Imaging findings of the spinal peripheral Ewing's sarcoma family of tumours

Huang, Weiyuan; Tan, Weihan; Geng, Dao Ying; Zhang, J.; Wu, Guangyao; Zhang, B.-Y.; Li, Y.-X.; Yin, Bo

doi:10.1016/j.crad.2013.09.010

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…10,11 Those originating from the soft tissue or bone occur in older patients with an average age of 28 years. 10,12 The mean age of onset in our group was slightly lower, but most likely not significant because of the small sample size. The clinical manifestations of the patients showed varying degrees of headache, dizziness and vomiting, which were most likely due to elevated intracranial pressure caused by oedema and mass effect.…”

Section: Discussionmentioning

confidence: 57%

“…This is consistent with reports that pPNET can spread along the spinal nerves or the neighbouring tissue, causing bone and soft tissue destruction. 12,[14][15][16] However, the fact that the lesions and brain tissue boundaries were clear might be due to the meninges and blood-brain barrier that played a role in infringing the tumour of the brain.…”

Section: Discussionmentioning

confidence: 99%

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The imaging features of meningeal Ewing sarcoma/peripheral primitive neuroectodermal tumours (pPNETs)

Zhao¹,

Liu²,

Liu³

et al. 2014

BJR

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Objective: To explore the imaging features of meningeal Ewing sarcoma/peripheral primitive neuroectodermal tumours (pPNETs). Methods: The imaging features and pathological characteristics of eight cases of surgically and pathologically confirmed Ewing sarcoma/pPNET were analysed retrospectively in light of recent literature on the disease. Results: The peak age was between 10 and 20 years. The lesions tended to be spindle shaped and dural based, usually widely so. CT showed that the lesions had slightly uneven high density in five cases and iso-low mixed density in three cases; marked heterogeneous enhancement was seen in all cases after contrast injection. MRI of the lesions showed varying proportions of isointense and hypointense signal in all cases on unenhanced T 1 weighted imaging and varying proportions of isointense and hyperintense signal on T 2 weighted imaging. After contrast injection, marked heterogeneous enhancement was seen in all cases; three cases showed a short and nodular dural tail and five cases showed adjacent skull erosion and osteolysis. Pathological results included high cell density, haemorrhage and necrosis. The cells resembled lymphocytes and spindle cells with transparent cytoplasm. CD99 and vimentin were expressed by all tumour cells. Conclusion: Features of meningeal Ewing sarcoma/ pPNETs include peak incidence at 10-20 years of age, a broad connection to the meninges, a thick dural tail involved with tumour, skull and scalp erosion and early metastasis. Necrosis and cystic changes are the common histological findings. Advances in knowledge: The imaging features of meningeal Ewing sarcoma/pPNETs have not been reported. The study helps to identify meningeal Ewing sarcoma/ pPNETs and meningioma.Ewing sarcoma/peripheral primitive neuroectodermal tumours (pPNETs) are a group of highly malignant small round cell neoplasms, which include Ewing sarcoma, Askin tumour and pPNET. 1 We collected eight cases of meningeal Ewing sarcoma/pPNET confirmed by pathology and immunohistochemistry to review the imaging and pathological findings in order to deepen our understanding and improve the diagnosis of this disease, and to provide more accurate clinical information. METHODS AND MATERIALSEight cases of meningeal Ewing sarcoma/pPNET were confirmed by surgery and pathology in the Second Hospital of Lanzhou University, Lanzhou, China, between November 2005 and December 2011. There were five males and three females aged between 7 and 23 years (mean age, 15 years). Presenting symptoms had been of 2 weeks to 18 months of duration. There were four cases presenting with headache, two cases with headache, dizziness and vomiting and two cases presenting with fever. One case had right proptosis, accompanied by visual disturbances. Two cases were accompanied by physical disabilities. Two cases had non-tender masses. Pre-operative imaging diagnoses were meningioma in four cases, metastatic tumour in one case, hemangiopericytoma in one case and skull osteosarcoma in one case.MRI scans were performed with a 1.0-T...

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

The imaging features of meningeal Ewing sarcoma/peripheral primitive neuroectodermal tumours (pPNETs)

Zhao¹,

Liu²,

Liu³

et al. 2014

BJR

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“… 6 ES is thought to arise from neural crest cells. 7 MRI 8 plays a predominant role in evaluating the features of the lesion and developing a preoperative surgical plan for the ES family of tumors. The signal intensity of spinal peripheral ES is usually homogeneous and is enhanced homogeneously after the administration of contrast agents.…”

Section: Discussionmentioning

confidence: 99%

Revision Surgical Treatment of a Second Lumbar Ewing Sarcoma

et al. 2015

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We report a case of a 58-year-old man who presented initially with lumbar pain.According to radiography, computed tomography, magnetic resonance imaging, and bone biopsy results, Ewing sarcoma (ES) was diagnosed. Tumor resection was performed, followed by chemotherapy and radiotherapy; pathology confirmed the diagnosis of ES. After surgery, the tumor recurred twice with progressive symptoms, meriting repeated excisional surgery. At the 4-year follow-up, the patient showed apparent improvement, with return of function and strength and resolution of pain.We discuss its clinical features and treatment in the light of the current knowledge.

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“…The extraosseous component is typically larger than the intraosseous lesions and invasion into the paraspinal area and spinal cord is common (Figure 7). After the administration of gadolinium mild to moderate enhancement is observed [114].…”

Section: Primary Tumoursmentioning

confidence: 99%

Sacral Tumours on MRI: A Pictorial Essay

Vanheule

Huysse

Herregods

et al. 2019

Journal of the Belgian Society of Radiology

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Tumours of the sacrum can be primary or secondary. Since the sacrum is rich in haematopoietic bone marrow, bone metastases are the most frequent aetiologies. However, tumours can arise from all components of the sacrum and primary bone tumours should be considered in case of a solitary lesion and absence of oncologic history. As the clinical signs are usually non-specific, magnetic resonance imaging has become an indispensable tool in narrowing the differential diagnosis and determining the therapeutic approach. This pictorial essay illustrates specific features of the most common sacral tumours on magnetic resonance (MR) imaging.

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Imaging findings of the spinal peripheral Ewing's sarcoma family of tumours

Cited by 8 publications

References 24 publications

The imaging features of meningeal Ewing sarcoma/peripheral primitive neuroectodermal tumours (pPNETs)

The imaging features of meningeal Ewing sarcoma/peripheral primitive neuroectodermal tumours (pPNETs)

Revision Surgical Treatment of a Second Lumbar Ewing Sarcoma

Sacral Tumours on MRI: A Pictorial Essay

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