Image Guided Radiation Therapy (IGRT) Technologies for Radiation Therapy Localization and Delivery

Santos, Jennifer De Los; Popple, Richard A.; Agazaryan, Nzhde; Bayouth, John E.; Bissonnette, Jean Pierre; Bucci, M. Kara; Dieterich, Sonja; Dong, Lei; Forster, Kenneth; Indelicato, Daniel J.; Langen, K; Lehmann, Jöerg; Mayr, Nina A.; Parsai, I; Salter, William R.; Tomblyn, Michael; Yuh, William T. C.; Chetty, Indrin J.

doi:10.1016/j.ijrobp.2013.02.021

Cited by 131 publications

(60 citation statements)

References 132 publications

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“…Cone beam computed tomography (CBCT) has become a widespread tool for image guidance in radiotherapy . The device provides three or four dimensional images of patient anatomy for the purpose of the patient position verification before and∖or during the treatment depending on the disease site and fractionation scheme.…”

Section: Introductionmentioning

confidence: 99%

Optimal combination of anti‐scatter grids and software correction for CBCT imaging

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Optimal combination of anti‐scatter grids and software correction for CBCT imaging

et al. 2017

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“…Oxygen enhanced MRI has been suggested as a potential alternative approach, since it is entirely non-invasive and can be readily added to routine clinical MRI, which is increasingly applied to radiation planning and execution [29]. The tissue water proton apparent transverse relaxation rate (R 2 *) is strongly influenced by the concentration of deoxyhemoglobin, which is paramagnetic [2, 28].…”

Section: Introductionmentioning

confidence: 99%

Developing oxygen-enhanced magnetic resonance imaging as a prognostic biomarker of radiation response

White

Zhang

et al. 2016

Cancer Letters

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Oxygen-Enhanced Magnetic Resonance Imaging (OE-MRI) techniques were evaluated as potential non-invasive predictive biomarkers of radiation response. Semi quantitative blood-oxygen level dependent (BOLD) and tissue oxygen level dependent (TOLD) contrast, and quantitative responses of relaxation rates (ΔR1 and ΔR2*) to an oxygen breathing challenge during hypofractionated radiotherapy were applied. OE-MRI was performed on subcutaneous Dunning R3327-AT1 rat prostate tumors (n = 25) at 4.7 T prior to each irradiation (2Fx15 Gy) to the gross tumor volume. Response to radiation, while inhaling air or oxygen, was assessed by tumor growth delay measured up to four times the initial irradiated tumor volume (VQT). Radiation-induced hypoxia changes were confirmed using a double hypoxia marker assay. Inhaling oxygen during hypofractionated radiotherapy significantly improved radiation response. A correlation was observed between the difference in the 2nd and 1st ΔR1 (ΔΔR1) and VQT for air breathing rats. The TOLD response before the 2nd fraction showed a moderate correlation with VQT for oxygen breathing rats. The correlations indicate useful prognostic factors to predict tumor response to hypofractionation and could readily be applied for patient stratification and personalized radiotherapy treatment planning.

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“…There are multiple types of technology that can be used for IGRT . A list of IGRT technologies that might be used include:…”

Section: The Promise Of Igrtmentioning

confidence: 99%

Faculty of Radiation Oncology Position Paper on the use of Image–Guided Radiation Therapy

et al. 2016

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The development of technology such as intensity-modulated radiotherapy (IMRT), volumetric arc therapy (VMAT) and stereotactic ablative body radiotherapy (SABR) has resulted in highly conformal radiotherapy treatments. While such technology has allowed for improved dose delivery, it has also meant that improved accuracy in the treatment room is required. Image-guided radiotherapy (IGRT), the use of imaging prior to or during treatment delivery, has been shown to improve the accuracy of treatment delivery and in some circumstances, clinical outcomes. Allied with the adoption of highly conformal treatments, there is a need for stringent quality assurance processes in a multidisciplinary environment. In 2015, the Royal Australian and New Zealand College of Radiologist (RANZCR) updated its position paper on IGRT. The draft document was distributed through the membership of the Faculty of Radiation Oncology (FRO) for review and the final version was endorsed by the board of FRO. This article describes issues that radiotherapy departments throughout Australia and New Zealand should consider. It outlines the role of IGRT and reviews current clinical evidence supporting the benefit of IGRT in genitourinary, head and neck, and lung cancers. It also highlights important international publications which provide guidance on implementation and quality assurances for IGRT. A set of key recommendations are provided to guide safe and effective IGRT implementation and practice in the Australian and New Zealander context.

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Image Guided Radiation Therapy (IGRT) Technologies for Radiation Therapy Localization and Delivery

Cited by 131 publications

References 132 publications

Optimal combination of anti‐scatter grids and software correction for CBCT imaging

Optimal combination of anti‐scatter grids and software correction for CBCT imaging

Developing oxygen-enhanced magnetic resonance imaging as a prognostic biomarker of radiation response

Faculty of Radiation Oncology Position Paper on the use of Image–Guided Radiation Therapy

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