Imaging features of ultrasound and contrast-enhanced ultrasound in primary hepatic carcinosarcoma: three cases report

Liu, Chunrui; Wei, Shuping; Wu, Min; Kong, Wencheng

doi:10.11152/mu-2002

Cited by 4 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contrast-enhanced ultrasound detects a thicker ring-enhancing part of the abscess than that of PLSC patients, 39 peripheral nodular enhancement of PLSC, and hypervascularization of HCC in the arterial phase. 31 , 40 However, these differences are minor and difficult to practice, so difficulties in diagnoses should always be considered.…”

Section: Discussionmentioning

confidence: 99%

“…For patients suffering from advanced PLSC at initial diagnosis and with recurrence after surgery, the prognosis is worse, with a median OS of less than 6 months. 43 Cytotoxicity drugs and sorafenib 44,45 have been used for treatments, including gemcitabine combined with paclitaxel, 35 gemcitabine combined with cisplatin, 40 and pirarubicin combined with cisplatin, 46 but only in case reports. Epirubicin combined with cisplatin (Case 4) and docetaxel combined with cisplatin (Case 9) have been used in two of our cases, but unplanned terminations made it impossible to provide information about the treatment-related prognoses.…”

Section: Dovepressmentioning

confidence: 99%

See 1 more Smart Citation

Primary Liver Sarcomatoid Carcinoma: A Case Series and Literature Review

Xing

et al. 2021

JHC

View full text Add to dashboard Cite

Background: Primary liver sarcomatoid carcinoma (PLSC) is rare. To improve the understanding of PLSC, cases were described and reviewing the literature. Methods: A retrospective analysis was performed on 14 cases of PLSC diagnosed by pathology in Northeastern China from 2010 to 2020. An individual participant data analysis based on reported cases was conducted to determine epidemiological characteristics, clinical characteristics, and prognoses of PLSC. Results: A total of 136 cases involved our 14 cases and 122 cases from previous reports. The percentages of sarcomatoid hepatocellular carcinoma, sarcomatoid cholangiolocellular carcinoma, and mixed and unclassified types were 36.8%, 41.9%, 5.9%, and 15.4%, respectively. A total of 95.6% PLSC was found in Asia. There was a lower percentage of hepatitisinfected patients in Japan, when compared with the Republic of Korea (38.5% vs 70.0%, P<0.05). Five cases were initially misdiagnosed as a hepatic abscess by imaging. A total of 36.7% cases had metastases when being diagnosed, and 68.9% cases relapsed during the follow-up. The median disease-free survival and overall survival (OS) were 3 months and 5 months, respectively. Only radical surgery (hazard ratio = 0.308, 95% confidence interval 0.186-0.512, P<0.001) indicated a better OS. Conclusion: PLSC was more prevalent in Asia and there were possibilities of misdiagnoses. Surgery is still an effective treatment and can significantly prolong the OS. Only limited strategies for recurrent or advanced PLSC, immunotherapy may be possible treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Dovepressmentioning

confidence: 99%

Primary Liver Sarcomatoid Carcinoma: A Case Series and Literature Review

Xing

et al. 2021

JHC

View full text Add to dashboard Cite

show abstract

“…The prognosis of HCS cases is often worse than that of conventional liver neoplasms, which may be attributed to the aggressive sarcomatous elements with their extensive differentiation [11] . A study from Japan analyzed 21 reported cases of primary HCS and found that the survival time of patients who received surgery and postoperative comprehensive treatment was signi cantly longer than that of patients who did not undergo surgery, with a survival time for the former group of up to 30 months [12,13] . Surgical resection appears to be the most effective treatment for HCS.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Rupture as the Initial Symptom of Primary Hepatic Carcinosarcoma: A Thorough Case Report with Follow-up Data and Literature Review

