Imaging brain tumor by dendrimer-based optical/paramagnetic nanoprobe across the blood-brain barrier

Yan, Huihui; Wang, Jiyao; Yi, Peiwei; Lei, Hao; Zhan, Changyou; Xie, Conghua; Feng, Liang; Qian, Jun; Zhu, Jiaan; Lu, Weiyue; Liu, Cong

doi:10.1039/c1cc12007g

Cited by 62 publications

(55 citation statements)

References 21 publications

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“…PAMAM dendrimers have great potential as carriers of anticancer drugs (Cui et al, 2009) and for gene delivery (Huang et al, 2007;Ke et al, 2009). In addition, dendrimer-based optical/paramagnetic nano probes can cross the bloodbrain barrier and be used for imaging of brain tumors (Yan et al, 2011). Usage of PAMAM dendrimers during pregnancy may trigger transplacental transfer to fetus and infants were also exposed to PAMAM dendrimers from environment.…”

Section: Introductionmentioning

confidence: 99%

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells

et al. 2016

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-Polyamidoamine (PAMAM) dendrimers have potential for biological applications as delivery systems for genes, drugs, and imaging agents into the brain, but their developmental neurotoxicity remains unknown. We investigated the effects of PAMAM dendrimers with various surface functional groups and multiple generations on neuronal differentiation using human neural progenitor cells at an equal mass concentration. Only PAMAM dendrimers containing amine (NH 2 ) surface groups at concentrations of 10 μg/mL significantly reduced cell viability and neuronal differentiation, compared with non-amine-terminated dendrimers. PAMAM-NH 2 with generation (G)3, G4, G5 G6, and G7 significantly decreased cell viability and inhibited neuronal differentiation from a concentration of 5 μg/mL, but G0, G1, and G2 dendrimers did not have any effect at this concentration. Cytotoxicity indices of PAMAM-NH 2 dendrimers at 10 μg/mL correlated well with the zeta potentials of the particles. Surface group density and particle number in unit volume is more important characteristic than particle size to influence cytotoxicity for positive changed dendrimers. PAMAM-50% C 12 at 1 μg/mL altered the expression level of the oxidative stress-related genes, ROR1, CYP26A1, and TGFB1, which is a DNA damage response gene. Our results indicate that PAMAM dendrimer exposure may have a surface charge-dependent adverse effect on neuronal differentiation, and that the effect may be associated with oxidative stress and DNA damage during development of neural cells.

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Section: Introductionmentioning

confidence: 99%

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells

et al. 2016

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“…Angiopep-2 is therefore frequently chosen as the BBB-permeable ligand for nanoparticle delivery to the brain. Li and co-workers [109] conjugated angiopep-2 to a dendrimer of generation 5, along with the MRI reporter Gd-DTPA and the fluorescent dyes Cy5.5 and rhodamine, to create a dual MRI/fluorescent imaging agent (Fig. 14a).…”

Section: Reviewsmentioning

confidence: 99%

Dendrimer-based magnetic resonance imaging agents for brain cancer

et al. 2018

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Brain cancer is one of the most lethal and difficult-to-treat cancers because of its physical location and biological barriers. The mainstay of brain cancer treatment is surgical resection, which demands precise imaging for tumor localization and delineation. Thanks to advances in bioimaging, brain cancer can be detected earlier and resected more reliably. Magnetic resonance imaging (MRI) is the most common and preferred method to delineate brain cancer, and a contrast agent is often required to enhance imaging contrast. Dendrimers, a special family of synthetic macromolecules, constitute a particularly appealing platform for constructing MRI contrast agents by virtue of their well-defined three-dimensional structure, tunable nanosize and abundant surface terminals, which allow the accommodation of high payloads and numerous functionalities. Tuning the dendrimer size, branching and surface composition in conjunction with conjugation of MRI functionalities and targeting moieties can alter the relaxivity for MRI, overcome the blood-brain barrier and enhance tumor-specific targeting, hence improving the imaging quality and safety profile for precise and accurate imaging of brain tumors. This short review highlights the recent progress, opportunities and challenges in developing dendrimer-based MRI contrast agents for brain tumor imaging.

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“…PAMAM dendrimer generations 1-8 have been functionalized with gadolinium and rhodamine B for both magnetic resonance and fluorescence imaging of malignant gliomas. Several more attempts have been made to generate dendrimer-based imaging nanoprobes, including a dendrimer-PEG copolymer-based architecture for fluorescence sensing, imaging for the first time extracellular pH in the brain in a mouse epilepsy model [68]; a dendrimer-based optical/paramagnetic nanoprobe, which showed a capability to circumvent the BBB and yielded high sensitivity images of brain tumors in vivo [69] and the use of dendritic phosphorescent probes for oxygen imaging in rat brains [70].…”

Section: Imaging and Diagnosismentioning

confidence: 99%

Nanoparticles for Brain-Specific Drug and Genetic Material delivery, Imaging and Diagnosis

Posadas

Monteagudo

Ceña

2016

Nanomedicine (Lond.)

108

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The poor access of therapeutic drugs and genetic material into the central nervous system due to the presence of the blood-brain barrier often limits the development of effective noninvasive treatments and diagnoses of neurological disorders. Moreover, the delivery of genetic material into neuronal cells remains a challenge because of the intrinsic difficulty in transfecting this cell type. Nanotechnology has arisen as a promising tool to provide solutions for this problem. This review will cover the different approaches that have been developed to deliver drugs and genetic material efficiently to the central nervous system as well as the main nanomaterials used to image the central nervous system and diagnose its disorders.

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Imaging brain tumor by dendrimer-based optical/paramagnetic nanoprobe across the blood-brain barrier

Cited by 62 publications

References 21 publications

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells

Dendrimer-based magnetic resonance imaging agents for brain cancer

Nanoparticles for Brain-Specific Drug and Genetic Material delivery, Imaging and Diagnosis

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