Imaging of Acute Pancreatitis

Thoeni, Ruedi F.

doi:10.1016/j.rcl.2015.06.006

Cited by 40 publications

(30 citation statements)

References 53 publications

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“…SAP is due to trypsinogen activation, which leads to inflammatory response including autodigestion, edema, hemorrhage, and even necrosis of the pancreas [1-3]. The pathogenic mechanism of SAP has not been fully investigated whatever the cause.…”

Section: Introductionmentioning

confidence: 99%

Dachengqi Decoction Attenuates Intestinal Vascular Endothelial Injury in Severe Acute Pancreatitis in Vitro and in Vivo

Pan

Chen

et al. 2017

Cell Physiol Biochem

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Background/Aims: Dachengqi decoction (DCQD) is a well-known traditional Chinese herbal drug with strong anti-inflammatory effects. Angiopoietin-1 (Ang-1) plays a vital role in maintaining the stability and integrity of the vascular wall and prevents vascular leakage due to inflammatory mediators. Our previous work found that DCQD protects against pancreatic injury in rats with severe acute pancreatitis (SAP). This study aims to investigate the effects of DCQD on intestinal endothelial damage in both damaged human umbilical vein endothelial cells (HUVECs) and SAP rats. Methods: HUVECs were randomly divided into four groups: control group, TNF-α group, TNF-α plus Ang-1 group (Ang-1 group), and TNF-α plus DCQD group (DCQD group). Cells were incubated for 6 h, 12 h, and 24 h, before collection. The treatment concentration of DCQD was decided based on a Cell Counting Kit-8 (CCK-8) assay. The monolayer permeability of the HUVECs was assessed by measuring the transendothelial electrical resistance (TEER). Apoptosis was analyzed by flow cytometry. mRNA and protein expression of aquaporin 1 (AQP-1), matrix metalloproteinase 9 (MMP9), and junctional adhesion molecule-C (JAM-C) was evaluated by RT-PCR, immunocytofluorescence, and western blot. Forty male Sprague-Dawley rats were randomized into a control group, SAP group, SAP plus Ang-1 group (Ang-1 group), and SAP plus DCQD group (DCQD group). SAP was induced by intraperitoneal injection of cerulein and lipopolysaccharide (LPS), while the control group received 0.9% saline solution. Evans blue was injected through the penile vein and the rats were then sacrificed 12 h after modeling. Levels of serum amylase, TNF-α, IL-1β, IL-2, and IL-6 were determined by using ELISA. Intestinal tissue was analysed by histology, and capillary permeability in the tissues was evaluated by Evans blue extravasation assay. Protein and mRNA expression of AQP-1, MMP9, and JAM-C were assessed by immunohistofluorescence, western blot, and RT-PCR. Results: DCQD reduced the permeability of HUVEC induced by TNF-α in vitro. Furthermore, DCQD altered the mRNA and protein levels of JAM-C, MMP9, and AQP-1 in HUVECs after TNF-α induction. SAP intestinal injury induced by cerulein combined with lipopolysaccharides was concomitant with increased expression of JAM-C and MMP9, and reduced expression of AQP-1 in intestinal tissue. Pretreatment with DCQD attenuated SAP intestinal injury and lowered the levels of serum amylase, TNF–α, IL-1β, IL-2, and IL-6 effectively. Our study demonstrated that DCQD decreased the expression of JAM-C and MMP9 and increased the expression of AQP-1 both in vitro and in vivo. Conclusion: DCQD can reduce capillary endothelial damage in acute pancreatitis-associated intestinal injury and the mechanism may be associated with the regulation of endothelial barrier function-associated proteins AQP-1, MMP9, and JAM-C.

