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Abstract (Maximum 200 Words) (abstract should contain no oroorietarv or confidential information)The broad objective of the proposed project is to investigate, develop, and evaluate the application of three-dimensional (3D) ultrasonic diffraction tomography (UDT) for detection of breast cancer. UDT can be viewed as a generalization of X-ray tomography where X-rays have been replaced with an acoustical wavefield. It can determine refractive index distributions within the breast that are of interest clinically and can be an excellent imaging modality for breast cancer because it can provide important information complementary to that obtained from mammograms and because it is non-invasive, free of radiation hazard, and reproducible. While UDT promises several potentially important advantages over conventional ultrasonic imaging and has found important uses in a wide variety of engineering and scientific disciplines, its apphcation to breast imaging still remains largely unexplored. In the last year, our research on this project has, we believe, been successftil and productive. We have investigated, developed, and evaluated computationally efficient and statistically optimal algorithms for accurate reconstruction of UDT images that may find applications in UDT imaging of breast cancer. We have made contributions to UDT research, as summarized in the report, by addressing numerous scientific and engineering problems involved in UDT image reconstruction. These results are necessary in making UDT a viable medical technique for imaging of breast cancer.
SUBJECT TERMSultrasonic diffraction tomography, breast cancer detection Body 4
Key Research Accomplishments 7Reportable Outcomes 8
Conclusions 9References 10Appendices 11
IntroductionUltrasonic diffraction tomography (UDT) [1][2][3] can be viewed as a generalization of X-ray tomography where X-rays have been replaced with an acoustical wavefield. Because UDT is non-invasive, free of radiation hazard, and reproducible, it is potentially an excellent tool for imaging of breast cancer [4,5]. While UDT promises several potentially important advantages over conventional ultrasonic imaging and has found important uses in a wide variety of engineering and scientific disciplines, its appHcation to imaging of breast cancer still remains largely unexplored. The broad objective of the proposed project is to investigate, develop, and evaluate computationally efficient [6] and statistically optimal [7][8][9] algorithms for accurate image reconstruction in three-dimensional (3D) UDT imaging of the breast cancer. In the last year, our research on this project has, we believe, been successful and productive. The report below summarizes our research activities and results on the project to date.
BodyOur research activities on the project to date can be grouped naturally into 4 categories. The first was the investigation of efficient linear algorithms...