Image-Guided High-Intensity Focused Ultrasound for Conduction Block of Peripheral Nerves

Foley, Jessica L.; Little, James W.; Vaezy, Shahram

doi:10.1007/s10439-006-9162-0

Cited by 67 publications

(64 citation statements)

References 33 publications

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“…Several research groups have also reported that the modulation of neural activity is feasible through the application of short bursts of ultrasound pulses (14–18), demonstrated by using a wide range of pulsing schemes having variations in duty cycle (DC), tone-burst duration (TBD), pulse-repetition frequency (PRF), sonication duration (SD), acoustic intensity (AI), and fundamental frequency (FF). On the other hand, continuous ultrasound waves have also been shown to modulate the brain neural activities (9, 19–21); however, the question remains as to which one is more effective in achieving the desired modulation.…”

Section: Introductionmentioning

confidence: 99%

Focused Ultrasound-mediated Non-invasive Brain Stimulation: Examination of Sonication Parameters

et al. 2014

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Background Transcranial focused ultrasound (FUS) has emerged as a new brain stimulation modality. The range of sonication parameters for successful brain stimulation warrants further investigation. Objective The objective of this study was to examine the range of FUS sonication parameters that minimize the acoustic intensity/energy deposition while successfully stimulating the motor brain area in Sprague-Dawley rats. Methods We transcranially administered FUS to the somatomotor area of the rat brain and measured the acoustic intensity that caused excitatory effects with respect to different pulsing parameters (tone-burst duration, pulse-repetition frequency, duty cycle, and sonication duration) at 350 and 650 kHz of fundamental frequency. Results We observed that motor responses were elicited at minimum threshold acoustic intensities (4.9–5.6 W/cm2 in spatial-peak pulse-average intensity; 2.5–2.8 W/cm2 in spatial-peak temporal-average intensity) in a limited range of sonication parameters, i.e. 1–5 ms of tone-burst duration, 50% of duty cycle, and 300 ms of sonication duration, at 350 kHz fundamental frequency. We also found that the pulsed sonication elicited motor responses at lower acoustic intensities than its equivalent continuous sonication. Conclusion Our results suggest that the pulsed application of FUS selectively stimulates specific brain areas-of-interest at an acoustic intensity that is compatible with regulatory safety limits on biological tissue, thus allowing for potential applications in neurotherapeutics.

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Section: Introductionmentioning

confidence: 99%

Focused Ultrasound-mediated Non-invasive Brain Stimulation: Examination of Sonication Parameters

et al. 2014

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“…1,13,15,16 During the 1950s, high-intensity focused ultrasound (HIFU) was used experimentally to reversibly inhibit neuronal activity through moderate heating below the threshold for tissue ablation, 14 and it was used clinically to treat patients with movement disorders and brain tumors. 17,27 Advances in noninvasive, transcranial delivery of ultrasound over the past 15 years have renewed an interest in its use for neurosurgical applications.…”

mentioning

confidence: 99%

Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

Dallapiazza¹,

Timbie

Holmberg

et al. 2018

Journal of Neurosurgery

197

175

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OBJECTIVE Ultrasound can be precisely focused through the intact human skull to target deep regions of the brain for stereotactic ablations. Acoustic energy at much lower intensities is capable of both exciting and inhibiting neural tissues without causing tissue heating or damage. The objective of this study was to demonstrate the effects of low-intensity focused ultrasound (LIFU) for neuromodulation and selective mapping in the thalamus of a large-brain animal. METHODS Ten Yorkshire swine ( Sus scrofa domesticus) were used in this study. In the first neuromodulation experiment, the lemniscal sensory thalamus was stereotactically targeted with LIFU, and somatosensory evoked potentials (SSEPs) were monitored. In a second mapping experiment, the ventromedial and ventroposterolateral sensory thalamic nuclei were alternately targeted with LIFU, while both trigeminal and tibial evoked SSEPs were recorded. Temperature at the acoustic focus was assessed using MR thermography. At the end of the experiments, all tissues were assessed histologically for damage. RESULTS LIFU targeted to the ventroposterolateral thalamic nucleus suppressed SSEP amplitude to 71.6% ± 11.4% (mean ± SD) compared with baseline recordings. Second, we found a similar degree of inhibition with a high spatial resolution (∼ 2 mm) since adjacent thalamic nuclei could be selectively inhibited. The ventromedial thalamic nucleus could be inhibited without affecting the ventrolateral nucleus. During MR thermography imaging, there was no observed tissue heating during LIFU sonications and no histological evidence of tissue damage. CONCLUSIONS These results suggest that LIFU can be safely used to modulate neuronal circuits in the central nervous system and that noninvasive brain mapping with focused ultrasound may be feasible in humans.

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“…15,25,26,70,86 Other studies have demonstrated activation of neural tissue, both peripherally and in the CNS. 32,50,81 These effects have been postulated to occur as a result of mechanical stimuli (reversible) and thermal ablation (potentially irreversible).…”

Section: Neuromodulation and Epilepsymentioning

confidence: 99%

High-intensity focused ultrasound: past, present, and future in neurosurgery

Quadri¹,

Waqas

Khan

et al. 2018

Neurosurgical Focus

123

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Since Lynn and colleagues first described the use of focused ultrasound (FUS) waves for intracranial ablation in 1942, many strides have been made toward the treatment of several brain pathologies using this novel technology. In the modern era of minimal invasiveness, high-intensity focused ultrasound (HIFU) promises therapeutic utility for multiple neurosurgical applications, including treatment of tumors, stroke, epilepsy, and functional disorders. Although the use of HIFU as a potential therapeutic modality in the brain has been under study for several decades, relatively few neuroscientists, neurologists, or even neurosurgeons are familiar with it. In this extensive review, the authors intend to shed light on the current use of HIFU in different neurosurgical avenues and its mechanism of action, as well as provide an update on the outcome of various trials and advances expected from various preclinical studies in the near future. Although the initial technical challenges have been overcome and the technology has been improved, only very few clinical trials have thus far been carried out. The number of clinical trials related to neurological disorders is expected to increase in the coming years, as this novel therapeutic device appears to have a substantial expansive potential. There is great opportunity to expand the use of HIFU across various medical and surgical disciplines for the treatment of different pathologies. As this technology gains recognition, it will open the door for further research opportunities and innovation.

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Image-Guided High-Intensity Focused Ultrasound for Conduction Block of Peripheral Nerves

Cited by 67 publications

References 33 publications

Focused Ultrasound-mediated Non-invasive Brain Stimulation: Examination of Sonication Parameters

Focused Ultrasound-mediated Non-invasive Brain Stimulation: Examination of Sonication Parameters

Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

High-intensity focused ultrasound: past, present, and future in neurosurgery

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