Imaging diagnosis of bile duct cystadenocarcinoma

Takayasu, Kenichi; Muramatsu, Yukio; Moriyama, Noriyuki; Yamada, Tatsuya; Hasegawa, Hiroshi; Hirohashi, Setsuo; Ichikawa, Tadashi; Ohno, Giichiro

doi:10.1002/1097-0142(19880301)61:5<941::aid-cncr2820610514>3.0.co;2-0

Cited by 46 publications

(43 citation statements)

References 10 publications

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“…6 Typically, the epithelial cells of the tumor lesion share the cytokeratin pattern with bile duct cells, supporting the view that hepatobiliary cystadenocarcinoma originates from bile duct cells. 13 The adenoma-adenocarcinoma sequence has been emphasized with respect to the carcinogenesis of cystadenocarcinoma.…”

Section: Discussionmentioning

confidence: 71%

Hepatobiliary cystadenocarcinoma with rapid growth: report of a case

Kudo¹,

Kikuchi²,

Sato³

et al. 2008

J Med Ultrasonics

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We describe a case of histologically proven hepatobiliary cystadenocarcinoma with an emphasis on the longterm clinical course. The patient was a 75-year-old man who had been diagnosed as having a simple hepatic cyst at our hospital and had been followed up by abdominal sonography (US) for about 10 years. However, the lesion subsequently showed a sudden increase in size and a marked change in US findings, i.e., from a benign hepatic cyst to a complete solid lesion. Contrast-enhanced US revealed the lesion to be filled with fine vessels. This rapid change led us to strongly suspect a hepatobiliary cystadenocarcinoma and, thus, left lateral segmentectomy was performed. The patient is doing well 6 months after the surgical treatment.

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Section: Discussionmentioning

confidence: 71%

Hepatobiliary cystadenocarcinoma with rapid growth: report of a case

Kudo¹,

Kikuchi²,

Sato³

et al. 2008

J Med Ultrasonics

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“…Besides intraductal neoplasm, the differential diagnosis of regional biliary ductal obstruction includes calculus disease, sclerosing cholangitis, metastatic disease, hepatoma, and hepatic cysts. 4,9,19 In this case, radiological findings of asymmetric bile duct dilatation in the absence of identifiable calculi and segmental hepatic atrophy favor a diagnosis of an intraductal neoplasm, such as hilar cholangiocarcinoma or extrahepatic bile duct cancer.…”

Section: Discussionmentioning

confidence: 77%

Successful surgical management of an extrahepatic biliary cystadenocarcinoma

et al. 2011

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Extrahepatic bile duct cancer is an uncommon disease, and few cases are curable by surgery. We report a case of extrahepatic biliary cystadenocarcinoma (BCAC) associated with atrophy of the left hepatic lobe. A 54-year old male was admitted with painless obstructive jaundice and a hepatic palpable mass noticed one month before presentation. Liver functions tests were consistent with cholestatic damage and serum carbohydrate antigen 19.9 (CA 19-9) was increased before treatment. Magnetic resonance imaging (MRI) disclosed dilatation of the left hepatic bile duct with irregular wall thickening close to the hepatic confluence, and atrophy of left hepatic lobe. The patient was submitted to en bloc extended left hepatectomy with resection of caudate lobe, hilar lymphadenectomy, and suprapancreatic biliary tree resection. All surgical margins were grossly negative, and postoperative course was uneventful, except for a minor bile leak. The patient was discharged on the 15th postoperative day; he is alive without tumor recurrence one year after primary therapy. Although technically challenging, extended en bloc resection is feasible in adults with extrahepatic BCAC and can improve survival with acceptable and manageable morbidity.

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“…Angiographically, cystadenomas are hypovascular lesions. Takayasu et al 12 reported that findings suggestive of malignancy were the stretching of thin hepatic arteries, irregular calibers of the peripheral arteries in the arterial phase, and stains in the parenchymal phase. A light tumor stain was seen in our patient, suggestive of malignancy.…”

Section: Discussionmentioning

confidence: 99%

Extrahepatic biliary cystadenocarcinoma arising from the left hepatic duct

Kimura

Kagawa

Deguchi

et al. 1998

Journal of Gastroenterology

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A 54-year-old man, who had no clinical symptoms, underwent a routine health checkup at our hospital. Abdominal ultrasonography disclosed a well demarcated tumor containing a solid portion occupying the dilated left hepatic duct and a cystic portion expanding into the parenchyma of the left hepatic lobe, with mild dilatation of the intrahepatic bile ducts. These findings were later confirmed by computed tomography (CT) and magnetic resonance imaging. Endoscopic retrograde cholangiography revealed a complete defect at the level of the left hepatic duct, while drip infusion cholangiographic-CT (DIC-CT) disclosed a defect of the left hepatic duct only, with the distal portions of the left intrahepatic ducts being visualized on the image. Hepatic angiography revealed light stains in the solid portion in the parenchymal phase. At left lobectomy, a multiloculated polyp-like tumor was found arising from the left hepatic duct and expanding into the parenchyma of the left hepatic lobe. Microscopically, all the lining cells in the cysts and the tumor cells in the solid portion showed the features of papillary adenocarcinoma. In this patient with extrahepatic biliary cystadenocarcinoma, DIC-CT was useful in identifying the site of origin of the tumor, and hepatic angiography was also useful in differentiating this rare malignant tumor from benign cystadenoma.

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Imaging diagnosis of bile duct cystadenocarcinoma

Cited by 46 publications

References 10 publications

Hepatobiliary cystadenocarcinoma with rapid growth: report of a case

Hepatobiliary cystadenocarcinoma with rapid growth: report of a case

Successful surgical management of an extrahepatic biliary cystadenocarcinoma

Extrahepatic biliary cystadenocarcinoma arising from the left hepatic duct

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