Imagerie des dystrophies cornéennes : corrélations entre l’OCT en face de segment antérieur et la microscopie confocale in vivo

Ghouali, Wajdene; Hassani, Rachid Tahiri Joutei; Liang, Hong; Dupont-Monod, S.; Auclin, F.; Baudouin, Christophe; Labbé, Antoine

doi:10.1016/j.jfo.2014.10.015

Cited by 7 publications

(4 citation statements)

References 30 publications

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“…Siebelmann et al and El Sanharawi et al have investigated the features of corneal epithelial basement membrane dystrophy using anterior-segment optical coherence tomography (AS-OCT), they retained two main features on B-scan images of the cornea: the presence of an irregular and thickened epithelial basement membrane duplicating or insinuating into the corneal epithelium layer, or both, and the presence of hyperreflective dots (Fig 2) [8,9]. Moreover, Ghouali et al [10] used en-face OCT to characterise this dystrophy. En-face OCT clearly identified the appearance of fingerprints corresponding to the expansions and folds of the pathological basement membrane; intra-epithelial microcysts were also observed, whereas they were hardly visible on the axial section.…”

Section: Introductionmentioning

confidence: 99%

Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy

et al. 2020

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Purpose To investigate the corneal epithelial thickness topography with optical coherence tomography (OCT) and its relationship with vision quality in epithelial basement membrane dystrophy (EBMD). Methods 45 eyes of EBMD patients, 26 eyes of dry eye (DED) patients and 22 eyes of normal subjects were enrolled. All participants were subjected to 9-mm corneal epithelial mapping with OCT and vision quality was assessed with the optical quality analysis system using the objective scatter index (OSI). Central, superior, inferior, minimum, maximum, and standard deviation of epithelium thickness (Irregularity), were analysed and correlations with the OSI were calculated. Results The mean (±SD) central, inferior and maximum epithelial thicknesses of the EBMD patients (respectively, 56.4 (±8.1) μm, 58.9 (±6.4) μm, and 67.1 (±8.3) μm) were thicker compared to DED patients (P<0.05) and normal subjects (P<0.05). We found greater irregularity of epithelial thickness in EBMD (5.1±2.5 μm) compared to DED patients (2.6±1.0 μm) (P = 4.4.10−6) and normal subjects (2.1±0.7 μm) (P = 7.6.10−7). The mean OSI was worse in EBMD patients than in DED patients (P = 0.01) and compared to normal subjects (P = 0.02). The OSI correlated with the epithelial thickness irregularity (Spearman coefficient = 0.54; P = 2.65.10−5). Conclusions The OCT pachymetry map demonstrated that EBMD patients had thicker corneal epithelium in the central and inferior region. These changes were correlated with objective measurements of vision quality. This OCT characterisation of the EMBD provides a better understanding of the epithelial behaviour in this dystrophy and its role in vision quality.

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Section: Introductionmentioning

confidence: 99%

Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy

et al. 2020

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“…Optical coherence tomography (OCT) is a noninvasive imaging modality that uses interference of light to perform a high-resolution cross-sectional study of biological samples [ 6 ]. Another approach appeared with the use of en-face technology that compiles many transversal scans to provide frontal images [ 7 ].This imaging modality enables the assessment of various ocular surface diseases, most particularly conjunctiva/cornea tissue analysis [ 8 , 9 ]. This technology can also provide a good visualization of POV in the limbal region with no preparation or direct contact with the limbus [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

In vivo imaging of palisades of Vogt in dry eye versus normal subjects using en-face spectral-domain optical coherence tomography

et al. 2017

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PurposeTo evaluate a possible clinical application of spectral-domain optical coherence tomography (SD-OCT) using en-face module for the imaging of the corneoscleral limbus in normal subjects and dry eye patients.Patients and methodsSeventy-six subjects were included in this study. Seventy eyes of 35 consecutive patients with dry eye disease and 82 eyes of 41 healthy control subjects were investigated. All subjects were examined with the Avanti RTVue® anterior segment OCT. En-face OCT images of the corneoscleral limbus were acquired in four quadrants (inferior, superior, nasal and temporal) and then were analyzed semi-quantitatively according to whether or not palisades of Vogt (POV) were visible. En-face OCT images were then compared to in vivo confocal microscopy (IVCM) in eleven eyes of 7 healthy and dry eye patients.ResultsEn-face SD-OCT showed POV as a radially oriented network, located in superficial corneoscleral limbus, with a good correlation with IVCM features. It provided an easy and reproducible identification of POV without any special preparation or any direct contact, with a grading scale from 0 (no visualization) to 3 (high visualization). The POV were found predominantly in superior (P<0.001) and inferior (P<0.001) quadrants when compared to the nasal and temporal quadrants for all subjects examined. The visibility score decreased with age (P<0.001) and was lower in dry eye patients (P<0.01). In addition, the score decreased in accordance with the severity of dry eye disease (P<0.001).ConclusionEn-face SD-OCT is a non-contact imaging technique that can be used to evaluate the POV, thus providing valuable information about differences in the limbal anatomy of dry eye patients as compared to healthy patients.

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“…[11–13] Relatively quick and easy, OCT can not only be used for diagnosis and evaluation, but also for follow-up. The recent en face OCT allows fast analysis of large corneal areas, [14] which makes OCT a better tool for early detection of recurrence in the follow-up. Although our report is limited to EMBD, we believe that the advanced OCT will gain an expanding role in the category of corneal dystrophy, including EMBD.…”

Section: Discussionmentioning

confidence: 99%

A CARE-compliant article: optical coherence tomography for epithelial basement membrane dystrophy

Kuo

Lee

2019

Medicine

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Rationale: The etiology of anterior corneal opacities and the effect of debridement cannot be determined by biomicroscopy. Optical coherence tomography (OCT) helps identify the character and depth of these lesions. Patient concerns: A 45-year-old female complained of progressive blurred vision for a long time. Slit lamp biomicroscopy showed irregular, faint scar-like opacity of anterior cornea in her both eyes. Pentacam Scheimpflug camera tomography showed irregular astigmatism of anterior corneal surface. Anterior segment spectral-domain OCT revealed thickened, hyper-reflective linings, and scattered lesions, mainly in the epithelial layer. Diagnoses: Epithelial basement membrane dystrophy (EBMD). Intervention: Epithelial debridement and bandage lenses. Outcomes: The cornea became clear and the vision improved soon after debridement. The pathology showed thickened aberrant basement membrane extending into mid-epithelial layer, with microcyst-like lesions also noted. Lessons: OCT defines the depth of lesions and helps diagnosis and management of EBMD.

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Imagerie des dystrophies cornéennes : corrélations entre l’OCT en face de segment antérieur et la microscopie confocale in vivo

Cited by 7 publications

References 30 publications

Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy

Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy

In vivo imaging of palisades of Vogt in dry eye versus normal subjects using en-face spectral-domain optical coherence tomography

A CARE-compliant article: optical coherence tomography for epithelial basement membrane dystrophy

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