Imaging features of sporadic breast cancer in women under 40 years old: 97 cases

Bullier, B; MacGrogan, Gaëtan; Bonnefoi, Hervé; Hurtevent-Labrot, G.; Lhomme, Édouard; Brouste, Véronique; Boisserie-Lacroix, M.

doi:10.1007/s00330-013-2966-z

Cited by 37 publications

(51 citation statements)

References 30 publications

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“…In many countries, asymptomatic women under 40 years of age are usually not recommended for mammographic breast cancer screening due to the possible hazards of regular exposure to radiation and cost-benefit issues related to having dense breast tissue (18). Furthermore, the Ko- (8) 11 (14) 1 (3) showed calcifications when including the mass with calcification, and this was consistent with a previous report (20).…”

Section: Discussionsupporting

confidence: 80%

Clinicopathological and Imaging Features of Breast Cancer in Korean Women under 40 Years of Age

Kim

Jang

Kim

et al. 2017

J Korean Soc Radiol

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Purpose:To evaluate the clinicopathological and imaging features of mammography, ultrasonography, and magnetic resonance imaging (MRI) for breast cancer in Korean women under 40 years of age according to molecular subtypes. Materials and Methods:We included 183 breast cancers in 176 consecutive women under 40 years old who had been diagnosed with breast cancer between January 2012 and November 2014. The patients' clinical and pathologic records were available as electronic medical records. A retrospective review of the pre-operative imaging studies was performed with 177 mammographies, 183 ultrasonographies, and 178 MRIs. Results: Eighty-six percent (158/183) of lesions were symptomatic, with masses (147/183) as the most common presentation. Eighty percent (22/25) of the asymptomatic lesions were diagnosed via screening ultrasonography. The luminal A subtype was the most common (n = 79, 43%), human epidermal growth factor receptor 2-enriched subtype showed indistinct margins on mammography (p = 0.006), the triple negative subtype depicted a posterior enhancement on ultrasonography (p < 0.001) and rim enhancement on MRI (p < 0.001). Conclusion: Breast cancers in Korean women under 40 years of age are commonly presented with a palpable mass, and luminal A is the most common molecular subtype. In our study, the imaging and pathologic characteristics of breast cancer in younger women were similar to those previously reported for older patients.

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Section: Discussionsupporting

confidence: 80%

Clinicopathological and Imaging Features of Breast Cancer in Korean Women under 40 Years of Age

Kim

Jang

Kim

et al. 2017

J Korean Soc Radiol

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“…In our study, the positive predictive value of mammography for diagnosis was 80.5%, which is within the previously reported range (50-90%) [17,18]. The reason for all the false-negative cases was that extremely dense parenchyma obscured the lesion (breast tissue composition, d).…”

Section: Discussionsupporting

confidence: 75%

“…The revised BI-RADS provides uniform terminology in the lexicon across all three imaging modalities: mammography, ultrasound (US), and magnetic resonance imaging (MRI) [16]. There have been several reports on the radiological features of breast cancer in young women with different age cut-offs [17][18][19], but most studies did not use the revised BI-RADS.…”

Section: Introductionmentioning

confidence: 99%

Breast cancer in very young women (<30 years): Correlation of imaging features with clinicopathological features and immunohistochemical subtypes

Kim

Kang

et al. 2015

European Journal of Radiology

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“…Despite there was no statistically significant difference in the imaging findings of molecular subtypes, we observed that the presence of calcifications at mammography was more common in HER2 subtype and oval/round mass at ultrasound was more common in triple-negative subtype, which was also described in previous studies [18,19].…”

Section: Discussionsupporting

confidence: 72%

Breast cancer diagnosed before the 40 years: imaging findings and correlation with histology and molecular subtype

et al. 2017

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Background: To evaluate the imaging findings in patients with breast cancer diagnosed before age 40 and their correlation with histological type and molecular subtype. Methods: A descriptive, retrospective, single-center study was conducted by reviewing imaging exams and medical records, after approval of the institution's Ethics Review Board. Among the 120 patients studied, 112 (93.3%) had mammography, 113 (94.2%) underwent ultrasonography and 105 (87.5%) underwent breast magnetic resonance imaging (MRI). Histopathology data was performed in most cases after surgical resection, which was available for 113 patients (94.2%). Results: The mean age at diagnosis of primary breast cancer was 34 years. Most patients had no family history of breast cancer or ovarian cancer (60.7%), and were symptomatic at diagnosis (75.6%). The most common histological type was no-special type (NST) invasive carcinoma (73.8%). Regarding the molecular subtype, luminal B was the most common (42.6%), followed by triple negative (20.2%). The malignant tumor was identified in 92.9% of patients who underwent mammography, 96.5% of patients submitted to ultrasound and 98% of those who performed MRI. MRI was superior to other methods in the evaluation of multifocal and multicentric lesions. There was no statistically significant association between imaging findings and molecular subtypes in the present study. Conclusions: This study demonstrated that imaging methods play a fundamental role in the characterization of cases of breast cancer diagnosed in patients younger than 40 years. Despite the ultrasound has been the most widely used method, we found improved characterization of breast lesions when also used mammography and MRI.

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Imaging features of sporadic breast cancer in women under 40 years old: 97 cases

Abstract: The imaging characteristics of cancers in patients under 40 years without proven gene mutations do not differ from their older counterparts, but appear correlated to phenotypic profiles, which have a different distribution in young women compared to the general population.

Cited by 37 publications

References 30 publications

Clinicopathological and Imaging Features of Breast Cancer in Korean Women under 40 Years of Age

Clinicopathological and Imaging Features of Breast Cancer in Korean Women under 40 Years of Age

Breast cancer in very young women (<30 years): Correlation of imaging features with clinicopathological features and immunohistochemical subtypes

Breast cancer diagnosed before the 40 years: imaging findings and correlation with histology and molecular subtype

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