Imaging how attention modulates pain in humans using functional MRI

Bantick, Susanna; Wise, Richard G.; Ploghaus, Alexander; Clare, Stuart; Smith, Stephen M.; Tracey, Irene

doi:10.1093/brain/awf022

Cited by 766 publications

(589 citation statements)

References 47 publications

Supporting

Mentioning

541

Contrasting

Unclassified

Order By: Relevance

“…More extensive areas of cingulate cortex have been reported for pain-related contrasts but are clearly not of sufficient consistency across studies to survive empirical scrutiny. A notable example is perigenual cingulate activity, which is reported more frequently for contrasts that include upregulated or downregulated pain states [Bantick et al, 2002;Lorenz et al, 2002]. The discrete locale of the ALE cingulate clusters may have important implications for cingulotomy as a treatment for intractable pain.…”

Section: Discussionmentioning

confidence: 99%

Brain activity associated with painfully hot stimuli applied to the upper limb: A meta‐analysis

Farrell

Laird

Egan

2005

Human Brain Mapping

116

View full text Add to dashboard Cite

Abstract:The capacity of pain to alert against potential injury or focus attention on damaged tissue is enhanced by the intrinsically aversive nature of the experience. Finding methods to relieve pain will ultimately be facilitated by deeper understanding of the processes that contribute to the experience, and functional brain imaging has contributed substantially toward that end. An impressive body of literature has identified a distributed network of pain-related activity in the brain that is subject to considerable modulation by different stimulus parameters, contextual factors, and clinical conditions. The fundamental substrates of the pain network are yet to be distilled from the highly variable results of studies published thus far. Qualitative reviews of the pain-imaging literature have been contributory, but lack the greater surety of quantitative methods. We employ the activation likelihood estimation (ALE) meta-analytic technique to establish the most consistent activations among studies reporting brain responses subsequent to the application of noxious heat. A network of pain-related activity was replicated for stimuli to either upper limb that included two discernible regions of the mid-anterior cingulate cortex, bilateral thalami, insula, and opercula cortices, posterior parietal cortex, premotor cortex, supplementary motor area, and cerebellum. The findings of the meta-analysis resonate with other streams of information that continue to enhance our understanding of pain in the brain. The results also point toward new areas of research that may be fruitful for the exploration of central pain processing. Hum Brain Mapp 25:129 -139, 2005.

show abstract

Section: Discussionmentioning

confidence: 99%

Brain activity associated with painfully hot stimuli applied to the upper limb: A meta‐analysis

Farrell

Laird

Egan

2005

Human Brain Mapping

116

View full text Add to dashboard Cite

show abstract

“…While participants in the control condition of Study 1 imagined their hand, to assess the influence of the specific contents of imagery rather than the process of imagery, participants in the control condition of Study 2 did nothing, to assess the effects of the mere passage of time (natural history), and to thereby allow for a comparison that is more representative of clinical practice. An additional reason for using a different control condition in Study 2, was that we were concerned that the image used in the control condition of Study 1 might also affect pain; merely imagining one's hand, which was previously immersed in the cold water, might reduce pain via mindfulness‐like processes (Reiner et al., 2013), or might alternatively increase pain by enhancing awareness of the pain (Bantick et al., 2002). Secondary, we aimed to assess whether the effects of response imagery on pain could be enhanced by adding a verbal suggestion.…”

Section: Studymentioning

confidence: 99%

Placebo‐like analgesia via response imagery

Peerdeman

Laarhoven

Bartels

et al. 2017

European Journal of Pain

View full text Add to dashboard Cite

BackgroundPlacebo effects on pain are reliably observed in the literature. A core mechanism of these effects is response expectancies. Response expectancies can be formed by instructions, prior experiences and observation of others. Whether mental imagery of a response can also induce placebo‐like expectancy effects on pain has not yet been studied systematically.MethodsIn Study 1, 80 healthy participants were randomly allocated to (i) response imagery or (ii) control imagery. In Study 2, 135 healthy participants were randomly allocated to (i) response imagery with a verbal suggestion regarding its effectiveness, (ii) response imagery only, or (iii) no intervention. In both studies, expected and experienced pain during cold pressor tests were measured pre‐ and post‐intervention, along with psychological and physiological measures.ResultsParticipants rated pain as less intense after response imagery than after control imagery in Study 1 (p = 0.044, ηp2 = 0.054) and as less intense after response imagery (with or without verbal suggestion) than after no imagery in Study 2 (p < 0.001, ηp2 = 0.154). Adding a verbal suggestion did not affect pain (p = 0.068, ηp2 = 0.038). The effects of response imagery on experienced pain were mediated by expected pain.ConclusionsThus, in line with research on placebo effects, the current findings indicate that response imagery can induce analgesia, via its effects on response expectancies.SignificanceThe reported studies extend research on placebo effects by demonstrating that mental imagery of reduced pain can induce placebo‐like expectancy effects on pain.

show abstract

“…Several of the 75 experiments were eliminated as they included data acquired on non-Stroop tasks such as the Flanker task and the Simon task [Derbyshire et al, 1998;Fan et al, 2003;Peterson et al, 2002]. This restriction also eliminated variations of the Stroop task such as the emotional Stroop [Isenberg et al, 1999;George et al, 1994;Whalen et al, 1998], the counting Stroop [Bantick et al, 2002;Bush et al, 1998], and other variations of the Stroop task [de Zubicaray et al, 2001;Milham et al, 2003]. Subject groups were limited to normal subjects [Milham et al, 2002;Yucel et al, 2002].…”

Section: Selection Of Conditions and Contrastsmentioning

confidence: 99%

A comparison of label‐based review and ALE meta‐analysis in the Stroop task

Laird

McMillan²,

Lancaster

et al. 2005

Human Brain Mapping

309

264

View full text Add to dashboard Cite

Meta-analysis is an important tool for interpreting results of functional neuroimaging studies and is highly influential in predicting and testing new outcomes. Although traditional label-based review can be used to search for agreement across multiple studies, a new functionlocation meta-analysis technique called activation likelihood estimation (ALE) offers great improvements over conventional methods. In ALE, reported foci are modeled as Gaussian functions and pooled to create a statistical whole-brain image. ALE meta-analysis and the label-based review were used to investigate the Stroop task in normal subjects, a paradigm known for its effect of producing conflict and response inhibition due to subjects' tendency to perform word reading as opposed to color naming. Both methods yielded similar activation patterns that were dominated by response in the anterior cingulate and the inferior frontal gyrus. ALE showed greater involvement of the anterior cingulate as compared to that in the label-based technique; however, this was likely due to the increased spatial level of distinction allowed with the ALE method. With ALE, further analysis of the anterior cingulate revealed evidence for somatotopic mapping within the rostral and caudal cingulate zones, an issue that has been the source of some conflict in previous reviews of the anterior cingulate cortex. Hum Brain Mapp 25:6 -21, 2005.

show abstract

Imaging how attention modulates pain in humans using functional MRI

Cited by 766 publications

References 47 publications

Brain activity associated with painfully hot stimuli applied to the upper limb: A meta‐analysis

Brain activity associated with painfully hot stimuli applied to the upper limb: A meta‐analysis

Placebo‐like analgesia via response imagery

A comparison of label‐based review and ALE meta‐analysis in the Stroop task

Contact Info

Product

Resources

About