Image Resolution and Sensitivity Improvements of a Molecular Imaging Technique Based on Magnetic Nanoparticles

Ishihara, Yasutoshi; Kuwabara, Tsuyoshi; Wadamori, Naoki

doi:10.5772/20262

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…The magnetonanothermometer introduced herein will be useful in fast and remote temperature monitoring while using intra-extracellular hyperthermia and thermal-assisted drug/gene delivery technologies. Moreover, the magnetonanothermometer could be integrated with MPI technology to incorporate temperature capability into imaging because the MNP probe size is within the same range for both technologies, whereas the AC applied magnetic field frequencies may be set differently [20].…”

Section: Resultsmentioning

confidence: 99%

A fast and remote magnetonanothermometry for a liquid environment

Liu

Xie

et al. 2015

Meas. Sci. Technol.

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This study reports on a new approach for remote nanothermometry with short response time (milliseconds) aiming to operate in liquid media using AC susceptibility components of a suspended magnetic nanoparticle subjected to the Brownian relaxation mechanism. A simple, low cost, and accurate system was designed to measure AC susceptibility using an AC magnetic field at small amplitude (6 Oe) and frequency range (5 kHz) superimposed on a weak DC magnetic field (up to 30 Oe). A model based on the AC susceptibility of magnetic nanoparticles (30 nm average diameter) was constructed to describe the temperature measurement sensitivity of the dominated Brownian relaxation time. A new approach for remote nanothermometry was achieved with measured AC susceptibility by the designed system and the proposed model. Our experimental results show that our magnetonanothermometer allows temperature errors lower than 0.3 K with standard deviations lower than 0.1 K in the temperature range from 310 to 320 K.

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Section: Resultsmentioning

confidence: 99%

A fast and remote magnetonanothermometry for a liquid environment

Liu

Xie

et al. 2015

Meas. Sci. Technol.

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“…In order to confirm the validity of these numerical analysis procedures, a prototype system that collects onedimensional MPI image data was constructed [6]. In the experiment, FFP was formed with a gradient magnetic field of 1.2 T/m by a Maxwell coil pair (diameter: 180 mm, number of turns: 285 each, opposite distance: 30-50 mm).…”

Section: Validity Of Simulation Methodsmentioning

confidence: 99%

“…In all image reconstruction methods, the main reasons for image quality deterioration are that the gradient of the magnetic field distribution that forms a FFP is limited and that the magnetizing properties of MNPs are also imperfect [6]. This is because unnecessary interference signals from MNPs outside the selected region are detected at the same time.…”

Section: Introductionmentioning

confidence: 99%

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Correlation-Based Image Reconstruction Methods for Magnetic Particle Imaging

Ishihara

Kuwabara

Honma

et al. 2012

IEICE Trans. Inf. & Syst.

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SUMMARYMagnetic particle imaging (MPI), in which the nonlinear interaction between internally administered magnetic nanoparticles (MNPs) and electromagnetic waves irradiated from outside of the body is utilized, has attracted attention for its potential to achieve early diagnosis of diseases such as cancer. In MPI, the local magnetic field distribution is scanned, and the magnetization signal from MNPs within a selected region is detected. However, the signal sensitivity and image resolution are degraded by interference from magnetization signals generated by MNPs outside of the selected region, mainly because of imperfections (limited gradients) in the local magnetic field distribution. Here, we propose new methods based on correlation information between the observed signal and the system function-defined as the interaction between the magnetic field distribution and the magnetizing properties of MNPs. We performed numerical analyses and found that, although the images were somewhat blurred, image artifacts could be significantly reduced and accurate images could be reconstructed without the inverse-matrix operation used in conventional image reconstruction methods.

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Experimental Evaluation of Correlation-Based Image Reconstruction Method for Magnetic Particle Imaging

Honma

Ishihara

2012

Springer Proceedings in Physics

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Image Resolution and Sensitivity Improvements of a Molecular Imaging Technique Based on Magnetic Nanoparticles

Cited by 3 publications

References 9 publications

A fast and remote magnetonanothermometry for a liquid environment

A fast and remote magnetonanothermometry for a liquid environment

Correlation-Based Image Reconstruction Methods for Magnetic Particle Imaging

Experimental Evaluation of Correlation-Based Image Reconstruction Method for Magnetic Particle Imaging

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