Zhao,

Wang,

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Primary hepatic carcinosarcoma (HCS) is an extremely rare malignant tumor that is composed of a mixture of carcinomatous and sarcomatous elements. However, there have been few reported cases, especially with sufficient records to describe imaging and pathological features, posing the diagnosis, treatment, and prognosis of HCS significant challenges for clinical physicians. Here, we report and review a case of HCS, including combined imaging findings, analysis of pathology and immunohistochemistry, and clinical features, which will be beneficial for future diagnosis, improving clinical management, and exploring effective treatments to improve survival for HCS patients. Case presentation: Here, we report a case of HCS with spontaneous rupture as the initial symptom in a 77-year-old elderly male who was admitted with right upper abdominal pain for 8 days. The computed tomography (CT) enhancement scan revealed a massive, enhanced shadow primarily outside of the liver; hypodense fluid was seen around the liver, which was initially considered a spontaneous rupture of giant primary liver cancer. The patient underwent a laparotomy, but postoperative pathology unexpectedly showed an HCS with spontaneous rupture. Although the primary lesion was successfully removed during the surgery, the tumor recurred only 5 months after surgery and was approximately as large as the initial tumor. Unfortunately, the patient was not a candidate to undergo surgery to remove the recurrent tumor. Just 9 days after his second discharge, the patient passed away at home. His postoperative survival time was only 5 months. Conclusions HCS is an extremely rare malignant tumor with high malignancy and poor prognosis, for which there is still no effective therapy. This study demonstrates the imaging characteristics and pathological results of an HCS patient whose initial symptom was a spontaneous rupture hemorrhage and reviews the clinical features of HCS previously reported in the literature. Additional similar cases are needed to clarify the exact diagnosis, and treatment of this disease.

show abstract

“…In the retrospective literature, 24 articles 2,3,[7][8][9][10][11]13,14,17,[19][20][21][22][23][24][26][27][28][29][30][31][32][33] were involved in the imaging manifestations, including our study of total of 35 patients. Due to the different proportion of carcinomatous components and sarcomatous components in HCS, and their pathological types were not the same, the imaging manifestations were different.…”

Section: Discussionmentioning

confidence: 99%

<p>The Clinicopathological and Imaging Characteristics of Primary Hepatic Carcinosarcoma and a Review of the Literature</p>

Bin

Chen

Peng

et al. 2020

JHC

View full text Add to dashboard Cite

Purpose: To improve the understanding of hepatic carcinosarcoma (HCS) by analyzing radiological imaging data and clinicopathological features. Materials and Methods: A retrospective analysis was performed on four patients with HCS confirmed immunohistochemically. The analysis included three males and one female, aged 29 to 64 years. Four patients underwent computed tomography (CT) scans, and one underwent magnetic resonance imaging (MRI) scans simultaneously. Results: Three patients had a history of hepatitis B, cirrhosis or fibrosis, and two patients had schistosomiasis. Two cases tested positive for elevated serum carbohydrate antigen (CA) 19-9. The maximum diameters of the lesions ranged from 7.8 to 9.0cm. Pathologically, the carcinomatous and sarcomatous elements in two patients could not be classified, one of the patients had cholangiocellular carcinoma (CCC) and undifferentiated sarcoma, the other had hepatocellular carcinoma (HCC) and undifferentiated pleomorphic sarcoma (UPS). All tumors showed heterogeneous density/intensity, accompanied by vast cystic changes and necrosis, with two cases having cystic septations. Capsule formation was not identified. The margins of the radiological images showed irregular ring enhancement. One case presented continuous progressive enhancement, one case with "fast in fast washout" and two cases with "fast in late washout". Lymphonodus metastasis, satellite nodules, vascular embolism, and organ invasion (hepatic flexure of the colon) were identified. Conclusion: HCS is a rare, high-grade malignancy with poor prognosis. The preoperative diagnosis is expected to improve by carefully analyzing the imaging features of the patients in combination with their clinical characteristics. Radical resection and postoperative chemoradiotherapy can improve the survival rate of patients.

show abstract

Imaging features of ultrasound and contrast-enhanced ultrasound in primary hepatic carcinosarcoma: three cases report

Cited by 4 publications

References 11 publications

Primary Liver Sarcomatoid Carcinoma: A Case Series and Literature Review

Primary Liver Sarcomatoid Carcinoma: A Case Series and Literature Review

Spontaneous Rupture as the Initial Symptom of Primary Hepatic Carcinosarcoma: A Thorough Case Report with Follow-up Data and Literature Review

<p>The Clinicopathological and Imaging Characteristics of Primary Hepatic Carcinosarcoma and a Review of the Literature</p>

Contact Info

Product

Resources

About