

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“…Our survival results appear to be in accordance to those reported in literature (Table IV). In agreement to a myriad of studies, 3,5,[21][22][23]29 we also report how tumor staging, site of origin, tumor grading, extent of surgery and surgical margins are well-known prognostic factors impacting on survival and recurrence rates (Table III). Particularly, tumor arising from septum/columella seems to be more aggressive with worse locoregional control rate in respect to other site of origin.…”

Section: Discussionsupporting

confidence: 89%

“…According to literature, loco-regional recurrences seem to occur mostly within the first 2 years from primary treatment. 3,8,22,23,29 In our opinion, this would justify an intensified follow-up during this period, with fourmonthly neck ultrasound and magnetic resonance. So far, the overall incidence of neck nodal metastases appear to be approximately 15%-20%.…”

Section: Discussionmentioning

confidence: 94%

“…Some authors argue that nonsurgical approaches (BRT) achieve good oncological results, with 5-year local control rate of 98%-95%, and better cosmetic outcomes when compared to surgical excision. 4,12,[22][23][24][25][26] In the case of primary surgical treatment, the 5-year OS rate is reported to be about 91%-92%. 8,9 Nonetheless, the scientific reports directly comparing the different treatment modalities are scarce.…”

Section: Discussionmentioning

confidence: 99%

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Squamous Cell Carcinoma of Nasal Vestibule and Pyramid: Outcomes and Reconstructive Strategies

et al. 2020

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Objectives: Squamous cell carcinoma of nasal vestibule and pyramid is rare, thus classification, treatment protocol, and indications for elective neck treatment are still controversial. Nasal reconstruction is challenging, as well, and prosthesis is still used. Study Design: Retrospective cohort study. Methods: Retrospective review of patients surgically treated from 2010 to 2018 in a single Institution. Advanced tumors were further treated with adjuvant irradiation. Reconstruction strategy included grafts, locoregional and free flaps, and was customized on layers removed. Results: Forty-five patients were enrolled. The 5-year overall survival and disease-free survival were 81.9% AE 7.45% and 61.9% AE 9.09%, respectively. Wang's classification, site of origin, extent of surgery and margins status significantly correlated with prognosis and recurrence rate. Regional recurrences occurred in patients affected by advanced tumors who did not receive any form of elective neck treatment. Conclusion: Multidisciplinary management and a proper reconstructive algorithm are recommended. Adjuvant irradiation and elective neck treatment should be advocated for advanced stage high-risk patients.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Squamous Cell Carcinoma of Nasal Vestibule and Pyramid: Outcomes and Reconstructive Strategies

et al. 2020

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“…Oncological outcomes Surgery, External Beam RadioTherapy (EBRT) and Interventional RadioTherapy (IRT, BrachyTherapy BT) are the current therapeutic options in clinical practice 3,[9][10][11][12][13][14] , as there are not clear evidences of superiority for any modality. Recent papers focusing on the comparison between surgery and IRT 4 and on IRT alone 5,15,16 showed that brachytherapy as primary treatment of the T is not inferior to surgery as for oncological results (OS over 90% in cT1 and cT2 according to Wang).…”

Section: Current Treatment Options For Nose Vestibule Sccs: Evidence Supporting Brachytherapy As the New Standard For Treatment Of The Prmentioning

confidence: 99%

Multidisciplinary approach to nose vestibule malignancies: setting new standards

Bussu

Tagliaferri

Piras

et al. 2021

Acta Otorhinolaryngol Ital

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Nose vestibule malignancies, mainly SCCs, are considered rare neoplasms. In the present paper, we review the current state of the art concerning classification and treatment, and describe current evidence supporting a paradigm shift. In the current AJCC classification nose vestibule is considered part of nasal cavity/ethmoid. In daily clinical practice, nose vestibule lesions are often misclassified as skin primaries. This leads to an underestimation of the real incidence and to a mis-management. When nose vestibule primaries are correctly classified as nose primaries, the current AJCC TNM appears inadequate for prognostic stratification and an old staging system described 4 decades ago by Wang has been demonstrated to be more reliable in the literature and is preferred in centers with the largest volume of cases treated. The principles of Wang classification should be applied and nose vestibule acknowledged as a new distinct subsite of nose and paranasal sinuses by the AJCC/ UICC. Surgery, External Beam RadioTherapy (EBRT) and Interventional RadioTherapy (IRT, BrachyTherapy BT) are the current therapeutic options for nose vestibule (NV) SCC. Increasing evidence demonstrates that IRT, with a proper multidisciplinary approach, is at least equivalent to surgery and EBRT for treatment of the primary lesions in terms of oncological outcomes, but markedly superior in terms of cosmetic and functional results, supporting HDR (high dose rate) IRT as the new standard for the treatment of the primary lesion in these malignancies. To optimize the advantages of IRT as primary therapeutic modality we set up a new approach to the implantation phase of IRT exploiting the anatomic planes of esthetic and functional nose surgery and the potential of intensity modulated and image guided brachytherapy to avoid septal and alar perforation (anatomic implantation).

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“…Między innymi dlatego tak duże wrażenie robi liczebność grupy w tej pracy retrospektywnej -aż 102 chorych leczonych było przez dr. Czerwinskiego i wsp. za pomocą samodzielnej śródtkankowej (n=77) i kontaktowej (n=25) brachyterapii HDR w latach 1992-2015 [8]. Zaawansowanie miejscowe nowotworów wg kalsyfikacji Wang'a ograniczone było do stopni T1 i T2 odpowiednio u 82 i 20 pacjentów, natomiast 3 chorych miało również przerzuty do węzłów chłonnych szyi w momencie rozpoznania i otrzymali oni leczenie chirurgiczne z uzupełniającą teleradioterapią.…”

Section: Rak Przedsionka Nosaunclassified

Ocena efektów kosmetycznych radioterapii interwencyjnej (brachyterapii) w świetle doniesień konferencji ESTRO37.

Chyrek

2020

LOS

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Na przełomie kwietnia i maja 2018 roku w Barcelonie, w Hiszpanii odbyła się 37 konferencja naukowa Europejskiego Towarzystwa Radioterapii Onkologicznej (ESTRO). W jej trakcie po raz kolejny prezentowany był panel grupy GEC-ESTRO zajmującej się radioterapią interwencyjną (brachyterapią), która polega na bezpośrednim wprowadzeniu izotopu promieniotwórczego w guza lub jego lożę. Artykuł ten ma na celu prezentację doniesień dotyczących efektów kosmetycznych brachyterapii stosowanej u Pacjentów nie tylko po to by wyleczyć nowotwór, ale również by pozwolić na zaoszczędzenie narządów, w których jest on zlokalizowany.

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Image Guided Brachytherapy for Cancer of the Nasal Vestibule: Local Control and Cosmesis

Cited by 33 publications

References 19 publications

Squamous Cell Carcinoma of Nasal Vestibule and Pyramid: Outcomes and Reconstructive Strategies

Squamous Cell Carcinoma of Nasal Vestibule and Pyramid: Outcomes and Reconstructive Strategies

Multidisciplinary approach to nose vestibule malignancies: setting new standards

Ocena efektów kosmetycznych radioterapii interwencyjnej (brachyterapii) w świetle doniesień konferencji ESTRO37.

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