Image-guided surgery in oral cancer: toward improved margin control

Abstract

Purpose of reviewThe aim of this review is to discuss recent studies on the assessment of tumor extension and resection margins by different intraoperative techniques allowing for image-guided surgery of oral cancer. Recent findingsThere are different in-vivo and ex-vivo intraoperative techniques to improve margin control of which intraoperative ultrasound and targeted fluorescence-guided resections have high potential clinical value and are closest to clinical implementation.

Transcranial direct current stimulation in the treatment of anxiety and depression in patients with oral cancer during perioperative period

“…[7] Surgical resection is the first choice and gold standard treatment for curative purposes in patients with OC. [8][9][10] However, most patients who undergo surgery during the perioperative period (PPP) often experience psychological disorders, such as anxiety and depression. [11][12][13][14] Transcranial direct current stimulation (tDCS) is a safe, noninvasive, and painless treatment technique.…”

Surgical Extent for Oral Cancer: Emphasis on a Cut-Off Value for the Resection Margin Status: A Narrative Literature Review

“…The limitations of deep resection frequently result in a suboptimal margin status. Some researchers have attempted real-time imaging, such as ultrasonography during surgery [ 18 , 19 ] or in vivo imaging [ 20 , 21 , 22 , 23 ]; however, a common and broad application of real-time imaging to a practice requires further development and clinical research. In short, a surgical strategy for complete tumor removal can be accomplished under the current surgical approach only with a tumor resection that includes safety margins from the boundaries of presumed gross tumors.…”

Intraoperative assessment of resection margins by Raman spectroscopy to guide oral cancer surgery

“…A range of techniques, among which fluorescence imaging, ultrasound-guided resection, and magnetic resonance imaging of tongue cancer specimens is currently being explored for application in objective IOARM. [7][8][9][10][11][12] Raman spectroscopy is a non-destructive, label-free, optical technique, that provides information about the overall molecular composition of tissues. The development of medical applications of this technique is rapidly gaining momentum.…”

“…A range of techniques, among which fluorescence imaging, ultrasound-guided resection, and magnetic resonance imaging of tongue cancer specimens is currently being explored for application in objective IOARM. 7–12…”