Imaging markers of intracranial aneurysm development: A systematic review

Kancheva, Angelina; Velthuis, Birgitta K.; Ruigrok, Ynte M.

doi:10.1016/j.neurad.2021.09.001

Cited by 10 publications

(5 citation statements)

References 50 publications

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“…The pathogenesis of AComA aneurysms is predominantly influenced by factors encompassing the bifurcation morphology, encompassing the angles and diameters of the involved vessels, and their intricate interplay with hemodynamic alterations that precipitate the initiation of aneurysm formation (İdil Soylu et al, 2019;Kancheva et al, 2022;López-Sala et al, 2020;Zhang et al, 2018). This convergence of structural and hemodynamic factors underscores the complexity underlying AComA-related aneurysm development, shedding light on a critical area of investigation in the pursuit of enhancing our understanding and management of cerebrovascular pathologies.…”

Section: Discussionmentioning

confidence: 99%

“…Only 22% patients with an AComA aneurysm that have a symmetrical diameter of A1 segment of the ACA. (Chen et al, 2020;Flores et al, 2013;İdil Soylu et al, 2019;Kancheva et al, 2022) Besides of the diameter size, the ACAs bifurcation has its own hemodynamic characteristic that on many studies has been mentioned as one of the relevant factors to the formation of aneurysm. The blood streams have directly hit the apex of the juction points of the ACAs and cause high pressure in this area.…”

Section: Methodsmentioning

confidence: 99%

“…It has been reported that the A1-A2 angle was significantly narrower (103 ± 20 degrees) in patients with an AComA aneurysm than those observed in patients without aneurysm. (İdil Soylu et al, 2019;Kancheva et al, 2022;Sadatomo et al, 2013;van Tuijl et al, 2022;Zhang et al, 2018)…”

Section: Methodsmentioning

confidence: 99%

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Imaging of the Anterior Communicating Artery: Normal and Abnormal Findings Related to Aneurysm

Abdulloh

2023

COMORBID

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The anterior communicating artery (AComA) is a critical component of the Circle of Willis, serving as a vital conduit that connects the bilateral anterior cerebral arteries. This study aims to provide a comprehensive overview of the imaging characteristics of the AComA, encompassing both normal variations and abnormal findings associated with aneurysm development. Utilizing advanced imaging techniques, a thorough analysis of the AComA complex was conducted in a cohort of subjects. Normal anatomical variants were meticulously documented, highlighting variations in length, diameter, and branching patterns. Abnormal findings indicative of potential aneurysm markers was carefully assessed, encompassing variations in morphology, hemodynamic flow patterns, and wall integrity. Special attention was given to elucidate the factors contributing to aneurysm initiation within the AComA complex. The clinical significance of distinguishing between normal anatomical variations and potential pathological findings was underscored, emphasizing the critical importance of early detection and intervention to mitigate the risks associated with aneurysm rupture. The findings of this study contribute valuable insights to the field of neurovascular diagnostics and therapeutic strategies. By enhancing our understanding of the AComA and its role in aneurysm development, this research aims to empower clinicians with the knowledge needed for informed decision-making and proactive management. Ultimately, the comprehensive examination of AComA imaging, encompassing both normal and abnormal variants, holds the potential to drive advancements in cerebrovascular care and improve patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Imaging of the Anterior Communicating Artery: Normal and Abnormal Findings Related to Aneurysm

Abdulloh

2023

COMORBID

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“…The pathogenesis of UIA development remains insufficiently understood. 3 Altered hemodynamics is one of the most widely accepted hypotheses contributing to aneurysmal development and growth, in which hemodynamic wall shear stress (WSS) contributes to pathophysiologic remodeling of the vessel wall. [4][5][6] Several studies related intra-aneurysmal hemodynamics to aneurysmal size and growth, in which the most established hemodynamic parameters associated with UIA were complex flows, concentrated areas of high WSS, or frictional forces.…”

mentioning

confidence: 99%

“…The pathogenesis of UIA development remains insufficiently understood 3 . Altered hemodynamics is one of the most widely accepted hypotheses contributing to aneurysmal development and growth, in which hemodynamic wall shear stress (WSS) contributes to pathophysiologic remodeling of the vessel wall 4–6 .…”

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confidence: 99%

Hemodynamic Parameters in the Parent Arteries of Unruptured Intracranial Aneurysms Depend on Aneurysm Size and Are Different Compared to Contralateral Arteries: A 7 Tesla 4D Flow MRI Study

Tuijl

Timmins

Velthuis

et al. 2023

Magnetic Resonance Imaging

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BackgroundDifferent Circle of Willis (CoW) variants have variable prevalences of aneurysm development, but the hemodynamic variation along the CoW and its relation to presence and size of unruptured intracranial aneurysms (UIAs) are not well known.PurposeGain insight into hemodynamic imaging markers of the CoW for UIA development by comparing these outcomes to the corresponding contralateral artery without an UIA using 4D flow magnetic resonance imaging (MRI).Study TypeRetrospective, cross‐sectional study.SubjectsThirty‐eight patients with an UIA, whereby 27 were women and a mean age of 62 years old.Field Strength/SequenceFour‐dimensional phase‐contrast (PC) MRI with a 3D time‐resolved velocity encoded gradient echo sequence at 7 T.AssessmentHemodynamic parameters (blood flow, velocity pulsatility index [vPI], mean velocity, distensibility, and wall shear stress [peak systolic (WSSMAX), and time‐averaged (WSSMEAN)]) in the parent artery of the UIA were compared to the corresponding contralateral artery without an UIA and were related to UIA size.Statistical TestsPaired t‐tests and Pearson Correlation tests. The threshold for statistical significance was P < 0.05 (two‐tailed).ResultsBlood flow, mean velocity, WSSMAX, and WSSMEAN were significantly higher, while vPI was lower, in the parent artery relative to contralateral artery. The WSSMAX of the parent artery significantly increased linearly while the WSSMEAN decreased linearly with increasing UIA size.ConclusionsHemodynamic parameters and WSS differ between parent vessels of UIAs and corresponding contralateral vessels. WSS correlates with UIA size, supporting a potential hemodynamic role in aneurysm pathology.Level of Evidence2Technical EfficacyStage 2

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The atypical protein kinase RIOK3 contributes to the phenotypic modulation of vascular smooth muscle cells in intracranial aneurysms

Wei,

Zhang,

Xie

et al. 2024

Mol. Cell. Toxicol.

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Imaging markers of intracranial aneurysm development: A systematic review

Cited by 10 publications

References 50 publications

Imaging of the Anterior Communicating Artery: Normal and Abnormal Findings Related to Aneurysm

Imaging of the Anterior Communicating Artery: Normal and Abnormal Findings Related to Aneurysm

Hemodynamic Parameters in the Parent Arteries of Unruptured Intracranial Aneurysms Depend on Aneurysm Size and Are Different Compared to Contralateral Arteries: A 7 Tesla 4D Flow MRI Study

The atypical protein kinase RIOK3 contributes to the phenotypic modulation of vascular smooth muscle cells in intracranial aneurysms

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