Imagination Laboratory: Making Sense of Bio-Objects in Contemporary Genetic Art

Holmberg, Tora; Ideland, Malin

doi:10.1111/1467-954x.12387

Cited by 11 publications

(4 citation statements)

References 50 publications

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“…Finally, (bio)artists are particularly well positioned to explain or visualize scientific work, 38 to critically question the TE field, its implications and assumptions 215 , 250 and to provide alternative places for discourse on the intersection of art and bioethics. 222 , 251 …”

Section: Resultsmentioning

confidence: 99%

The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

Kanter

Jongsma

Verhaar

et al. 2023

Tissue Engineering Part B: Reviews

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Tissue Engineering (TE) is a branch of Regenerative Medicine (RM) that combines stem cells and biomaterial scaffolds to create living tissue constructs to restore patients' organs after injury or disease. Over the last decade, emerging technologies such as 3D bioprinting, biofabrication, supramolecular materials, induced pluripotent stem cells, and organoids have entered the field. While this rapidly evolving field is expected to have great therapeutic potential, its development from bench to bedside presents several ethical and societal challenges. To make sure TE will reach its ultimate goal of improving patient welfare, these challenges should be mapped out and evaluated. Therefore, we performed a systematic review of the ethical implications of the development and application of TE for regenerative purposes, as mentioned in the academic literature. A search query in PubMed, Embase, Scopus, and PhilPapers yielded 2451 unique articles. After systematic screening, 237 relevant ethical and biomedical articles published between 2008 and 2021 were included in our review. We identified a broad range of ethical implications that could be categorized under 10 themes. Seven themes trace the development from bench to bedside: (1) animal experimentation, (2) handling human tissue, (3) informed consent, (4) therapeutic potential, (5) risk and safety, (6) clinical translation, and (7) societal impact. Three themes represent ethical safeguards relevant to all developmental phases: (8) scientific integrity, (9) regulation, and (10) patient and public involvement. This review reveals that since 2008 a significant body of literature has emerged on how to design clinical trials for TE in a responsible manner. However, several topics remain in need of more attention. These include the acceptability of alternative translational pathways outside clinical trials, soft impacts on society and questions of ownership over engineered tissues. Overall, this overview of the ethical and societal implications of the field will help promote responsible development of new interventions in TE and RM. It can also serve as a valuable resource and educational tool for scientists, engineers, and clinicians in the field by providing an overview of the ethical considerations relevant to their work. Impact statement To our knowledge, this is the first time that the ethical implications of Tissue Engineering (TE) have been reviewed systematically. By gathering existing scholarly work and identifying knowledge gaps, this review facilitates further research into the ethical and societal implications of TE and Regenerative Medicine (RM) and other emerging biomedical technologies. Moreover, it will serve as a valuable resource and educational tool for scientists, engineers, and clinicians in the field by providing an overview of the ethical considerations relevant to their work. As such, our review may promote successful and responsible development of new strategies in TE and RM.

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Section: Resultsmentioning

confidence: 99%

The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

Kanter

Jongsma

Verhaar

et al. 2023

Tissue Engineering Part B: Reviews

View full text Add to dashboard Cite

show abstract

“…The cultural institution of art is generally considered providing a predestined experimenting ground for synthesis of different ideas, practises and technologies (Holmberg & Ideland, 2016;Borchhardt, 2020). According to this institution's traditional, (self-) proclaimed social function as a special space of experimentation, reflection, and experience with its own aesthetic, social, and legal regularities in various countries, many artists and researchers use the art institution to criticize traditional notions of order and point out aesthetic and material alternatives through an unconventional experimental use of technologies, cultural practices, and artistic strategies of staging.…”

Section: Imagining Godzillamentioning

confidence: 99%

Metahumanism, Euro-Transhumanism and Sorgner’s Philosophy. Technology, Ethics, Art

2024

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This essay collection is a fascinating, thorough, and intellectually stimulating analysis of Stefan Lorenz Sorgner’s theoretical frameworks and conceptualizations of Euro-transhumanism, metahumanism, and the philosophy of posthuman art. The contributors address the most challenging philosophical, ethical, and aesthetic issues in the field of trans-, critical post- and metahumanism, such as debates concerning Nietzsche as a weak proto-transhumanist, potential risks and benefits of artificial intelligence, brain-computer interfaces and (bio)enhancements, ecological crises, space travel, the use of human embryos for artistic purposes, robots as artists, humans as cyborgs, and more. This collection provides a critical introduction to Sorgner’s philosophy as well as a complex intellectual engagement with the field of posthuman studies. It is a rich reflective journey for all those interested in technology, ethics, art, and the posthuman paradigm shift.

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“…Like science, art is concerned with creation and control, but often at a different level and for different ends. It also contains centrally elements of playfulness, encouraging imagination and wonder [54][55][56], which according to Nussbaum ([54]: p. 100) have an 'important role in shaping democratic citizenship'.…”

Section: Embracing the Messy: Artists Counter The Standardisation Of mentioning

confidence: 99%

Living Machines: Metaphors We Live By

Vaage

2019

Nanoethics

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Within biology and in society, living creatures have long been described using metaphors of machinery and computation: 'bioengineering', 'genes as code' or 'biological chassis'. This paper builds on Lakoff and Johnson's (1980) argument that such language mechanisms shape how we understand the world. I argue that the living machines metaphor builds upon a certain perception of life entailing an idea of radical human control of the living world, looking back at the historical preconditions for this metaphor. I discuss how design is perceived to enable us to shape natural beings to our will, and consider ethical, epistemological and ontological implications of the prevalence of this metaphor, focusing on its use within synthetic biology. I argue that we urgently need counter-images to the dominant metaphor of living machines and its implied control and propose that artworks can provide such counterimages through upsetting the perception of life as controllable. This is argued through discussion of artworks by Oron Catts and Ionat Zurr, by Tarsh Bates and by Ai Hasegawa, which in different ways challenge mechanistic assumptions through open-ended engagement with the strangeness and messiness of life.

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Imagination Laboratory: Making Sense of Bio-Objects in Contemporary Genetic Art

Cited by 11 publications

References 50 publications

The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

Metahumanism, Euro-Transhumanism and Sorgner’s Philosophy. Technology, Ethics, Art

Living Machines: Metaphors We Live By

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