Thisarticle discusses various aspects of pediatric lymphadenopathy, focusing on Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). It outlines common etiologies, diagnostic techniques, and key characteristics of differ- ent lymphoma subtypes. HL is classified into classical HL (CHL) and nodular lymphocytic predominant HL (NLPHL), while NHL includes Burkitt lymphoma (BL), lymphoblastic lymphoma (LBL), diffuse large B-cell lymphoma (DLBCL), and anaplastic large cell lymphoma (ALCL). The text emphasizes the importance of accurate diagnosis through various tests, including imaging modalities such as positron emission tomography (PET) and computed tomography (CT). It also discusses the potential use of ctDNA as a prognostic marker and highlights genetic alterations contributing to lymphoma development. The relevance of these findings for pediatric patients and their impact on treatment strategies is emphasized throughout the text.