Imaging-based predictors for hyperbaric oxygen therapy outcome in post-stroke patients. Report 1

Golan, Hava M.; Makogon, B; Volkov, Olga; Smolyakov, Yu. N.; Hadanny, Amir; Efrati, Shai

doi:10.1016/j.mehy.2019.109510

Cited by 12 publications

(8 citation statements)

References 39 publications

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“…Similarly, perfusion SPECT can be useful in assessing response to treatment or interventions ( 136 , 137 ). A smaller volume of penumbra ( 138 ) and the absence of crossed cerebellar diaschisis ( 139 ) can be predictive of better clinical response. The technical improvements in gamma cameras and in post-processing software have markedly improved the resolution, anatomical detail, and information density of perfusion SPECT scans ( Figure 6 ).…”

Section: Assessment Of the State Of The Art—spect In Brain Disordersmentioning

confidence: 99%

The Legacy of the TTASAAN Report—Premature Conclusions and Forgotten Promises: A Review of Policy and Practice Part I

2022

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Brain perfusion single photon emission computed tomography (SPECT) scans were initially developed in 1970's. A key radiopharmaceutical, hexamethylpropyleneamine oxime (HMPAO), was originally approved in 1988, but was unstable. As a result, the quality of SPECT images varied greatly based on technique until 1993, when a method of stabilizing HMPAO was developed. In addition, most SPECT perfusion studies pre-1996 were performed on single-head gamma cameras. In 1996, the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology (TTASAAN) issued a report regarding the use of SPECT in the evaluation of neurological disorders. Although the TTASAAN report was published in January 1996, it was approved for publication in October 1994. Consequently, the reported brain SPECT studies relied upon to derive the conclusions of the TTASAAN report largely pre-date the introduction of stabilized HMPAO. While only 12% of the studies on traumatic brain injury (TBI) in the TTASAAN report utilized stable tracers and multi-head cameras, 69 subsequent studies with more than 23,000 subjects describe the utility of perfusion SPECT scans in the evaluation of TBI. Similarly, dementia SPECT imaging has improved. Modern SPECT utilizing multi-headed gamma cameras and quantitative analysis has a sensitivity of 86% and a specificity of 89% for the diagnosis of mild to moderate Alzheimer's disease—comparable to fluorodeoxyglucose positron emission tomography. Advances also have occurred in seizure neuroimaging. Lastly, developments in SPECT imaging of neurotoxicity and neuropsychiatric disorders have been striking. At the 25-year anniversary of the publication of the TTASAAN report, it is time to re-examine the utility of perfusion SPECT brain imaging. Herein, we review studies cited by the TTASAAN report vs. current brain SPECT imaging research literature for the major indications addressed in the report, as well as for emerging indications. In Part II, we elaborate technical aspects of SPECT neuroimaging and discuss scan interpretation for the clinician.

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Section: Assessment Of the State Of The Art—spect In Brain Disordersmentioning

confidence: 99%

The Legacy of the TTASAAN Report—Premature Conclusions and Forgotten Promises: A Review of Policy and Practice Part I

2022

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“…Recently, a retrospective analysis was performed on 62 consecutive patients prescribed for HBOT after stroke. 169 Results of this study showed that some patients ( n = 24) significantly benefitted from HBOT by improving their clinical neurological status and quality of life.…”

Section: Linical T Rialsmentioning

confidence: 79%

A review on the neuroprotective effects of hyperbaric oxygen therapy

Ahmadi

Khalatbary

2021

Medical Gas Research

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Hyperbaric oxygen therapy, intermittent breathing of 100% oxygen at a pressure upper than sea level, has been shown to be some of the neuroprotective effects and used therapeutically in a wide range of neurological disorders. This review summarizes current knowledge about the neuroprotective effects of hyperbaric oxygen therapy with their molecular mechanisms in different models of neurological disorders.

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“…The advantages and drawbacks of various imaging techniques available for stroke are compared in Table 1 . X-ray CT is the first widely used imaging test to identify lesions for disease diagnosis which can be combined with PET and SPECT [ 12 , 13 ] to increase specificity and performances of functional imaging. However, these methods utilize ionizing radiation to obtain images inside the body, resulting in safety issues when frequently used.…”

Section: Stroke Imagingmentioning

confidence: 99%