IMAGES: Nocardia pneumonia – A surprising and rare pulmonary infection mimicking lung cancer

Lopes, Kelly; Montenegro, C.; Vìlchez, J.; Camacho, M.E.; Marques, H.G.

doi:10.1016/j.pulmoe.2022.03.013

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…The resultant delayed appropriate treatment may have disastrous consequences. Nocardia lung abscess is easily misdiagnosed as lung cancer in clinical practice, especially when the disease continues to progress after antibiotic treatment in some patients ( 9 , 10 ). We report a case of a feverish patient with lung lesions that were suspected to be lung cancer after the disease progressed despite anti-inflammatory and antibiotic therapy.…”

Section: Introductionmentioning

confidence: 99%

Metagenome next-generation sequencing plays a key role in the diagnosis and selection of effective antibiotics on the treatment of Nocardia pneumonia: a case report

Fan,

Fang,

Huang

et al. 2024

Front. Med.

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Nocardia disease is an opportunistic infection, the occurrence is rare and mostly occurs in patients with immune deficiency. Even if the patient is immunocompetent, it can still be life-threatening. This case report describes a previously healthy 78-year-old male farmer with lung lesions discovered on a computerized tomography scan. Combined with the patient’s history of fever and the results of elevated laboratory markers associated with inflammation, the patient was diagnosed with a lung infection. After escalating empirical broad-spectrum antibiotics, antiviral and antifungal therapy, the patient continued to deteriorate to septic shock. In the meanwhile, the patient’s sputum was cultured repeatedly, and no obvious positive pathogenic bacteria were found. Considering the patient was elderly and that these lesions were solid with burr signs, as well as the progression after antimicrobial therapy cancer was considered in the differential diagnosis. Artificial intelligence (YITU, Hangzhou Yitu Medical Technology Limited Company) was also applied, and it also calculated that these lesions were cancerous. The patient received a puncture biopsy of the largest lung lesion. During the puncture pus was withdrawn from largest lung lesion. Culture and metagenome next-generation sequencing (mNGS) detection performed on pus indicated Nocardia otitidiscaviarum. The test report of the mNGS is also attached with a susceptibility report of commonly used clinical antibiotics to this Nocardia spp. Using this result, the patient’s disease was quickly controlled after selecting the targeted drug compound sulfamethoxazole and intravenous meropenem for treatment. In view of the high misdiagnosis rate and poor sensitivity of culture for Nocardia spp., this case emphasized mNGS playing a key role in the diagnosis and selection of effective antibiotics for the treatment of Nocardia spp. lung infections.

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Section: Introductionmentioning

confidence: 99%

Metagenome next-generation sequencing plays a key role in the diagnosis and selection of effective antibiotics on the treatment of Nocardia pneumonia: a case report

Fan,

Fang,

Huang

et al. 2024

Front. Med.

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Что Надо Знать О Редко Встречающихся Возбудителях Инфекций У Онкологических Больных?

Петухова,

Григорьевская,

Багирова

et al. 2024

Zlokač. opuholi

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Работа посвящена редко встречающимся бактериальным и грибковым возбудителям инфекций. Эти микроорганизмы создают трудности в диагностике и лечении в связи с возможными ошибками идентификации возбудителя, природной или приобретенной лекарственной резистентностью.Возбудители редких инфекций могут колонизировать больных, образовывать биопленки, персистировать в окружающей среде, передаваться от больного к больному и приводить к развитию вспышек инфекции. Они нередко ухудшают прогноз лечения онкологического больного и приводят к летальному исходу.Информация об особенностях редко встречающихся микроорганизмов и возможных подходах к их лечению позволит врачам-онкологам оказывать своевременную квалифицированную помощь подобным пациентам.

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Nocardia in an Immunocompetent Patient Simulating Pulmonary Carcinoma: A Case Report and Literature Review

Garcia Rueda,

García Rueda,

Bermúdez Flórez

et al. 2024

Cureus

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Nocardiosis is an opportunistic infectious pathology of low incidence that usually affects the lungs, skin, and brain. It has been implicated in causing serious and potentially fatal infections without treatment. It affects immunocompetent and immunocompromised patients. In immunocompetent patients, it is presented with local conditions, and in immunocompromised patients, it is seen in disseminated forms. We present the case of a 61-year-old male immunocompetent patient with a high suspicion of pulmonary carcinoma, in whom pathology showed infection by Nocardia spp.

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IMAGES: Nocardia pneumonia – A surprising and rare pulmonary infection mimicking lung cancer

Cited by 3 publications

References 6 publications

Metagenome next-generation sequencing plays a key role in the diagnosis and selection of effective antibiotics on the treatment of Nocardia pneumonia: a case report

Metagenome next-generation sequencing plays a key role in the diagnosis and selection of effective antibiotics on the treatment of Nocardia pneumonia: a case report

Что Надо Знать О Редко Встречающихся Возбудителях Инфекций У Онкологических Больных?

Nocardia in an Immunocompetent Patient Simulating Pulmonary Carcinoma: A Case Report and Literature Review

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