2013
DOI: 10.1002/mrm.24953
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Imaging amide proton transfer and nuclear overhauser enhancement using chemical exchange rotation transfer (CERT)

Abstract: Purpose This study investigates amide proton transfer (APT) and nuclear overhauser enhancement (NOE) in phantoms and 9L tumors in rat brains at 9.4 Tesla, using a recently developed method that can isolate different contributions to exchange. Methods Chemical exchange rotation transfer (CERT) was used to quantify APT and NOEs through subtraction of signals acquired at two irradiation flip angles, but with the same average irradiation power. Results CERT separates and quantifies specific APT and NOE signals… Show more

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Cited by 65 publications
(117 citation statements)
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References 22 publications
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“…Other experiments like VDMP-CEST [18] make use of variable spacing between labeling pulses to selectively bias signals depending on their transfer rate. Another method, CERT [21], encodes transfer rate information in the flip angle that a B 1 field can impose prior to transfer, but these approaches cannot actively suppress slowly exchanging signals as is done in TRE-CEST. In contrast, the FLEX method of frequency labeling can selectivity remove slowly transferring components by keeping the total evolution time T of the frequency labeling LTM short enough that magnetization transfer is unlikely to occur to a significant degree, but this approach ultimately comes at the expense of spectral resolution.…”
Section: Resultsmentioning
confidence: 99%
“…Other experiments like VDMP-CEST [18] make use of variable spacing between labeling pulses to selectively bias signals depending on their transfer rate. Another method, CERT [21], encodes transfer rate information in the flip angle that a B 1 field can impose prior to transfer, but these approaches cannot actively suppress slowly exchanging signals as is done in TRE-CEST. In contrast, the FLEX method of frequency labeling can selectivity remove slowly transferring components by keeping the total evolution time T of the frequency labeling LTM short enough that magnetization transfer is unlikely to occur to a significant degree, but this approach ultimately comes at the expense of spectral resolution.…”
Section: Resultsmentioning
confidence: 99%
“…Three recent dedicated CEST workshops (3rd, 4th, and 5th international CEST workshops in Annapolis, 2012, Torino, 2014, and Philadelphia 2016) drew about 90-200 registrants. The last decade has shown major developments for paraCEST agents, 14,15,20,89,90,119,[135][136][137][138][139][140][141][142][143][144][145][146][147][148] diaCEST agents, 12,13,17,42,43,68,72,88,102,116,125,128,[149][150][151][152][153][154][155][156][157][158][159][160] and even hyperpolarized (hyperCEST) agents. 161,162 This is not surprising in view of the number of potential applications including pH imaging, metabolite detection, ion detection, cellular protein and peptide imaging, cell labeling, temperature i...…”
Section: Potential and Clinical Translation Of Cest Methodsmentioning
confidence: 99%
“…This is generally the case at high B 0 but often not at 1.5 and 3 T. An example of clean editing is shown in Figure 11, where the CERT effects (difference of 300 2π-pulses and 600 π pulses with B 1 = 1.6 μT and t sat (π) = 6.8 ms) in a 9L glioma model are compared with conventional APTw MTR asym measures. 102 While showing a clear pure APT increase in tumor for the parameters used, MTR double is much smaller than the APTw MRI increase based on asymmetry analysis. This arises because the APTw MRI is contaminated with asymmetric contributions due to rNOEs and MTC.…”
Section: Exchange Transfer Sequences Employing Excitationmentioning
confidence: 99%
See 1 more Smart Citation
“…We incorporate a recent advance using inverse or reciprocal subtraction to correct for DS, semi-solid MT effects, and water relaxation (14), as utilized by the previously introduced AREX metric (15). Here we introduce a new metric, AREX double,vdc , which combines the use of a single frequency offset (as in CERT methods and the MTR double metric (8,16)) with the inverse subtraction approach (as in AREX (14)). In this way, we minimize contributions from MT asymmetry and rNOE effects (via single frequency acquisition) and DS and semi-solid MT effects (via inverse subtraction).…”
Section: Introductionmentioning
confidence: 99%