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Section: Introductionmentioning

confidence: 99%

Dachengqi Decoction Attenuates Intestinal Vascular Endothelial Injury in Severe Acute Pancreatitis in Vitro and in Vivo

Pan

Chen

et al. 2017

Cell Physiol Biochem

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“…CT is at present the best imaging technique for the initial assessment and follow-up of patients with acute pancreatitis ( Table 1) (12,14,15,104,105). Advantageous features of currently available multi-slice CT scanners are the high speed of acquisition with narrow collimation, high image resolution, possibility of multi-planar imaging and reformats using volume data.…”

Section: Role Of Ct In Acute Pancreatitismentioning

confidence: 99%

“…Serial CT enables following the evolution of pancreatic collections and will delineate the extent of extrapancreatic inflammatory changes that will serve as a roadmap for interventional procedures like endoscopic, transabdominal, or minimal invasive surgical approaches. Imaging protocols vary in practice worldwide, but the common opinion is to obtain thin section images during the pancreatic (delay of 40-50 seconds) or portal venous phase (delay 60-70 seconds) (15,92,104,105,120). The use of intravenous contrast material is essential for detecting parenchymal necrosis and vascular complications.…”

Section: Role Of Ct In Acute Pancreatitismentioning

confidence: 99%

“…Thickening of the small bowel mesentery, renal fascia, and lateroconal fascia is common. More severe forms of interstitial pancreatitis can result in moderate amounts of peripancreatic fluid (15,104,105). Morbidity from interstitial disease ranges about 10% with mortality less than 3%, primarily due to co-morbid disease (95).…”

Section: Imaging and Severitymentioning

confidence: 99%

“…Imaging modalities available for assessment of acute pancreatitis include conventional radiography, abdominal ultrasound (US), multidetector computed tomography (CT), and magnetic resonance imaging (MRI). Of these, CT has become the standard of choice and worldwide the most commonly used imaging modality for the initial evaluation of acute pancreatitis and its sequelae (12,14,15,104,105). This chapter reviews the role of imaging in the evaluation of patients with acute pancreatitis.…”

Section: Introductionmentioning

confidence: 99%

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Imaging Assessment of Etiology and Severity of Acute Pancreatitis

Bollen¹

The Pancreapedia: Exocrine Pancreas Knowledge Base

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Acute pancreatitis is a polymorphic disease with dynamic imaging characteristics and a multitude of possible complications established on crosssectional imaging. Effective utilization of imaging in patients with acute pancreatitis requires a profound knowledge of the natural course of disease and familiarity with the subtypes and complications of acute pancreatitis. Imaging, primarily computed tomography (CT), in acute pancreatitis has various aims. CT can confirm the diagnosis or provide an alternative diagnosis, identify the etiology of pancreatitis, detect local pancreatic and extrapancreatic complications, offer prognostic information, and guide therapeutic interventions. Conventional radiography, ultrasound (US), endoscopic retrograde cholangiopancreatography (ERCP), and magnetic resonance imaging (MRI) have important complementary roles in the assessment and management of patients with acute pancreatitis. This chapter will discuss the role of imaging in the assessment of etiology of acute pancreatitis. Also, imaging characteristics of those with predicted severe disease and those with pancreatic and extrapancreatic complications directly influencing individual patient management will be addressed.

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CG‐Net: A novel CNN framework for gastrointestinal tract diseases classification

Siddiqui,

Akram,

Ashraf

et al. 2024

Int J Imaging Syst Tech

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The classification of medical images has had a significant influence on the diagnostic techniques and therapeutic interventions. Conventional disease diagnosis procedures require a substantial amount of time and effort to accurately diagnose. Based on global statistics, gastrointestinal cancer has been recognized as a major contributor to cancer‐related deaths. The complexities involved in resolving gastrointestinal tract (GIT) ailments arise from the need for elaborate methods to precisely identify the exact location of the problem. Therefore, doctors frequently use wireless capsule endoscopy to diagnose and treat GIT problems. This research aims to develop a robust framework using deep learning techniques to effectively classify GIT diseases for therapeutic purposes. A CNN based framework, in conjunction with the feature selection method, has been proposed to improve the classification rate. The proposed framework has been evaluated using various performance measures, including accuracy, recall, precision, F1 measure, mean absolute error, and mean squared error.

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Imaging of Acute Pancreatitis

Cited by 40 publications

References 53 publications

Dachengqi Decoction Attenuates Intestinal Vascular Endothelial Injury in Severe Acute Pancreatitis in Vitro and in Vivo

Dachengqi Decoction Attenuates Intestinal Vascular Endothelial Injury in Severe Acute Pancreatitis in Vitro and in Vivo

Imaging Assessment of Etiology and Severity of Acute Pancreatitis

CG‐Net: A novel CNN framework for gastrointestinal tract diseases classification

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