Imaging myocardial fiber architecture <i>in vivo</i> with magnetic resonance

Tg, Reese; Rm, Weisskoff; Rn, Smith; Br, Rosen; Re, Dinsmore; Vj, Wedeen

doi:10.1002/mrm.1910340603

Cited by 279 publications

(285 citation statements)

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“…DTI has been successfully applied to the analysis and depiction of neuronal fibers in the living human brain (Mori and van Zijl, 2002). Furthermore, qualitative agreement between main diffusion directions and the fiber orientation in myocardium (Garrido et al, 1994;Reese et al, 1995;Scollan et al, 1998;Schmid et al, 2005) and skeletal muscle (Van Donkelaar et al, 1999;Napadow et al, 2001;Damon et al, 2002;Mori and van Zijl, 2002;Heemskerk et al, 2005) was observed.…”

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confidence: 89%

Three‐dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging

et al. 2005

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The global muscle and collagen fiber orientation in the human uterus has been analyzed hitherto by various standard microscopic techniques. However, no widely accepted model of the fiber architecture of the myometrium could be acquired. The purpose of the present study was to investigate the uterus by magnetic resonance (MR) diffusion tensor imaging (DTI) in a 3D macroscopic approach. Ex vivo MR DTI measurements were performed on five uteri from nonpregnant patients. The main diffusion directions reflecting the orientation of directional structures in the examined tissues were determined from diffusion-weighted spin-echo measurements. A fiber tracking algorithm was used to extrapolate the fiber architecture. The method was validated against histological slides and indirectly through the analysis of leiomyomas, which exhibit less anisotropy than normal myometrium. Significant anisotropy was found in most regions of all examined nonpregnant human uteri. But only two systems of fibers were found running circularly along the intramural part of the uterine tubes. They merged caudally and built a close fitting envelope of circular layers around the uterine cavity. On the cervix, circular fibers were observed in the outer part as well as mostly longitudinal fibers in the inner part. These results confirm the existence of directional structures in the complex fiber architecture of the human uterus. They also indicate that MR DTI is a beneficial and complementary tool to standard microscopic techniques to determine the intrinsic fiber architecture in human organs.

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confidence: 89%

Three‐dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging

et al. 2005

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“…These include: (1) the use of the octahedral icon for each pixel (Reese et al, 1995); (2) color maps, where different intensities of the three colors indicate the size and the ADC in each of the three Cartesian directions (Makris et al, 1997); (3) rendered ellipsoids to visualize diffusion data in a slice, and (Pierpaoli et al, 1996); and (4) the use of lines to represent the in-plane component of the principal diffusion direction, along with a color-coded out-of-plane component ) (see Fig. 4).…”

Section: Quantitative Representation Of Diffusion Tensormentioning

confidence: 99%

A review of diffusion tensor imaging studies in schizophrenia

Kubicki

McCarley

Westin

et al. 2007

Journal of Psychiatric Research

691

532

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Both post-mortem and neuroimaging studies have contributed significantly to what we know about the brain and schizophrenia. MRI studies of volumetric reduction in several brain regions in schizophrenia have confirmed early speculations that the brain is disordered in schizophrenia. There is also a growing body of evidence suggesting that a disturbance in connectivity between different brain regions, rather than abnormalities within the separate regions themselves, are responsible for the clinical symptoms and cognitive dysfunctions observed in this disorder. Thus an interest in white matter fiber tracts, subserving anatomical connections between distant, as well as proximal, brain regions, is emerging. This interest coincides with the recent advent of diffusion tensor imaging (DTI), which makes it possible to evaluate the organization and coherence of white matter fiber tracts. This is an important advance as conventional MRI techniques are insensitive to fiber tract direction and organization, and have not consistently demonstrated white matter abnormalities. DTI may, therefore, provide important new information about neural circuitry, and it is increasingly being used in neuroimaging studies of psychopathological disorders. Of note, in the past five years 18 DTI studies in schizophrenia have been published, most describing white matter abnormalities. Questions still remain, however, regarding what we are measuring that is abnormal in this disease, and how measures obtained using one method correspond to those obtained using other methods? Below we review the basic principles involved in MR-DTI, followed by a review of the different methods used to evaluate diffusion. Finally, we review MR-DTI findings in schizophrenia.

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“…Moreover, we have not taken into account the variance of both fiber and sheet direction at each site. At the present time, it is not possible to determine fiber and sheet anatomy in the beating heart, although diffusion MRI shows considerable promise (29). Thus measurements must be done in different hearts fixed at different filling pressures, a task that has not been undertaken in larger hearts.…”

Section: Limitationsmentioning

confidence: 99%

Contribution of laminar myofiber architecture to load-dependent changes in mechanics of LV myocardium

Takayama

Costa

Covell

2002

American Journal of Physiology-Heart and Circulatory Physiology

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Takayama, Yasuo, Kevin D. Costa, and James W. Covell. Contribution of laminar myofiber architecture to load-dependent changes in mechanics of LV myocardium. Am J Physiol Heart Circ Physiol 282: H1510-H1520, 2002; 10.1152/ajpheart.00261.2001.-The ventricular myocardium consists of a syncytium of myocytes organized into branching, transmurally oriented laminar sheets approximately four cells thick. When systolic deformation is expressed in an axis system determined by the anatomy of the laminar architecture, laminar sheets of myocytes shear and laterally extend in an approximately radial direction. These deformations account for ϳ90% of normal systolic wall thickening in the left ventricular free wall. In the present study, we investigated whether the changes in systolic and diastolic function of the sheets were sensitive to alterations in systolic and diastolic load. Our results indicate that there is substantial reorientation of the laminar architecture during systole and diastole. Moreover, this reorientation is both site and load dependent. Thus as end-diastolic pressure is increased and the left ventricular wall thins, sheets shorten and rotate away from the radial direction due to transverse shearing, opposite of what occurs in systole. Both mechanisms of thickening contribute substantially to normal left ventricular wall function. Whereas the relative contributions of shear and extension are comparable at the base, sheet shear is the predominant factor at the apex. The magnitude of shortening/extension and shear increases with preload and decreases with afterload. These findings underscore the essential contribution of the laminar myocardial architecture for normal ventricular function throughout the cardiac cycle. myocardium; wall thickening; systole; diastole THE VENTRICULAR MYOCARDIUM consists of a syncytium of myocytes organized into branching transmurally oriented laminar sheets approximately four cells thick (14). Recent evidence indicates that this laminar structure contributes importantly to systolic function. When systolic deformation is expressed in an axis system determined by the anatomy of the laminar architecture, laminar sheets of myocytes shear and laterally extend in an approximately radial direction. These deformations account for ϳ90% of normal systolic wall thickening in the left ventricular (LV) free wall. In a recent study (5) from this laboratory, we found regional variations in the relative contribution of sheet extension and shear to wall thickening. In the free wall of the ventricle, sheet extension accounted for the majority of wall thickening, whereas in the septum, sheet shear was the predominant factor. Systolic wall thickening is a commonly employed index of regional myocardial performance (8) in both clinical and experimental studies. However, wall thickening varies both transmurally and regionally (7). These variations were reported in clinical studies (3) using magnetic resonance imaging (MRI). Moreover, Villarreal et al. (36) have shown regional variations in the sensit...

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Imaging myocardial fiber architecture in vivo with magnetic resonance

Cited by 279 publications

References 20 publications

Three‐dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging

Three‐dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging

A review of diffusion tensor imaging studies in schizophrenia

Contribution of laminar myofiber architecture to load-dependent changes in mechanics of LV myocardium

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