“…However, these sequences are still relatively insensitive to CL at 1.5 T and 3 T ( Müller et al, 2022 , Kilsdonk et al, 2016 , Beck et al, 2020 ). Ultra-high field MRI, with its higher signal-to-noise ratio and increased susceptibility effects, has proven to be a powerful tool for increasing the sensitivity to CL, especially for intracortical and subpial lesions ( Madsen et al, 2021 , Beck et al, 2022 , Maranzano et al, 2019 ). Even with the most sensitive methods, however, CL are small and often subtle, making manual segmentation extremely time consuming and subject to relatively low inter-rater reliability ( Harrison et al, 2015 , Faizy et al, 2017;12(2):e0172923.…”