Imaging Findings of Invasive Micropapillary Carcinoma of the Breast

Yun, Se Un; Choi, Bomi; Shu, Kwang Sun; Kim, Sang Woo; Seo, Yongwon; Lee, Jinsun; Chang, Euijin

doi:10.4048/jbc.2012.15.1.57

Cited by 28 publications

(38 citation statements)

References 20 publications

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“…Even though the imaging characteristics of IMPC are not distinguishable from that of IDC-NOS, positron emission tomography-computed tomography might be helpful in the diagnosis by identifying the high maximum standardized uptake value, which is apparent as a feature of IMPC because of its frequent LVI and LNM. 11 Most patients with IMPC present with axillary LNM at initial diagnosis, and LNM is the most important prognosis predictor of IMPC. Chen et al 9 identified LNM in 84.8% (84 of 99) of the IMPC cases, significantly higher than that in 50% (50 of 100; P , .001) in IDC-NOS cases.…”

Section: Clinical Featuresmentioning

confidence: 99%

Invasive Micropapillary Carcinoma of the Breast: An Update

Yang¹,

Liu²,

Zhang³

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

107

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Context.-Invasive micropapillary carcinoma (IMPC) is a distinct variant of mammary carcinoma in which tumor cells are arranged in morulelike clusters devoid of fibrovascular cores and situated within empty stromal spaces. Identification of IMPC can be achieved by the assessment of morphologic features in conjunction with the characteristic ''inside-out'' staining pattern of epithelial membrane antigen and sialyl Lewis X highlighted by immunohistochemical analysis. Although recognizing micropapillary architecture is often not challenging, the criteria for distinguishing between mixed and pure IMPC remain imprecise. Some mucin-producing carcinomas can also have micropapillary histology, but there is no consensus on whether these tumors are variants of IMPC or mucinous carcinomas. The molecular genetic studies demonstrate that IMPCs have distinct molecular genetic profiles, supporting the theory that they constitute distinct pathologic entities. However, genomic analyses have not identified any specific genomic aberration that may explain the distinctive morphology and clinical behavior of IMPC.Objective.-To provide an overview on the current concepts in the diagnosis and pathogenesis of IMPC of the breast, incorporating recent molecular genetic advances and prognosis-based reclassification.Data Sources.-PubMed search and the cited references were reviewed.Conclusions.-The recent evolution of prognosis-based reclassification and molecular genetic advances has enhanced our knowledge of the pathogenesis of IMPC of the breast. Additional studies might reveal consistent molecular alterations that underlie the formation of the inside-out growth pattern, and they might elucidate the molecular mechanisms responsible for the unfavorable clinical behavior of IMPC.

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Section: Clinical Featuresmentioning

confidence: 99%

Invasive Micropapillary Carcinoma of the Breast: An Update

Yang¹,

Liu²,

Zhang³

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

107

View full text Add to dashboard Cite

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“…However, in the literature, no consensus has been reached regarding the amount of IMPC tissue in the breast carcinoma required to make a diagnosis and determine the type of IMPC ( 5 ). IMPC is associated with a high incidence of axillary lymph node metastases and local recurrence and poor clinical outcome ( 6 ). These clinical characteristics indicate the significance of IMPC being recognised by surgeons and pathologists.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological features of invasive micropapillary carcinoma of the breast

Cui¹,

Feng²,

Zhao³

2014

Oncology Letters

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The aim of the present study was to evaluate the clinical and immunohistopathological findings of invasive micropapillary carcinoma (IMPC) of the breast. In total, 25 patients were included in the present study, all of whom were diagnosed with IMPC. The mammography and ultrasound scanning (US) findings were analysed retrospectively according to the American College of Radiology Breast Imaging Reporting and Data System lexicon. Surgical specimens obtained from the patients were microscopically reviewed in consensus by two pathologists with a specialisation in breast pathology. All the patients presented with palpable lumps in the breast, a high-density irregular mass associated with microcalcifications revealed by mammography and an irregular hypoechoic mass with a spiculated margin revealed by US. Axillary lymph node metastases were identified in 80% of the patients. Immunohistochemical studies revealed the lesions to be highly positive for the oestrogen receptor (ER) and c-erbB-2 (88% and 84%, respectively). Although no significant imaging characteristics were found to distinguish IMPC from typical invasive ductal carcinoma, IMPC resulted in nodal metastases and was highly positive for ER and c-erbB-2. This clinical significance indicates the significance of this entity being recognised by pathologists and surgeons.

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“…Although this carcinoma is rare, it is clinically significant because of the high frequency of lymphovascular invasion, axillary nodal metastasis, and locoregional recurrence, as well as the poor prognosis [ 13 ]. It has been reported that mammographic, ultrasonographic, and magnetic resonance imaging findings of invasive micropapillary carcinoma are highly suggestive of malignancy and no feature to distinguish invasive micropapillary carcinoma from typical invasive ductal carcinoma has yet been described [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Invasive Micropapillary Carcinoma in Axillary Ectopic Breast and Synchronous Ductal Carcinoma In Situ in the Contralateral Breast

Lim

Lee

et al. 2017

J Breast Cancer

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The development of ectopic breast tissue is attributable to the failure of primitive mammary tissue to regress after the development of the mammary ridge, except at pectoral breast sites, and is most often evident in the axillae. Several benign and malignant breast diseases have been reported in ectopic axillary breast tissues. The most common cancerous pathology of ectopic breast tissue is invasive ductal carcinoma. Ectopic breast cancer presenting with simultaneous primary cancer of the pectoral breast is extremely rare. Herein, we report an invasive micropapillary carcinoma of an axillary ectopic breast, combined with a synchronous ductal carcinoma in situ in the contralateral pectoral breast of a 61-year-old woman.

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Imaging Findings of Invasive Micropapillary Carcinoma of the Breast

Cited by 28 publications

References 20 publications

Invasive Micropapillary Carcinoma of the Breast: An Update

Invasive Micropapillary Carcinoma of the Breast: An Update

Clinicopathological features of invasive micropapillary carcinoma of the breast

Invasive Micropapillary Carcinoma in Axillary Ectopic Breast and Synchronous Ductal Carcinoma In Situ in the Contralateral Breast

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