Imaging features of chondromyxoid fibroma: report of 15 cases and literature review

Cappelle, Sarah; Pans, Steven; Sciot, Raf

doi:10.1259/bjr.20160088

Cited by 37 publications

(22 citation statements)

References 28 publications

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“…Chondromyxoidfibrome (CMF) sind mit weniger als 1 % aller primären Knochentumoren sehr seltene gutartige chondrogene Tumoren [56]. Sie bestehen aus 3 Gewebeanteilen: 1. einer fibrösen Matrix in der Peripherie sowie 2. einer myxoiden und 3. einer chondroiden Matrix im Zentrum.…”

Section: Chondromyxoidfibromunclassified

Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Engel

Herget

Füllgraf

et al. 2020

Rofo

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Background Chondrogenic tumors are the most frequent primary bone tumors. Malignant chondrogenic tumors represent about one quarter of malignant bone tumors. Benign chondrogenic bone tumors are frequent incidental findings at imaging. Radiological parameters may be helpful for identification, characterization, and differential diagnosis. Methods Systematic PubMed literature research. Identification and review of studies analyzing and describing imaging characteristics of chondrogenic bone tumors. Results and conclusions The 2020 World Health Organization (WHO) classification system differentiates between benign, intermediate (locally aggressive or rarely metastasizing), and malignant chondrogenic tumors. On imaging, typical findings of differentiated chondrogenic tumors are lobulated patterns with a high signal on T2-weighted magnetic resonance imaging (MRI) and ring- and arc-like calcifications on conventional radiography and computed tomography (CT). Depending on the entity, the prevalence of this chondrogenic pattern differs. While high grade tumors may be identified due to aggressive imaging patterns, the differentiation between benign and intermediate grade chondrogenic tumors is challenging, even in an interdisciplinary approach. Key Points: Citation Format

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Section: Chondromyxoidfibromunclassified

Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Engel

Herget

Füllgraf

et al. 2020

Rofo

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“…It sometimes could be misdiagnosed as CMF, which is considered as an intermediate tumor with a much better prognosis. The majority of CMFs show radiological features of benign bony lesions consisting of internally lobulated to lobulated translucent osteolytic defects with scalloped and sclerotic margins [13]. In contrast, CMF-OSs may display radiographic features suggesting malignancy.…”

Section: Radiological Characteristicsmentioning

confidence: 99%

Chondromyxoid fibroma-like osteosarcoma: a case series and literature review

Zhong

Geng

et al. 2020

BMC Musculoskelet Disord

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Background: Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is an exceedingly rare subtype of low-grade central osteosarcoma (LGCO), accounting for up to 10% of cases and making it difficult to diagnose. CMF-OS is frequently misdiagnosed on a radiological examination and biopsy, even after the initial operation. Its treatment is a controversial issue due to its low-grade classification and actual high-grade behavior. Case presentation: We retrospectively reviewed the medical charts of more than 2000 osteosarcoma patients between 2008 and 2019; 11 patients with CMF-OS were identified, of which six patients were treated by our institution with complete clinical characteristics, including treatment and prognosis, radiological and pathological features were reviewed. Three males and three females with a median age of 46 (range 22-56) years were pathologically proven to have CMF-OS. The radiological presentation of CMF-OS is variable, thus radiological misdiagnoses are common. However, one must not ignore a malignant radiologic appearance. The most distinctive pathological feature conferring the diagnosis of CMF-OS is the presence of osteoid production directly by the tumor cells under a chondromyxoid fibroma (CMF)-like background. Differential diagnoses based on comprehensive data from CMF, LGCO, chondrosarcoma (CHS), conventional osteosarcoma (COS), etc., are needed. All patients were treated with an operation and chemotherapy, and one patient received additional radiotherapy. Nevertheless, recurrence and metastasis are common in CMF-OS patients. Relatively invasive biological behavior of CMF-OS is against the low-grade classification of this disease. Conclusions: It is important to recognize CMF-OS and distinguish it from CMF, CHS, COS and other LGCOs. CMF-OS has a relatively poor prognosis despite its low-grade classification.

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“…On gadoliniumenhanced T1-weighted imaging, there is a peripheral nodular enhancement (69%) or a diffuse contrast enhancement (31%), with homogeneous or heterogeneous patterns (Kim et al). 55 More recently, another pattern of enhancement was described, a linear peripheral enhancement with foci of low SI centrally in 50% in a study by Cappelle et al 54 The presence of a periosteal reaction (13-57%), bone marrow edema (38-63%), and soft tissue edema (20-73%) on MRI were also described. Cortical erosions and sclerotic border can also be well depicted on MRI.…”

Section: Chondromyxoid Fibromamentioning

confidence: 97%

“…Chondromyxoid fibroma (CMF) is a very rare benign cartilage bone tumor, representing < 1% of all primary bone tumors. 2,53,54 Pathologically, it consists of myxoid, chondroid, and fibrous tissue. CMF has a wide age distribution, with a peak incidence in the second decade of life and another peak incidence around the fifth to seventh decade.…”

Section: Chondromyxoid Fibromamentioning

confidence: 99%

“…In the latter, CMF are prone to occur at rarer localizations. 54 Furthermore, due to reduced resistance of the pediatric thin bone cortices and medullary spongiosa, CMF might be more aggressive in younger ages, and age at diagnosis also might be correlated with increased recurrence rates, with increased recurrence in patients < 15 years of age. 53 A CMF most often arises within the medullary cavity.…”

Section: Chondromyxoid Fibromamentioning

confidence: 99%

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Chondroid Tumors as Incidental Findings and Differential Diagnosis between Enchondromas and Low-grade Chondrosarcomas

Afonso

Isaac

Martel

2019

Semin Musculoskelet Radiol

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Chondroid tumors are a heterogeneous group of neoplasms that all share the production of chondroid matrix. This ranges from a fetal type to mature hyaline cartilage and mirrors its imaging characteristics.The benign chondroid tumors represent some of the most encountered incidental bone lesions, with osteochondroma the most frequent benign bone tumor. Enchondroma is mostly asymptomatic, and yet it is probably the second most common primary bone tumor. Similarly, its malignant counterpart, chondrosarcoma, is the second most common malignant primary bone tumor.The 2013 World Health Organization (WHO) updated this group of tumors, and grade 1 chondrosarcoma was renamed “atypical cartilage tumor” and classified as an intermediate type of tumor, not a malignancy, which better describes its clinical behavior.In this article we summarize changes made in the updated 2013 WHO classification and highlight the diagnostic features differentiating an enchondroma from a low-grade chondrosarcoma. We also describe practical imaging aspects of the remaining chondroid tumors.

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Imaging features of chondromyxoid fibroma: report of 15 cases and literature review

Cited by 37 publications

References 28 publications

Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Chondromyxoid fibroma-like osteosarcoma: a case series and literature review

Chondroid Tumors as Incidental Findings and Differential Diagnosis between Enchondromas and Low-grade Chondrosarcomas

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