Imaging in Renal Cell Carcinoma

Krajewski, Katherine M.; Giardino, Angela; Zukotynski, Katherine; Abbeele, Annick D. Van den; Pedrosa, Iván

doi:10.1016/j.hoc.2011.04.005

Cited by 22 publications

(8 citation statements)

References 104 publications

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“…Therapy of metastatic RCC with TKIs can be monitored with non-invasive imaging methods to analyze therapy success as well as predict patient outcomes [ 22 , 23 ]. Several preclinical and clinical studies have been carried out to analyze therapeutic effects of a TKI such as sunitinib or sorafenib utilizing PET [ 31 - 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…As a clinical tool, PET can be helpful in the diagnosis, outcome prediction, and therapy monitoring of RCC cancer patients [ 22 ]. Its broader clinical utilization in this context is, however, subject to discussion [ 23 ]. Several PET radiotracers for the imaging of tumor hypoxia have been developed, such as the 2-nitroimidazoles [ 18 F]FMISO, [ 18 F]FAZA, [ 18 F]EF5, and the copper-64-based thiosemicarbazone [ 64 Cu]ATSM [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Detecting functional changes with [18F]FAZA in a renal cell carcinoma mouse model following sunitinib therapy

Chapman

Jans

et al. 2014

EJNMMI Res

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BackgroundThe multitargeting tyrosine kinase inhibitor (TKI) sunitinib is currently the first-line drug therapy for metastasizing renal cell carcinoma (RCC). TKIs have profound effects on tumor angiogenesis, leading to modifications of the tumor microenvironment. The goal of this study was to determine whether these treatment-induced changes can be detected with [18F]FAZA.MethodsThe present study utilized positron emission tomography (PET) to analyze tumor oxygenation status during and after sunitinib therapy in the murine Caki-1 RCC tumor model. Dynamic and static scans were performed, as well as ex vivo biodistributions at 3 h post injection (p.i.). Immunohistochemical analysis of tumor tissue was carried out for the quantification of pimonidazole binding and the hypoxia-associated factors CD-31, Ki-67, and Von Willebrand factor (VWF). In addition, in vitro cellular uptake studies were done to analyze the direct effects of sunitinib on the Caki-1 cells.ResultsDuring therapy with sunitinib (40 mg/kg/day), uptake of [18F]FAZA into Caki-1 mice decreased by 46 ± 5% (n = 4; 5 days) at 3 h post injection (p.i.) during the first study and 22 ± 5% (n = 8; 9 days) during the long-term study, indicating a decrease in the tumor's hypoxia level. However, when drug therapy was stopped, this effect was reversed completely, and the tumor [18F]FAZA uptake increased to 126 ± 6% (n = 6) of the control tumor uptake, indicative of an even higher level of tumor hypoxia compared to the therapy starting point. Sunitinib had no direct effect on [18F]FAZA uptake into Caki-1 cells in vitro.Conclusion[18F]FAZA PET could be used to monitor drug response during sunitinib therapy in RCC and may guide combination therapies based on the tumor's hypoxia status.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detecting functional changes with [18F]FAZA in a renal cell carcinoma mouse model following sunitinib therapy

Chapman

Jans

et al. 2014

EJNMMI Res

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“…Approximately 10% of kidney cancers were incidental cancers in the early 1970s; however, with the development of various imaging technologies such as computer tomography and magnetic resonance imaging, this increased to approximately 60% in the 1990s [ 7 ]. Accordingly, the majority of kidney cancers are discovered incidentally while performing radiological tests for other purposes [ 11 ]. Compared with symptomatic tumors, incidental tumors are smaller, have favorable prognostic scores, and are less likely to metastasize [ 12 ].…”

Section: Resultsmentioning

confidence: 99%

Epidemiological evidences on overdiagnosis of prostate and kidney cancers in Korean

Bae¹

2015

Epidemiol Health

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OBJECTIVES:The prostate specific antigen test is widely used as the main method of screening prostate cancer in Korea. Additionally, the use of ultrasound sonography may lead to overdiagnosis of kidney cancer as well as thyroid cancer. This study aimed to highlight epidemiological evidences regarding overdiagnosis of prostate and kidney cancers in Korean.METHODS:The annual trends of national incidence and mortality of prostate and kidney cancers provided by the Korean Statistical Information Service were evaluated.RESULTS:The rate of increase in the incidence of prostate and kidney cancer was 6 and 5 times higher than that of mortality between 2000 and 2011, respectively. Additionally, the age group showing the highest incidence in prostate cancer shifted from 85 years and older to 75-79 years.CONCLUSIONS:This evidence suggests that prostate and kidney cancers are overdiagnosed in Korea. Further research in this area, using national cancer registry databases, should be encouraged to prevent overdiagnosis.

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“…In the current era, with the increasing proportion of incidentally found renal masses, a downward stage migration and concomitant increase in benign pathology has been well described [1, 26, 30]. Novel techniques using immunhistochemical or cytogenetics may better predict biological aggressiveness, which may help determine if treatment is even necessary [68]. An example of a promising investigation is radio-labeled antibodies against carbonic anhydrase-IX with positron emission tomography which has excellent positive and negative predictive values for clear cell phenotype [69].…”

Section: Novel Imagingmentioning

confidence: 99%

Advancements in Laparoscopic Partial Nephrectomy: Expanding the Feasibility of Nephron-Sparing

Pietzak

Guzzo

2012

Advances in Urology

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Partial nephrectomy (PN) offers equivalent oncologic outcomes to radical nephrectomy (RN) but has greater preservation of renal function and less risk of chronic kidney disease and cardiovascular disease. Laparoscopic PN remains underutilized likely because it is a technically challenging operation with higher rates of perioperative complications compared to open PN and laparoscopic RN. A review of the latest PN literature demonstrates that recent advancements in laparoscopic approaches, imaging modalities, ischemic mitigating strategies, renorrhaphy techniques, and hemostatic agents will likely allow greater utilization of LPN and expand its usage to increasingly more complex tumors.

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Imaging in Renal Cell Carcinoma

Cited by 22 publications

References 104 publications

Detecting functional changes with [18F]FAZA in a renal cell carcinoma mouse model following sunitinib therapy

Detecting functional changes with [18F]FAZA in a renal cell carcinoma mouse model following sunitinib therapy

Epidemiological evidences on overdiagnosis of prostate and kidney cancers in Korean

Advancements in Laparoscopic Partial Nephrectomy: Expanding the Feasibility of Nephron-Sparing

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