Image-guided drug delivery in nanosystem-based cancer therapies

Camptothecin-based prodrug nanomedicines for cancer therapy

“…86 Particularly, the development of tumor-specific activated fluorescent probes meets the need for real-time feedback during tumor treatment. 87 In Zhang's design, the engineering of a GSH-labile near-infrared (NIR) CPT prodrug nanoplatform for fluorescence imaging in tumor therapy was developed. 88 In this study, the NIR prodrug POEGMA- b -P(CPT-CyOH) ( PCC ) was firstly synthesized, which could self-assemble in water to produce the PCC micelle-based nanoprodrugs for in vivo delivery of the NIR probe CyOH and therapeutic drug CPT (Fig.…”

Construction of glutathione-responsive paclitaxel prodrug nanoparticles for image-guided targeted delivery and breast cancer therapy

“…However, noncovalent encapsulation has been criticized for its poor stability, low drug delivery efficiency, and premature leakage of drug or uorescent dye in the systemic circulation. 12,13 Consequently, these issues urge us to develop a particular visualized prodrug to improve metabolic stability and real-time monitoring of drug location.…”

Delivery of miR‐3529‐3p using MnO2‐SiO2‐APTES nanoparticles combined with phototherapy suppresses lung adenocarcinoma progression by targeting HIGD1A

“…To confront these challenges, researchers from different disciplines, including therapeutics, chemistry, materials science, and pharmacology, have collaborated closely to apply nanosystems to cancer therapies 7–10 . Nanosystems within the dimensions of 1 to 100 nm have been proposed for their minimal invasiveness, high effectiveness, and efficient drug delivery 11–13 . Several variants of nano‐drug delivery systems have been successfully studied for therapeutic applications, such as liposomes, dendrimers, polymeric nanoparticles, nanoemulsions, carbon nanotubes, gold nanoparticles, magnetic nanoparticles, solid lipid nanoparticles, hydrogels, and micelles 2 .…”

“… 7 , 8 , 9 , 10 Nanosystems within the dimensions of 1 to 100 nm have been proposed for their minimal invasiveness, high effectiveness, and efficient drug delivery. 11 , 12 , 13 Several variants of nano‐drug delivery systems have been successfully studied for therapeutic applications, such as liposomes, dendrimers, polymeric nanoparticles, nanoemulsions, carbon nanotubes, gold nanoparticles, magnetic nanoparticles, solid lipid nanoparticles, hydrogels, and micelles. 2 More importantly, some nanosystems could be developed to include extra therapy functions, like photothermal therapy (PTT).…”