2021
DOI: 10.1101/2021.06.25.21259363
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Imaging cortical multiple sclerosis lesions with ultra-high field MRI

Abstract: Background: Cortical lesions are abundant in multiple sclerosis (MS), yet difficult to visualize in vivo. Ultra- high field (UHF) MRI at 7T and above provides technological advances suited to optimize the detection of cortical lesions in MS. Purpose: To provide a narrative and quantitative systematic review of the literature on UHF MRI of cortical lesions in MS. Methods: A systematic search of all literature on UHF MRI of cortical lesions in MS published before September 2020. Quantitative outcome measures inc… Show more

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“…However, these sequences are still relatively insensitive to CL at 1.5 T and 3 T ( Müller et al, 2022 , Kilsdonk et al, 2016 , Beck et al, 2020 ). Ultra-high field MRI, with its higher signal-to-noise ratio and increased susceptibility effects, has proven to be a powerful tool for increasing the sensitivity to CL, especially for intracortical and subpial lesions ( Madsen et al, 2021 , Beck et al, 2022 , Maranzano et al, 2019 ). Even with the most sensitive methods, however, CL are small and often subtle, making manual segmentation extremely time consuming and subject to relatively low inter-rater reliability ( Harrison et al, 2015 , Faizy et al, 2017;12(2):e0172923.…”
Section: Cortical Lesions Paramagnetic Lesions and Central Vein Signmentioning
confidence: 99%
“…However, these sequences are still relatively insensitive to CL at 1.5 T and 3 T ( Müller et al, 2022 , Kilsdonk et al, 2016 , Beck et al, 2020 ). Ultra-high field MRI, with its higher signal-to-noise ratio and increased susceptibility effects, has proven to be a powerful tool for increasing the sensitivity to CL, especially for intracortical and subpial lesions ( Madsen et al, 2021 , Beck et al, 2022 , Maranzano et al, 2019 ). Even with the most sensitive methods, however, CL are small and often subtle, making manual segmentation extremely time consuming and subject to relatively low inter-rater reliability ( Harrison et al, 2015 , Faizy et al, 2017;12(2):e0172923.…”
Section: Cortical Lesions Paramagnetic Lesions and Central Vein Signmentioning
confidence: 99%