Imaging for the diagnosis and response assessment of renal tumours

Rossi, Sabrina; Prezzi, Davide; Kelly-Morland, Christian; Goh, Vicky

doi:10.1007/s00345-018-2342-3

Cited by 73 publications

(53 citation statements)

References 104 publications

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“…22 The principal role of CT scan is as adjunct to ultrasound in assessing the nature of a renal mass. 23 When obesity or overlying gas precludes imaging of the kidney by ultrasound, CT can then be used. CT scanning is also useful in confirming presence and extent of a renal mass.…”

Section: Discussionmentioning

confidence: 99%

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Role of computed tomography scan in diagnosis of retroperitoneal masses

Patel

2020

Int Surg J

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Background: In the vast and ever-expanding field of surgery there are only few subjects which have provoked controversy; curiosity related to correct management of patients suffering from various condition of the abdomen. This becomes very true when the patient has a retroperitoneal mass clinically. The problem of retroperitoneal mass was intriguing, fascinating and certainly most perplexing. The present study was planned with the objective to study the various clinical presentations of retroperitoneal mass, and their radiological findings, and co-relation between these various findings.Methods: This was a prospective, cross-sectional study. The study included 30 patients clinically diagnosed having retroperitoneal mass, attending the department of general surgery.Results: The most common affected age group was of 40-50 years (9, 30.00%). The most frequent presenting symptoms were abdominal lump (28, 93.33%). Pallor was the commonest clinical sign (20, 66.67%). Retroperitoneal lymph node masses were the commonest (12, 40.00%) malignant lesions. Retroperitoneal lymphadenopathy was the most common lesion.Conclusions: The retroperitoneum has long been an area poorly visualised by conventional radiographic techniques and in this respect, computed tomography scan has great advantages over other modalities. Hence the modern surgeon should no longer be considered a ‘shadow-gazer' but an anatomist in-vivo.

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Section: Discussionmentioning

confidence: 99%

“…CT scanning is also useful in confirming presence and extent of a renal mass. 23 CT is acknowledged to be superior to IV urography and ultrasound for diagnosis and evaluation of renal masses. 24 The limitation here is the fact that it is not possible to tell malignant from benign masses.…”

Section: Discussionmentioning

confidence: 99%

Role of computed tomography scan in diagnosis of retroperitoneal masses

Patel

2020

Int Surg J

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“…The pace of basic, translational and clinical RCC research development is rapid. We have selected, as outlined below, those topics where we felt that we must improve our knowledge and understanding to provide improved prevention, diagnostic and treatment strategies to our patients.With the widespread use of modern cross-sectional abdominal imaging, the incidence of asymptomatic renal tumours has been increasing, especially in patients over the age of 70 [1,2]. Many of these incidentalomas do not have and will not develop adverse pathological or clinical features meaning any intervention may not change the natural history of the disease.…”

mentioning

confidence: 99%

“…With the widespread use of modern cross-sectional abdominal imaging, the incidence of asymptomatic renal tumours has been increasing, especially in patients over the age of 70 [1,2]. Many of these incidentalomas do not have and will not develop adverse pathological or clinical features meaning any intervention may not change the natural history of the disease.…”

mentioning

confidence: 99%

“…Many of these incidentalomas do not have and will not develop adverse pathological or clinical features meaning any intervention may not change the natural history of the disease. Unfortunately, while imaging is an essential part of the workup, precise criteria to determine the biology of a renal tumour are lacking [2]. However, this "opportunistic", unspecific screening by non-urological specialities has decreased the number of patients presenting with advanced RCC [1], which results from a shift to an earlier stage where RCC is curable or does not cause harm if left alone.…”

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confidence: 99%

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Renal cell carcinoma: standards and controversies

