Imaging features of atypical bleeds in young patients with hemophilia

Gavrel, M.; Rafowicz, Anne; d’Oiron, Roseline; Franchi‐Abella, Stéphanie; Lambert, Thierry; Adamsbaum, C.

doi:10.1016/j.diii.2018.11.010

Cited by 8 publications

(3 citation statements)

References 52 publications

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“…It can provide evidence of HA at an early stage or the occurrence of small structural degeneration. MRI score has also become a good, new method to monitor subtle HA lesions by imaging technology [ 16 , 17 ] MRI not only has high tissue resolution, but also can detect synovial hyperplasia and hemosiderin deposition in pathological joints, and can clearly show the early abnormal degeneration of cartilage [ 18 ]. In this work, MRI based on the Canny algorithm was used to compare it with conventional MRI.…”

Section: Discussionmentioning

confidence: 99%

Artificial Intelligence Algorithm‐Based Magnetic Resonance Imaging to Evaluate the Effect of Radiation Synovectomy for Hemophilic Arthropathy

Zhang

Duan

Xiao

et al. 2022

Contrast Media & Molecular Imaging

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This study aimed to discuss magnetic resonance imaging (MRI) based on artificial intelligence (AI) algorithm to evaluate the effect of radiation synovectomy for hemophilic arthropathy (HA). MRI based on the Canny algorithm was applied and compared with conventional MRI to evaluate its application effects according to the PSNR and SSIM. Sixty patients diagnosed with HA were selected as the research subjects. According to the detection method, the patients were divided into group A (pathological detection after radiation synovectomy), group B (conventional MRI detection), and group C (MRI detection based on the Canny algorithm). The application value of MRI based on the Canny algorithm was judged by comparing the differences between the two detection methods and pathological results. The results displayed that the reconstruction effect of the Canny algorithm was remarkably better than that of the traditional algorithm regarding the peak signal-to-noise ratio (PSNR) and structural similarity (SSIM), which showed a clearer synovial contour. The results of the IPSG score of joint effusion and hemorrhage showed that there was a difference in the detection rate of joints between conventional MRI and pathological results on the score of 1 and 2 ( P < 0.05 ); and there was no significant difference between the MRI and pathological results based on the Canny algorithm ( P > 0.05 ). The results of the IPSG score of synovial hyperplasia showed that the detection rate of conventional MRI was different from pathological results on the score of 1 and 2 ( P < 0.05 ); and there was no significant difference between the MRI and pathological results based on the Canny algorithm ( P > 0.05 ). The results of the IPSG score of hemosiderin deposition showed that the detection rate of conventional MRI was different from the pathological results on the score of 1 and 2 ( P < 0.05 ); and there was no significant difference between the MRI and pathological results based on the Canny algorithm ( P > 0.05 ). The synovial volume of patients after surgery was reduced compared with that before surgery. One-factor variance was used to analyze the clinical hemorrhage frequency before and after surgery, and the results showed that the differences were statistically significant ( P < 0.05 ). Therefore, MRI on account of AI algorithm made it easier to detect synovial contour, which was helpful to evaluate the efficacy of polygenic risk scores (PRS) surgery in HA patients. MRI based on the Canny algorithm had less differences between the score of hemophilic arthropathy and pathological results, which could replace conventional MRI examination and have clinical application value.

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Section: Discussionmentioning

confidence: 99%

Artificial Intelligence Algorithm‐Based Magnetic Resonance Imaging to Evaluate the Effect of Radiation Synovectomy for Hemophilic Arthropathy

Zhang

Duan

Xiao

et al. 2022

Contrast Media & Molecular Imaging

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“…CT abdomen and pelvis is the gold standard for initial evaluation of IDH. [1][2][3] It has largely replaced plain abdominal radiographs and upper gastrointestinal series due to its ability to rapidly identify complications such as intestinal obstruction, bowel perforation, and obstructive pancreatitis.…”

Section: F I G U R Ementioning

confidence: 99%

Conservative management of duodenal haematoma in a patient with severe haemophilia: A case report and literature review

Shipp

Munnikhuysen

et al. 2020

Haemophilia

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“…Abdominal haemophilic pseudotumours share the same entity but are extremely rare and may cause severe bleeding despite factor replacement and due to the dilatability of the abdominal cavity. Additionally, they may reach a size that compromises the function of abdominal organs [7][8][9][10][11]. However, the rarity of abdominal haemophilic pseudotumours prevents a clear treatment consensus.…”

Section: Introductionmentioning

confidence: 99%

Management of abdominal pseudotumours in haemophilia: a systematic review

Von Stauffenberg,

Hegemann,

Schwotzer

et al. 2023

Swiss Med Wkly

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AIM: Haemophilic pseudotumours are complications in patients with haemophilia A or B and result from locally repetitive bleeding, mainly in the musculoskeletal system. Abdominal haemophilic pseudotumours are exceptionally rare but may cause severe complications. This systematic review aimed to evaluate therapy strategies for symptomatic abdominal haemophilic pseudotumours. METHODS: We systematically searched three databases (Medline [PubMed], Web of Science and EMBASE) for publications published between 1995 and 2023. Two reviewers independently selected the studies, extracted data and performed a quality assessment using the JBI critical appraisal checklist. RESULTS: From a total of 1199 articles, 39 articles describing 41 cases were included for final analysis. Conservative or interventional treatment was performed in 12 cases. In eight cases, a step-up to surgical therapy after interventional treatment was indicated. Primary surgical therapy was performed in 21 cases. Failure to cure was documented in 50% (n = 6) of patients treated in the first group, with a mortality rate of 16.6% (n = 2). Interventional therapy with a step-up to surgery showed no morbidity or mortality. Primary surgical resection documented favourable results in 66.6% (n = 14), with failure to cure in 9.5% (n = 2) and a mortality rate of 14.3% (n = 3). CONCLUSION: Primary surgical resection can be a first-line therapy for symptomatic, abdominal haemophilic pseudotumours, whereas preoperative embolisation could be used as a bridging therapy before surgery, especially in emergency settings. Diagnostic biopsy and percutaneous drainage should be avoided to prevent complications.

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Imaging features of atypical bleeds in young patients with hemophilia

Cited by 8 publications

References 52 publications

Artificial Intelligence Algorithm‐Based Magnetic Resonance Imaging to Evaluate the Effect of Radiation Synovectomy for Hemophilic Arthropathy

Artificial Intelligence Algorithm‐Based Magnetic Resonance Imaging to Evaluate the Effect of Radiation Synovectomy for Hemophilic Arthropathy

Conservative management of duodenal haematoma in a patient with severe haemophilia: A case report and literature review

Management of abdominal pseudotumours in haemophilia: a systematic review

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