Imaging features of Ewing's sarcoma

Patnaik, Sujata; Yarlagadda, Jyostnarani; Rammurti, S.

doi:10.4103/jcrt.jcrt_1350_16

Cited by 30 publications

(33 citation statements)

References 9 publications

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“…Ewing Sarcoma (ES) was first described by James Ewing in 1921 (2,6). It is a small round blue neoplastic cells (1,2,3,4,5,6,7,8,9) with clear to lightly eosinophilic cytoplasm, evenly dispersed chromatin, and indistinct nucleoli (3,7). ES is found in bones or in the surrounding soft tissues (1,3,4,5,6,7,8).…”

Section: Discussionmentioning

confidence: 99%

“…It is a small round blue neoplastic cells (1,2,3,4,5,6,7,8,9) with clear to lightly eosinophilic cytoplasm, evenly dispersed chromatin, and indistinct nucleoli (3,7). ES is found in bones or in the surrounding soft tissues (1,3,4,5,6,7,8). ES is usually diagnosed in the second decade of life (1,3,4,5,7,8,10), the occurrence in adulthood is sporadic (1,6,3,8).…”

Section: Discussionmentioning

confidence: 99%

“…ES is found in bones or in the surrounding soft tissues (1,3,4,5,6,7,8). ES is usually diagnosed in the second decade of life (1,3,4,5,7,8,10), the occurrence in adulthood is sporadic (1,6,3,8). Ewing's sarcoma present 4% of paediatric malignant tumours (4), It arises mostly in the long bones in 47% of cases, pelvis in 19%, and on ribs in 12% of cases (7), vertebral location is seen in less than 6% of cases (4,8), and mostly located in sacrococcygeal region (5,6,7), its presence on nonsacral spine is found in only 0.9% of all cases (7) with extremely rare involvement of the cervical spine (5,7).…”

Section: Discussionmentioning

confidence: 99%

“…The clinic is summarized in the triad of local pain, palpable mass and neurologic deficit depending on the site of compression (1,7). Radiographic exams in spinal ES are not specific (3,6,8). Mostly it is a lytic lesion, sclerotic changes are rarely seen (7,8,9) especially in primary lesions (8).…”

Section: Discussionmentioning

confidence: 99%

“…Ewing's sarcoma is a bony highly malignant tumour, it occurs most frequently in the second decade of life (1,3,4,5,7,8,10). Ewing's sarcoma is a rare affection (4), located usually in the pelvis, the femur, the humerus, the ribs, the mandible and clavicle (7), other location are rare especially in the spine (4,8). We report three cases of spinal Ewing's sarcoma two primary spine locations and one on young adult with unusual clinical presentation.…”

Section: Introductionmentioning

confidence: 99%

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Ewing’s sarcoma of the mobile spine

Khelifa¹,

Aliyu²,

Bachir³

et al. 2019

roneuro

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Background. Ewing’s sarcoma is a bony highly malignant tumour, it occurs most frequently in the second decade of life. Ewing’s sarcoma is a rare affection, located usually in the pelvis, the femur, the humerus, the ribs, the mandible and clavicle, other location are rare especially in the spine. We report three cases of spinal Ewing’s sarcoma, two primary spine locations and one on young adult with unusual clinical presentation. Cases presentation Case 1. The first patient is a girl of 14 years old without past medical history. She presented initially two months before consultation a neck pain followed days after by a weakness of the left upper limb; the spine imaging performed objectified a destructive process of C2 with a spinal cord compression. The patient was operated beneficiating of a spinal cord decompression and a subtotal removal of the tumour. The pathologist’s results were in favour of Ewing’s sarcoma and the patient was oriented to oncology. Case 2. The second patient is a man of 31 years old operated five years before he consulted for shoulder Ewing’s sarcoma followed by chemotherapy and radiotherapy, he presented two months before consultation a cauda equina syndrome. Spine MRI objectified a double location of an epidural tumour at T3-T4 and S1-S2 levels. The patient was operated beneficiating of subtotal removal of the tumour. The laboratory exam results were in favour of Ewing’s sarcoma and the patient was oriented to oncology. Case 3. The third patient is a 6 years old boy who presented a 1 month history of low back pain followed by a rapidly deteriorating weakness of both lower limbs over a weak. On examination there was bilateral spastic paraplegia, hypoesthesia below the level of Th10 and a urinary retention. The MRI imaging revealed a lesion on the levels Th8, Th9 and Th10 vertebras involving the body, pedicle, lamina, and the transverse process on the left side with an epidural invasion compressing the spinal cord. The tumour was radically removed. Pathology report was in favour of Ewing’s sarcoma. Two weeks after surgery the patient was able to walk. He was referred for adjuvant systemic chemotherapy. Conclusion. Ewing’s sarcoma is rare malignant tumour. The location in the spine exposes the patient to more complications because of the neurostructures compression. The surgical total removal followed by radio and chemotherapy is the only option with the best prognostic and guaranties an acceptable life quality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ewing’s sarcoma of the mobile spine