Klatte

Stewart

2018

World J Urol

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The purpose of this topic issue of the World Journal of Urology is to relay novel developments and controversies in renal cell carcinoma (RCC). To achieve this, we have selected renowned experts to review various scientific and clinical aspects of RCC . The pace of basic, translational and clinical RCC research development is rapid. We have selected, as outlined below, those topics where we felt that we must improve our knowledge and understanding to provide improved prevention, diagnostic and treatment strategies to our patients.With the widespread use of modern cross-sectional abdominal imaging, the incidence of asymptomatic renal tumours has been increasing, especially in patients over the age of 70 [1,2]. Many of these incidentalomas do not have and will not develop adverse pathological or clinical features meaning any intervention may not change the natural history of the disease. Unfortunately, while imaging is an essential part of the workup, precise criteria to determine the biology of a renal tumour are lacking [2]. However, this "opportunistic", unspecific screening by non-urological specialities has decreased the number of patients presenting with advanced RCC [1], which results from a shift to an earlier stage where RCC is curable or does not cause harm if left alone. "Smart" ultrasound-based screening of a target population defined by established risk factors (age, sex, body mass index, smoking history) and promising plasma markers such as kidney injury molecule-1 [3] may be even more beneficial. Such a strategy may increase the incidence of the disease but would hopefully further decrease mortality rates. If we utilise renal tumour biopsy and active surveillance wisely, intervention rates will remain on a similar level. Overtreatment of screendetected tumours must be avoided at all costs.Research into the biology and the genetic basis of RCC has led to a greater understanding of molecular pathways, refinements in pathological classification, development of drugs and new prognostic factors. The trunk-branch model of key genetic events and heterogeneity is now generally accepted, with many of these events occurring years to decades before tumours become clinically evident [4]. Many more landmark studies will be published from the TRAC-ERx Renal Consortium and other initiatives in the foreseeable future. The review article in this topic issue includes a summary of recent evidence, but also a methodological overview and a glossary of terms used to describe genetic changes [4]. We hope that this will serve as a comprehensive up-to-date resource for urologists, specifically for those not involved in genomic research. Similarly, the review on the most recent WHO classification, staging and grading of renal tumours by Warren and Harrison [5] outlines standards and controversies from the perspective of pathologists. It remains important to look beyond our own immediate specialty to provide high-quality care.Despite several efforts with adjuvant phase III trials in high-risk non-metastatic RCC, a clinically s...

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Magnetic resonance imaging vs. computed tomography image concordance for linear measurements and the quantification of abdominal skeletal muscle

Medline

Nabavizadeh

et al. 2022

JCSM Clinical Reports

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BackgroundLinear measurement analysis using computed tomography (CT) scans to quantify abdominal muscle mass has been validated as a clinically practical approach for screening individuals with low muscle mass. However, there is still a need to validate such analysis using magnetic resonance imaging (MRI) imaging. The aim of this study is to assess the reproducibility and concordance of CT and MRI imaging for linear measurement analyses of skeletal muscle at mid‐L3.MethodsWe retrospectively analysed 66 patients with available CT and MRI images within 30 days of one other to evaluate linear measurement CT and MRI concordance. Linear measurement analysis for abdominal/pelvic CT and MRI scans for eight patients was conducted independently three times by the same person separated by at least 1 week to assess intra‐rater variability. The intra‐observer variability for both CT and MRI was assessed using the intraclass correlation coefficient (ICC). The concordance and correlation of CT and MRI mid‐L3 for linear measurements were assessed using Pearson correlation coefficients and Bland–Altman plots.ResultsThe intra‐rater reliability of linear measurements for both CT and MRI was high, as measured by the ICC (CT range: 0.788–0.992; MRI range: 0.766–0.984). CT and MRI linear measurements were found to be significantly positively correlated for all psoas (total psoas r = 0.98; P < 0.0001) and paraspinal muscle measurements (total paraspinal r = 0.99; P < 0.0001). Bland–Altman analysis revealed a mean bias of 0.83 (range: 0.03–5.56) for MRI over CT linear measurements.ConclusionsCT and MRI images were shown to be concordant for linear measurement analysis of abdominal muscle mass. T2‐weighted MRI sequences can be used interchangeably with CT in the assessment of sarcopenia using linear measurement analysis.

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Imaging for the diagnosis and response assessment of renal tumours

Abstract: The diagnosis and characterisation of SRM and response assessment following targeted therapy for advanced RCC are key challenges which warrant further research.

Cited by 73 publications

References 104 publications

Role of computed tomography scan in diagnosis of retroperitoneal masses

Role of computed tomography scan in diagnosis of retroperitoneal masses

Renal cell carcinoma: standards and controversies

Magnetic resonance imaging vs. computed tomography image concordance for linear measurements and the quantification of abdominal skeletal muscle

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