Imaging biomarkers associated with extra-axial intracranial tumors: a systematic review

Wijethilake, Navodini; MacCormac, Oscar; Vercauteren, Tom; Shapey, Jonathan

doi:10.3389/fonc.2023.1131013

Cited by 1 publication

(1 citation statement)

References 102 publications

(196 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, pituitary neuroendocrine tumors (PitNETs), the second most common primary brain tumors, originate in the sellar region. 8 , 9 These tumors compress surrounding brain tissue 10 , 11 and exhibit abnormal hormone secretion.…”

Section: Introductionmentioning

confidence: 99%

Pituitary neuroendocrine tumor: A neuropsychological comparison with intra‐axial tumor

Tang,

Fang,

Bie

et al. 2024

Ann Clin Transl Neurol

View full text Add to dashboard Cite

ObjectiveDespite pituitary neuroendocrine tumor (PitNET) being extra‐axial tumors without direct damage to brain tissue, patients with PitNET exhibit neuropsychological impairments. However, it remains unclear whether there are neuropsychological differences between PitNET and intra‐axial tumors that directly destroy the brain parenchyma. This prospective study aims to clarify this distinction to inform decision‐making for intracranial tumors of diverse origins.MethodsA total of 146 patients with PitNET, 74 patients with glioma representing intra‐axial tumors, and 52 age‐, sex‐, and education‐matched healthy controls were recruited. All patients received standard treatment and postoperative rehabilitation. Clinical data were meticulously collected, and neuropsychological tests were administered to all participants both before and 3 months after surgery.ResultsBoth PitNET and glioma patients experience the dual burden of cognitive and affective deficits. However, the feature of these deficits differs substantially. In PitNET patients, the deficits are relatively mild and focal, whereas in glioma patients, they are severe and extensive. Specifically, PitNET patients exhibit deficits in memory, anxiety, and negative affect. In contrast, glioma patients display deficits in executive function, attention, anxiety, positive/negative affect, and empathy. Notably, except for persistent memory deficits, the majority of neuropsychological scores declines in PitNET patients are restorable and can reach improvement within a short period after standard surgical therapy and perioperative management. Conversely, glioma patients not only fail to show improvements but also demonstrate worsening in terms of general cognition and memory postoperatively.InterpretationAs an extra‐axial tumor, PitNET may exhibit distinctive cognitive and affective functioning compared to intra‐axial tumors, highlighting the need for specific treatment approaches for PitNET patients.

show abstract