Khelifa¹,

Aliyu²,

Bachir³

et al. 2019

roneuro

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Incidence of skeletal‐related events in patients with Ewing sarcoma: An observational retrospective study in Japan

Aiba,

Kojima,

Shimoi

et al. 2024

Cancer Medicine

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BackgroundSkeletal‐related events (SREs), including the pathological fracture, surgical treatment or radiation of bone lesions, malignant spinal cord compression, hypercalcemia, are important considerations when managing metastatic bone tumors; however, owing to their rarity, the incidence of SREs in patients with Ewing sarcoma remains unknown.MethodsWe retrospectively reviewed the clinical data from 146 patients with Ewing sarcoma treated at a single institution from 2005 to 2019. The median age at diagnosis was 22.7 years. Fifty patients (34.2%) had metastatic disease at diagnosis. The primary outcome was the SRE‐free rate among patients with Ewing sarcoma. Moreover, we identified the risk factors for SREs using univariate or multivariate analyses.ResultsDuring the observational period (median, 2.6 years), SREs occurred in 23 patients. Radiation to the bone, malignant spinal cord compression, and hypercalcemia were documented as the initial SREs in 12 patients (52.2%), 10 patients (43.5%), and one patient (4.3%), respectively. The SRE‐free rate was 94.2 ± 2.0, 87.3 ± 3.0, and 79.6 ± 3.8% at 1, 2, and 3 years after the initial visit, respectively. Multivariate analysis revealed bone metastasis at diagnosis (hazard ratio [HR] = 4.41, p = 0.007), bone marrow invasion (HR = 34.08, p < 0.001), and local progression or recurrence after definitive treatment (HR = 3.98, p = 0.012) as independent risk factors for SREs.ConclusionsSREs are non‐rare events that can occur during the treatment course for Ewing sarcoma, with an especially high incidence of malignant spinal cord compression. Patients with metastatic disease at diagnosis, especially in the bone or bone marrow, or with local progression or recurrence after definitive treatment, should be carefully monitored for the occurrence of SREs. The most effective methods to monitor the occurrence of SREs and new preventative therapies for SREs should be investigated in the future.

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Retroperitoneal Ewing's sarcoma in a woman with advanced breast cancer delineated by contrast‐enhanced ultrasound: A case report

Luo,

Mo,

Zhu

et al. 2023

Sonography

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Extraosseous Ewing's sarcoma is a malignant mesenchymal tumor much rarer than skeletal Ewing's sarcoma. The synchronous or metachronous occurrence of advanced breast cancer with retroperitoneal Ewing's sarcoma is extremely rare. To date, only a few cases of extraosseous Ewing's sarcoma with contrast‐enhanced ultrasound findings have been reported. This study aims to report a case of a retroperitoneal Ewing's sarcoma in a 39‐year‐old woman with advanced breast cancer, where grayscale ultrasound, contrast‐enhanced ultrasound, and computed tomography findings were included. To our knowledge, this is the first reported case of ultrasound and contrast‐enhanced ultrasonography manifestation of retroperitoneal Ewing's sarcoma as a second primary tumor.

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Imaging features of Ewing's sarcoma

Cited by 30 publications

References 9 publications

Ewing’s sarcoma of the mobile spine

Ewing’s sarcoma of the mobile spine

Incidence of skeletal‐related events in patients with Ewing sarcoma: An observational retrospective study in Japan

Retroperitoneal Ewing's sarcoma in a woman with advanced breast cancer delineated by contrast‐enhanced ultrasound: A case report

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