Imaging of Abdominal Neuroblastoma in Children

Hugosson, Claes; Nyman, Rickard; Jorulf, H; McDonald, Peter J.; Rifai, Ayman; Kofide, A.; Jacobsson, Bo

doi:10.3109/02841859909175580

Cited by 44 publications

(37 citation statements)

References 26 publications

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“…MRI has advantages in evaluating the extent of a primary tumor and a possible vessel encasement and in determining operability [3,4,[24][25][26]. In our study, the sensitivity of MRI (86%) was markedly higher than its specificity (77%).…”

Section: Discussioncontrasting

confidence: 56%

“…In the literature, comparative studies about the diagnostic value of MIBG scintigraphy and MRI in staging neuroblastoma in pediatric patients have been published [4,14]. The basis of any staging procedure is the detection of single tumor lesions.…”

Section: Pfluger Et Almentioning

confidence: 99%

“…It shows an infiltrative growth pattern with early metastatic disease, with metastases being revealed in one half to two thirds of the patients at presentation [4]. Imaging of neuroblastoma consists of sonography, CT, MRI, and radionuclide examinations such as scintigraphic bone scanning and metaiodobenzylguanidine (MIBG) scintigraphy [4,5]. The therapeutic spectrum is supportive care with no treatment (stage IVS), definitive excision if possible, or chemotherapy before and after surgery partially combined with total-body irradiation, and followed by autologous bone marrow transplantation [6].…”

mentioning

confidence: 98%

“…The tumor is most frequently situated in the adrenal gland or anywhere else along the sympathetic nervous system chain [1]. It shows an infiltrative growth pattern with early metastatic disease, with metastases being revealed in one half to two thirds of the patients at presentation [4]. Imaging of neuroblastoma consists of sonography, CT, MRI, and radionuclide examinations such as scintigraphic bone scanning and metaiodobenzylguanidine (MIBG) scintigraphy [4,5].…”

mentioning

confidence: 99%

See 3 more Smart Citations

Integrated Imaging Using MRI and ¹²³| Metaiodobenzylguanidine Scintigraphy to Improve Sensitivity and Specificity in the Diagnosis of Pediatric Neuroblastoma

Pfluger

Schmied

Porn

et al. 2003

American Journal of Roentgenology

106

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Section: Discussioncontrasting

confidence: 56%

Section: Pfluger Et Almentioning

confidence: 99%

mentioning

confidence: 98%

mentioning

confidence: 99%

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Integrated Imaging Using MRI and ¹²³| Metaiodobenzylguanidine Scintigraphy to Improve Sensitivity and Specificity in the Diagnosis of Pediatric Neuroblastoma

Pfluger

Schmied

Porn

et al. 2003

American Journal of Roentgenology

106

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“…However, there were cases where CT/MR imaging identified a tumour that was not detected by other methods. Previous work has shown that CT and MR imaging are superior to ultrasound in detecting abdominal neuroblastoma; both CT and MR assessed tumour size and location equally well 11. For thoracic tumours, MR imaging appears to be the single most useful test for detecting nodal, intraspinal and chest wall involvement 12.…”

Section: Discussionmentioning

confidence: 99%

Investigating neuroblastoma in childhood opsoclonus-myoclonus syndrome

et al. 2011

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123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma

Bleeker¹,

Tytgat

Adam

et al. 2015

Cochrane Database of Systematic Reviews

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Background Neuroblastoma is an embryonic tumour of childhood that originates in the neural crest. It is the second most common extracranial malignant solid tumour of childhood. Neuroblastoma cells have the unique capacity to accumulate Iodine‐123‐metaiodobenzylguanidine (¹²³I‐MIBG), which can be used for imaging the tumour. Moreover, ¹²³I‐MIBG scintigraphy is not only important for the diagnosis of neuroblastoma, but also for staging and localization of skeletal lesions. If these are present, MIBG follow‐up scans are used to assess the patient's response to therapy. However, the sensitivity and specificity of ¹²³I‐MIBG scintigraphy to detect neuroblastoma varies according to the literature. Prognosis, treatment and response to therapy of patients with neuroblastoma are currently based on extension scoring of ¹²³I‐MIBG scans. Due to its clinical use and importance, it is necessary to determine the exact diagnostic accuracy of ¹²³I‐MIBG scintigraphy. In case the tumour is not MIBG avid, fluorine‐18‐fluorodeoxy‐glucose ( 18 F‐FDG) positron emission tomography (PET) is often used and the diagnostic accuracy of this test should also be assessed. Objectives Primary objectives: 1.1 To determine the diagnostic accuracy of ¹²³I‐MIBG (single photon emission computed tomography (SPECT), with or without computed tomography (CT)) scintigraphy for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old. 1.2 To determine the diagnostic accuracy of negative ¹²³I‐MIBG scintigraphy in combination with 18 F‐FDG‐PET(‐CT) imaging for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old, i.e. an add‐on test. Secondary objectives: 2.1 To determine the diagnostic accuracy of 18 F‐FDG‐PET(‐CT) imaging for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old. 2.2 To compare the diagnostic accuracy of ¹²³I‐MIBG (SPECT‐CT) and 18 F‐FDG‐PET(‐CT) imaging for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old. This was performed within and between included studies. ¹²³I‐MIBG (SPECT‐CT) scintigraphy was the comparator test in this case. Search methods We searched the databases of MEDLINE/PubMed (1945 to 11 September 2012) and EMBASE/Ovid (1980 to 11 September 2012) for potentially relevant articles. Also we checked the reference lists of relevant articles and review articles, scanned conference proceedings and searched for unpublished studies by contacting researchers involved in this area. Selection criteria We included studies of a cross‐sectional design or cases series of prove...

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Imaging of Abdominal Neuroblastoma in Children

Abstract: Imaging may be a valuable basis for clinical assessment and pretreatment staging of abdominal neuroblastoma.

Cited by 44 publications

References 26 publications

Integrated Imaging Using MRI and ¹²³| Metaiodobenzylguanidine Scintigraphy to Improve Sensitivity and Specificity in the Diagnosis of Pediatric Neuroblastoma

Integrated Imaging Using MRI and ¹²³| Metaiodobenzylguanidine Scintigraphy to Improve Sensitivity and Specificity in the Diagnosis of Pediatric Neuroblastoma

Investigating neuroblastoma in childhood opsoclonus-myoclonus syndrome

123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma

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Imaging of Abdominal Neuroblastoma in Children

Abstract: Imaging may be a valuable basis for clinical assessment and pretreatment staging of abdominal neuroblastoma.

Cited by 44 publications

References 26 publications

Integrated Imaging Using MRI and 123| Metaiodobenzylguanidine Scintigraphy to Improve Sensitivity and Specificity in the Diagnosis of Pediatric Neuroblastoma

Integrated Imaging Using MRI and 123| Metaiodobenzylguanidine Scintigraphy to Improve Sensitivity and Specificity in the Diagnosis of Pediatric Neuroblastoma

Investigating neuroblastoma in childhood opsoclonus-myoclonus syndrome

123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma

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Integrated Imaging Using MRI and ¹²³| Metaiodobenzylguanidine Scintigraphy to Improve Sensitivity and Specificity in the Diagnosis of Pediatric Neuroblastoma

Integrated Imaging Using MRI and ¹²³| Metaiodobenzylguanidine Scintigraphy to Improve Sensitivity and Specificity in the Diagnosis of Pediatric Neuroblastoma