Imaging Appearance in Acute Liver Failure: Correlation with Clinical and Pathology Findings

Romero, Míriam; Palmer, Suzanne; Kahn, Jeffrey; Ihde, Lauren; Lin, Leah; Kosco, Anne; Shinar, Ron; Ghandforoush, Aslan; Chan, Linda S.; Petrovic, Lydia M.; Sher, Linda; Fong, Tse‐Ling

doi:10.1007/s10620-014-3106-6

Cited by 30 publications

(21 citation statements)

References 13 publications

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“…ALF is the situation that occurs when there is severe acute liver injury, with necrosis of most hepatocytes without clear and rapid regeneration in a previously normal liver, and which causes severe changes in coagulation, with a clinical picture of encephalopathy and coma [2][3]. It manifests itself as a rare, multiple etiology syndrome with similar clinical conditions.…”

Section: Introductionmentioning

confidence: 99%

Action of Melatonin on Severe Acute Liver Failure in Rats

Salvi¹,

Schemitt²,

Colares³

et al. 2017

IOSRJPBS

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Abstract:Severe acute liver failure (ALF) manifests itself as a rare syndrome, with multiple etiologies for similar clinical conditions. Melatonin (MLT) is a lipophilic indolamine that is synthesized in the pineal gland from serotonin. This study was designed to evaluate hepatic changes resulting from the thioacetamide-induced ALF model, as well as the effects of MLT treatment in male Wistar rats (n = 56) in 24-and 48-h experiments. The results indicate a hepatoprotective effect of MLT, with no difference between the studied times, and increased animal survival.

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Section: Introductionmentioning

confidence: 99%

Action of Melatonin on Severe Acute Liver Failure in Rats

Salvi¹,

Schemitt²,

Colares³

et al. 2017

IOSRJPBS

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“…In addition to that, due to the incorporated DAu within DPSi/DAu@AcDEX, we may apply the “Trojan horse” strategy into lesion detection and characterization. Early ALF lacks of a proper bioimaging‐guided diagnostic method due to the initial damage may not induce detectable morphology changes in liver, thus introducing a proper contrasting agent is rather crucial . Au NPs induce a strong X‐ray attenuation and obsess unique physical, chemical, and biological properties, which make them an ideal candidate as CT‐contrasting agents.…”

mentioning

confidence: 99%

Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

Liu

et al. 2017

Advanced Materials

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Herein, a novel nanohybrid based on porous silicon, gold nanoparticles (Au NPs), and acetalated dextran (DPSi/DAu@AcDEX) is reported to encapsulate and deliver one drug and increase the computer tomography (CT) signal for acute-liver-failure (ALF) theranostics. A microfluidic-assisted method is used to co-encapsulate different NPs in a single step. By alternating the surface properties of different NPs and by modulating the composition of the organic phase, both PSi and Au NPs are effectively encapsulated into the polymer matrix simultaneously, thus further achieving a multifunctional application. This system can be used to identify pathologically changes in the tissues and selectively deliver drugs to these sites. The loading of a therapeutic compound (XMU-MP-1) improves the drug solubility, precise, in situ drug delivery, and the drug-functioning time. In vivo results confirm a superior treatment effect and better compliance of this newly developed nanoformulation than free compound. This nanosystem plays a crucial role in targeting the lesion area, thus increasing the local drug concentration important for ALF reverse-effect. Moreover, the residence of Au NPs within the matrix further endows our system for CT-imaging. Altogether, these results support that this nanohybrid is a potential theranostic platform for ALF.

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“…These findings are in accordance with Romero et al . , who demonstrated that the majority of patients with ALF had abnormal radiographic findings. Liver surface nodularity correlated with massive hepatic necrosis on histology, and with wrinkled capsule on visual inspection of the explanted liver specimen .…”

Section: Discussionmentioning

confidence: 71%

Cyproterone acetate induces a wide spectrum of acute liver damage including corticosteroid‐responsive hepatitis: report of 22 cases

Bessone

Lucena

Roma

et al. 2015

Liver International

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Imaging Appearance in Acute Liver Failure: Correlation with Clinical and Pathology Findings

Abstract: Imaging findings in ALF was variable and can resemble cirrhosis. Assessment for underlying cirrhosis in the setting of liver failure should not be based on imaging findings.

Cited by 30 publications

References 13 publications

Action of Melatonin on Severe Acute Liver Failure in Rats

Action of Melatonin on Severe Acute Liver Failure in Rats

Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

Cyproterone acetate induces a wide spectrum of acute liver damage including corticosteroid‐responsive hepatitis: report of 22 cases

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