Infective endocarditis (IE) is defined as infection of the endocardial surface of the heart which may involve heart valve, mural endocardium or septal defect. It’s a disease with high morbidity and mortality without prompt treatment with antibiotics. Janeway lesions, Osler’s node and splinter hemorrhages are the classical signs of infective endocarditis described previously. However, these signs are not commonly seen nowadays. In this present paper, we would like to illustrate a case of IE with typical Janeway lesions.