Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye

Maupu, Clémence; Lebas, Héloïse; Boulaftali, Yacine

doi:10.3389/fcvm.2022.793072

Cited by 21 publications

(17 citation statements)

References 102 publications

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“…Actually, endogenous IA models mainly use small animals like rats (Fig. 2 D) making IA imaging more difficult due to the very small size of the induced lesions [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

“…Indeed, spatial resolution of the commonly available modalities to image IAs in animals is limited: DSA (< 0.5 mm [ 207 ]), CT (≈1 mm [ 7 ]), and MRA (1–2 mm [ 208 ]). Yet, in vivo imaging has greatly improved, and several high-resolution imaging modalities exist: 3D-DSA (0.15 mm [ 209 ]), high-resolution CTA (0.25 mm [ 8 ]), high-resolution MRA (50 µm [ 156 ]), as well as HF-OCT (10 µm [ 182 ]). Small rodents like rats and mice, which are mostly used for endogenous IA models, are often exposed to MRA and hemodynamic imaging and less frequently to conventional catheter angiography, which is mainly used in bigger animal models (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, these techniques are not appropriate for endogenously induced IAs in small animals which require high-resolution imaging. DSA is the gold standard technique as it displays a high resolution that can further be increased with 3D-DSA [ 8 ]. The resolution of CTA seems to be increased when combined with a flat detector [ 102 ].…”

Section: Discussionmentioning

confidence: 99%

“…In vivo imaging techniques are of paramount importance in the management of IAs. Indeed, high-resolution imaging is needed to assess precisely size and morphology of the IA (presence of blebs, lobules, rough aspect), which is necessary to evaluate the risk of rupture of an IA at its discovery and during follow-up imaging [ 7 , 8 ]. IAs of large diameter or displaying irregular vessel walls have been linked to an increased risk of rupture.…”

Section: Introductionmentioning

confidence: 99%

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Imaging of intracranial aneurysms in animals: a systematic review of modalities

et al. 2023

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Intracranial aneurysm (IA) animal models are paramount to study IA pathophysiology and to test new endovascular treatments. A number of in vivo imaging modalities are available to characterize IAs at different stages of development in these animal models. This review describes existing in vivo imaging techniques used so far to visualize IAs in animal models. We systematically searched for studies containing in vivo imaging of induced IAs in animal models in PubMed and SPIE Digital library databases between 1 January 1945 and 13 July 2022. A total of 170 studies were retrieved and reviewed in detail, and information on the IA animal model, the objective of the study, and the imaging modality used was collected. A variety of methods to surgically construct or endogenously induce IAs in animals were identified, and 88% of the reviewed studies used surgical methods. The large majority of IA imaging in animals was performed for 4 reasons: basic research for IA models, testing of new IA treatment modalities, research on IA in vivo imaging of IAs, and research on IA pathophysiology. Six different imaging techniques were identified: conventional catheter angiography, computed tomography angiography, magnetic resonance angiography, hemodynamic imaging, optical coherence tomography, and fluorescence imaging. This review presents and discusses the advantages and disadvantages of all in vivo IA imaging techniques used in animal models to help future IA studies finding the most appropriate IA imaging modality and animal model to answer their research question.

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“…Actually, endogenous IA models mainly use small animals like rats (Fig. 2 D) making IA imaging more difficult due to the very small size of the induced lesions [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Imaging of intracranial aneurysms in animals: a systematic review of modalities

et al. 2023

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“…The input and output data were standardised before training. The spatial resolution of imaging techniques currently used for IAs detection and treatment was considered for evaluating the prediction errors ( Hacein-Bey and Provenzale, 2011 ; Maupu et al., 2022 ): magnetic resonance angiography (MRA) = 0.6 mm–1 mm, computed tomography angiography (CTA) = 0.4 mm–0.7 mm, digital subtraction angiography (DSA) = 0.2 mm, 3D rotational angiography (3DRA) = 0.15 mm.…”

Section: Resultsmentioning

confidence: 99%

Machine learning and reduced order modelling for the simulation of braided stent deployment

et al. 2023

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Endoluminal reconstruction using flow diverters represents a novel paradigm for the minimally invasive treatment of intracranial aneurysms. The configuration assumed by these very dense braided stents once deployed within the parent vessel is not easily predictable and medical volumetric images alone may be insufficient to plan the treatment satisfactorily. Therefore, here we propose a fast and accurate machine learning and reduced order modelling framework, based on finite element simulations, to assist practitioners in the planning and interventional stages. It consists of a first classification step to determine a priori whether a simulation will be successful (good conformity between stent and vessel) or not from a clinical perspective, followed by a regression step that provides an approximated solution of the deployed stent configuration. The latter is achieved using a non-intrusive reduced order modelling scheme that combines the proper orthogonal decomposition algorithm and Gaussian process regression. The workflow was validated on an idealized intracranial artery with a saccular aneurysm and the effect of six geometrical and surgical parameters on the outcome of stent deployment was studied. We trained six machine learning models on a dataset of varying size and obtained classifiers with up to 95% accuracy in predicting the deployment outcome. The support vector machine model outperformed the others when considering a small dataset of 50 training cases, with an accuracy of 93% and a specificity of 97%. On the other hand, real-time predictions of the stent deployed configuration were achieved with an average validation error between predicted and high-fidelity results never greater than the spatial resolution of 3D rotational angiography, the imaging technique with the best spatial resolution (0.15 mm). Such accurate predictions can be reached even with a small database of 47 simulations: by increasing the training simulations to 147, the average prediction error is reduced to 0.07 mm. These results are promising as they demonstrate the ability of these techniques to achieve simulations within a few milliseconds while retaining the mechanical realism and predictability of the stent deployed configuration.

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The relationship between symptomatic status and aneurysm wall enhancement characteristics of single unruptured intracranial aneurysm

Chen,

Zhang,

et al. 2024

Radiologie

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Objective We aimed to analyze the aneurysm wall enhancement (AWE) characteristics of a single unruptured intracranial aneurysm (UIA) and observe the relationship between the symptoms of a single UIA and the aneurysm wall. Methods In our hospital, 85 patients diagnosed with a single UIA using computed tomography angiography (CTA) were retrospectively analyzed. The patients were divided into symptomatic and asymptomatic groups, including 46 asymptomatic and 39 symptomatic aneurysms. High-resolution magnetic resonance imaging of the vascular wall (HR-MR-VWI) was utilized to ascertain the presence, degree, and extent of AWE and thick-wall enhancement. In addition to AWE characteristics, morphological parameters of aneurysms, such as maximal size, shape, height, neck width, aspect ratio (AR), and size ratio (SR), were scanned using CTA. The differences in the parameters of a single UIA between the two groups were compared. An investigation explored the correlation between the symptom status of a single UIA and AWE. Results We observed a correlation between symptom status and maximal size, height, and neck width for a single UIA, the presence or absence of AWE, and the levels and boundaries of AWE and thick-wall reinforcement. This study found that the AWE range was independently correlated with symptom status in the multivariate regression analysis. Conclusion A larger AWE range was an independent risk factor for the onset of symptoms in a single UIA.

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Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye

Cited by 21 publications

References 102 publications

Imaging of intracranial aneurysms in animals: a systematic review of modalities

Imaging of intracranial aneurysms in animals: a systematic review of modalities

Machine learning and reduced order modelling for the simulation of braided stent deployment

The relationship between symptomatic status and aneurysm wall enhancement characteristics of single unruptured intracranial aneurysm

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