Imaging evolution of the primate brain: the next frontier?

Friedrich, Patrick; Forkel, Stephanie J.; Amiez, Céline; Balsters, Joshua H.; Coulon, Olivier; Fan, Lingzhong; Goulas, Alexandros; Hadj-Bouziane, Fadila; Hecht, Erin E.; Heuer, Katja; Jiang, Tianzi; Latzman, Robert D.; Liu, Xiaojin; Loh, Kep Kee; Patil, Kaustubh R.; Lopez-Persem, Alizée; Procyk, Emmanuel; Sallet, Jérôme; Toro, Roberto; Vickery, Sam; Weis, Susanne; Wilson, Charles Reagan; Xu, Ting; Zerbi, Valerio; Eickoff, Simon B.; Margulies, Daniel S.; Mars, Rogier B.; Schotten, Michel Thiebaut de

doi:10.1016/j.neuroimage.2020.117685

Cited by 60 publications

(48 citation statements)

References 161 publications

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“…whole or regional brain size measures of brain organization) (Mars et al, 2014). The ability to acquire data from whole brains opens up the possibility of elucidating principles of neural diversity across larger orders of mammalian species (Friedrich et al, 2021), and create between-species mappings to formally identify homologies and quantify unique aspects of any given brain (Mars et al, 2018). This also allows one to improve translational neuroscience by better understanding the relationship between the human brain and that of model species (e.g.…”

Section: Resultsmentioning

confidence: 99%

The Digital Brain Bank, an open access platform for post-mortem datasets

Tendler

Hanayik

Ansorge

et al. 2021

Preprint

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Post-mortem MRI provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy, and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), an interactive data discovery and release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes - Digital Neuroanatomist: data for neuroanatomical investigations; Digital Brain Zoo: data for comparative neuroanatomy; Digital Pathologist: data for neuropathology investigations. The first Digital Brain Bank release includes fourteen distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in seven non-human primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. Taken together, the Digital Brain Bank provides a cross-scale, cross-species investigation framework facilitating the incorporation of post-mortem data into neuroimaging studies.

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Section: Resultsmentioning

confidence: 99%

The Digital Brain Bank, an open access platform for post-mortem datasets

Tendler

Hanayik

Ansorge

et al. 2021

Preprint

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“…However, the same studies have also reported region-specific divergences revealing human-specific features potentially related to human-specific disorders. Consequently, comparing brain organization between humans and non-human primates can elucidate differentiation in brain organization potentially rooted in the process of species evolution and enrich our understanding of specializations in human brain organization ( de Schotten et al., 2019 ; Rilling, 2014 ; Van den Heuvel et al., 2016 ) [also see: Friedrich (2021) in this issue].…”

Section: Introductionmentioning

confidence: 99%

Functional parcellation of human and macaque striatum reveals human-specific connectivity in the dorsal caudate

et al. 2021

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A wide homology between human and macaque striatum is often assumed as in both the striatum is involved in cognition, emotion and executive functions. However, differences in functional and structural organization between human and macaque striatum may reveal evolutionary divergence and shed light on human vulnerability to neuropsychiatric diseases. For instance, dopaminergic dysfunction of the human striatum is considered to be a pathophysiological underpinning of different disorders, such as Parkinson's disease (PD) and schizophrenia (SCZ). Previous investigations have found a wide similarity in structural connectivity of the striatum between human and macaque, leaving the cross-species comparison of its functional organization unknown. In this study, resting-state functional connectivity (RSFC) derived striatal parcels were compared based on their homologous cortico-striatal connectivity. The goal here was to identify striatal parcels whose connectivity is human-specific compared to macaque parcels. Functional parcellation revealed that the human striatum was split into dorsal, dorsomedial, and rostral caudate and ventral, central, and caudal putamen, while the macaque striatum was divided into dorsal, and rostral caudate and rostral, and caudal putamen. Cross-species comparison indicated dissimilar cortico-striatal RSFC of the topographically similar dorsal caudate. We probed clinical relevance of the striatal clusters by examining differences in their cortico-striatal RSFC and gray matter (GM) volume between patients (with PD and SCZ) and healthy controls. We found abnormal RSFC not only between dorsal caudate, but also between rostral caudate, ventral, central and caudal putamen and widespread cortical regions for both PD and SCZ patients. Also, we observed significant structural atrophy in rostral caudate, ventral and central putamen for both PD and SCZ while atrophy in the dorsal caudate was specific to PD. Taken together, our cross-species comparative results revealed shared and human-specific RSFC of different striatal clusters reinforcing the complex organization and function of the striatum. In addition, we provided a testable hypothesis that abnormalities in a region with human-specific connectivity, i.e., dorsal caudate, might be associated with neuropsychiatric disorders.

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“…The purported advantages of having an asymmetrical brain have been widely discussed (Levy, 1974;Vallortigara & Rogers, 2020). We believe that developments in comparative neuroanatomy and comparative neuroimaging (Friedrich et al, 2021) will help shed light on the emergence of brain lateralization and thereby determine its significance for our own species.…”

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confidence: 93%

Where next for laterality research? Looking back and looking forward

Beaton

Richards

2021

Laterality

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While paying attention to the recommendations of Ocklenburg, Berretz, Packheiser, and Friedrich (2020) in the target article, researchers in the field of laterality should attempt to: (1) solve the long-standing puzzle of the relationship between handedness and language lateralization; (2) further explore the genetic bases of manual and cerebral asymmetry and of their associations with psychiatric and neurodevelopmental conditions; (3) explore the adaptive significance of laterality for humans and non-humans and elucidate the relationships of asymmetry across species; and (4) embrace developing technologies to investigate the interaction between the hemispheres during the performance of everyday tasks.

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Imaging evolution of the primate brain: the next frontier?

Cited by 60 publications

References 161 publications

The Digital Brain Bank, an open access platform for post-mortem datasets

The Digital Brain Bank, an open access platform for post-mortem datasets

Functional parcellation of human and macaque striatum reveals human-specific connectivity in the dorsal caudate

Where next for laterality research? Looking back and looking forward

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