Image-guided Interstitial Brachytherapy in the Management of Metastasized Anal Squamous Cell Carcinoma

Heinze, Constanze; Omari, Jazan; Othmer, Max; Hass, Peter; Seidensticker, Max; Damm, Robert; Ricke, Jens; Pech, Maciej; Powerski, Maciej

doi:10.21873/anticanres.12870

Cited by 4 publications

(5 citation statements)

References 21 publications

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“…In our study we report an LTC rate of 92.6% during a follow-up period of 10.2 months with no grade 3 or worse adverse events. These results are comparable to the efficacy after ablation of primary and secondary liver malignancies, demonstrating LTC rates of 95% and 88.3% after 12 months, respectively (13,15,19) or to the excellent LTC rate of 97.4% after the ablation of metastasized anal squamous cell carcinoma (14).…”

Section: Discussionsupporting

confidence: 61%

“…As stated in the literature, grade 3-4 toxicities -i.e. bleeding, requiring angiographic embolization -are reported to occur in up to 2% of the patients undergoing local ablation of liver lesions (13,14,18,32). In our study, we did not observe major complications (grade 3 or worse) associated to the procedure in the post-interventional period or during the follow-up period.…”

Section: Discussioncontrasting

confidence: 40%

“…The interventional technique has been described elsewhere in detail (14,17,18). The quantity and arrangement of the catheters used was determined by the anatomy of the target lesion.…”

Section: Methodsmentioning

confidence: 99%

“…This technique enables a delineated single-fraction irradiation of the target volume. iBT has already been shown to be an efficient and mild treatment, with a minimum of complications, in ablation of primary or secondary malignancies at various sites (13)(14)(15)(16)(17). To our knowledge, no study has assessed the feasibility of iBT in the treatment of mRCC.…”

mentioning

confidence: 99%

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Radioablation of Hepatic Metastases from Renal Cell Carcinoma With Image-guided Interstitial Brachytherapy

et al. 2019

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Background/Aim: High-dose-rate interstitial brachytherapy (iBT) has been shown to provide high tumor control rates in the treatment of primary or secondary malignancies at various sites. The objective of this study was to evaluate the efficacy and safety of image-guided iBT in patients with metastatic renal cell carcinoma (mRCC). Materials and Methods: A total of 14 patients with a cumulative number of 54 unresectable RCC liver metastases after treatment with computed tomography (CT)-or open magnetic resonance imaging (MRI)-guided iBT using an iridium-192 source (single fraction irradiation) were included in this retrospective study. Results: Local tumor control rate was 92.6% during a median follow-up of 10.2 months (range=2.4-73.6 months). Median progression-free survival after iBT was 3.4 months (range=1.0-27.8 months). Median overall survival was 51.2 months (range=10.2-81.5 months). No severe adverse events (grade 3 or more) were recorded. Conclusion: Image-guided iBT is a safe and feasible treatment in patients with mRCC.

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Section: Discussionsupporting

confidence: 61%

Section: Discussioncontrasting

confidence: 40%

“…The interventional technique has been described elsewhere in detail (14,17,18). The quantity and arrangement of the catheters used was determined by the anatomy of the target lesion.…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Radioablation of Hepatic Metastases from Renal Cell Carcinoma With Image-guided Interstitial Brachytherapy

et al. 2019

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“…IBT has already been shown to be a gentle treatment with a minimum of complications in ablation of primary or secondary malignancies at various sites, e.g. colorectal cancer or hepatocellular carcinoma [9,10,11,12]. To our knowledge, no data has been published so far evaluating the efficacy of iBT in the treatment of rLNM.…”

Section: Purposementioning

confidence: 99%

Efficacy and safety of percutaneous computed tomography-guided high-dose-rate interstitial brachytherapy in treatment of oligometastatic lymph node metastases of retroperitoneal space

Heinze

Omari

Manig

et al. 2019

jcb

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PurposeTo assess efficacy, safety, and outcome of computed tomography (CT)-guided high-dose-rate (HDR) interstitial brachytherapy in patients with oligometastatic lymph node metastases of the retroperitoneal space.Material and methods24 patients with a total of 47 retroperitoneal lymph node metastases from different primary tumors were treated with CT-guided interstitial brachytherapy using an 192Ir source (single fraction irradiation). Every three months after treatment, clinical and imaging follow-up were conducted to evaluate local control and safety.ResultsMedian follow-up was 9.6 months (range, 2.9-39.0 months). Local tumor control rate was 95.7%. The median diameter of the gross tumor volume was 2.2 cm (range, 1-8.6 cm), treated with a median D100 (minimal enclosing tumor dose) of 14.9 Gy (range, 4.5-20.6 Gy). One severe adverse event (grade three) was recorded.Cumulative median progression-free survival was 4.2 months (range, 1.4-23.7 months), and cumulative median overall survival after interstitial brachytherapy was 15.9 months (range, 3.8-39.0 months).ConclusionsCT-guided HDR interstitial brachytherapy is a safe and feasible method for local ablation of oligometastatic lymph node metastases of the retroperitoneal space, and might provide a well-tolerated additional therapeutic option in the multidisciplinary management of selected patients.

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Lung Brachytherapy: Experience from Germany

Peters

2021

Manual on Image-Guided Brachytherapy of Inner Organs

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Image-guided Interstitial Brachytherapy in the Management of Metastasized Anal Squamous Cell Carcinoma

Abstract: Image-guided IBT is a safe and particularly effective treatment in patients with mASCC and might provide a well-tolerated therapeutic option in a multidisciplinary setting.

Cited by 4 publications

References 21 publications

Radioablation of Hepatic Metastases from Renal Cell Carcinoma With Image-guided Interstitial Brachytherapy

Radioablation of Hepatic Metastases from Renal Cell Carcinoma With Image-guided Interstitial Brachytherapy

Efficacy and safety of percutaneous computed tomography-guided high-dose-rate interstitial brachytherapy in treatment of oligometastatic lymph node metastases of retroperitoneal space

Lung Brachytherapy: Experience from Germany

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