Imaging in tuberculosis

Skoura, Evangelia; Zumla, Alimuddin; Bomanji, Jamshed

doi:10.1016/j.ijid.2014.12.007

Cited by 243 publications

(204 citation statements)

References 64 publications

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“…The basic principle of PET/CT is based on the accumulation of FDG in areas of increased glucose metabolism. It has the ability to accumulate not only in malignant tissues but also in inflammatory cells such as neutrophils, activated macrophages, and lymphocytes at the site of inflammation or infections such as TB (27). Maximum standardized uptake values are not useful for differentiating LC from TB.…”

Section: Discussionmentioning

confidence: 99%

Is Tuberculosis a Challenge in the Management of Lung Cancer?

Köksal¹,

Kızılgöz²,

Özcan³

et al. 2017

Eurasian J Pulmonol

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Objective: The coincidence of tuberculosis (TB) and lung cancer (LC) at the initial diagnosis or the development of TB during the course of LC is a challenge in the management of both diseases. Herein we reviewed 10 LC patients who coincidentally had TB and evaluated the challenges in the management of both diseases. Methods:The files of patients were retrieved from an archive, and available study forms were completed. Results:The study included 10 LC and TB patients during a 4 year-period. The sites of TB were the lung (seven patients), mediastinal lymph nodes (LN) (one patient), cervical LN (one patient), and subcutaneous nodules (one patient). LC and TB were simultaneously diagnosed in four patients. The diagnosis of pulmonary TB was confirmed by sputum culture two months after LC diagnosis in four patients. TB was diagnosed later in the follow-up period in two patients. Only one patient with early-stage LC who had undergone surgical resection tolerated anti-TB therapy well. In one patient, TB caused the over-staging of LC. In one patient, LC had progressed during the course of anti-TB therapy. Hepatotoxicity was the leading adverse reaction due to anti-TB therapy. Conclusion:These patients highlighted the importance of considering TB in the course of LC, especially in countries with a high TB prevalence. TB may cause the advanced staging of LC at the initial diagnosis; chemotherapy may worsen the TB course or cause reactivation TB. Reactivation TB may be considered as the progression of LC without tissue diagnosis or sputum analysis. The tolerability of anti-TB therapy is poor in these patients.

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Section: Discussionmentioning

confidence: 99%

Is Tuberculosis a Challenge in the Management of Lung Cancer?

Köksal¹,

Kızılgöz²,

Özcan³

et al. 2017

Eurasian J Pulmonol

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“…Cavitation is the hallmark radiographic feature in postprimary TB, which results from reactivation of an inactive focus of pulmonary TB (13). Chest CT findings in adult patients with active pulmonary TB are related to the number of AFB on the sputum smear.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Cavitary Pulmonary Tuberculosis in Children

Lotfian

Mehrian

2016

Arch Pediatr Infect Dis

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Background: Cavitary pulmonary tuberculosis (TB) is rare in children. Objectives: The aim of this study was to evaluate the characteristics of cavitary pulmonary TB in children. Patients and Methods: This retrospective study was conducted on 97 children less than 15 years old with pulmonary TB to assess the clinical characteristics and radiographic findings of patients with cavitary lesions. Results: Seven (7%) out of 97 children had cavitary pulmonary TB. All patients were between 13 and 14 years old with a female/male ratio of 2.5/1. The most common symptom was cough. All patients had positive sputum smear results. Cavitary lesions were seen in the right upper lobe in six cases and multiple cavities were observed in two cases. Conclusions: This finding strongly suggests that older children with pulmonary TB can be more at risk than younger ages. Special attention must be paid to the prevention and treatment of TB in older children, particularly females.

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“…Diagnosis of pulmonary tuberculosis may be based on contrast enhanced computed tomography (CECT) of thorax which is said to be more sensitive than chest X-ray [51], positive smear for acid-fast bacillus in sputum sample, endobronchial lavage. The specimen obtained through endobronchial ultrasound (EBUS) or endoscopic ultrasound (EUS) may be subjected to microbiologocal and histopathological evaluation to confirm MTb.…”

Section: Diagnosismentioning

confidence: 99%

An Update on Tubercular Uveitis

Agarwal¹,

Shrivastav²

2017

J Clin Exp Ophthalmol

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Tuberculosis (TB) is an important cause of infectious uveitis causing significant morbidity and mortality especially in endemic countries. Mycobacterium tuberculosis (MTb) may infect any tissue or organ in the body, lungs being the most commonly affected. Ocular TB occurs due to hematogenous dissemination of MTb or due to a hypersensitivity reaction to the bacteria. It may lead to a very severe inflammation and destruction of ocular tissues leading to an irreversible loss of vision. Infection of the eye by MTb most commonly involves the uveal tissue causing anterior, intermediate, and posterior or panuveitis.Awareness of the varied clinical manifestations is important to suspect the ocular TB which may often be difficult to confirm by diagnostic tests available. A timely diagnosis and management may help in preventing severe loss of vision and the eye.

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Imaging in tuberculosis

Cited by 243 publications

References 64 publications

Is Tuberculosis a Challenge in the Management of Lung Cancer?

Is Tuberculosis a Challenge in the Management of Lung Cancer?

Assessment of Cavitary Pulmonary Tuberculosis in Children

An Update on Tubercular Uveitis

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